| UNIVERSITY OF SOUTH CAROLINA SCHOOL OF | Columbia | B54Z Education | $40.1M | 20 |
| WE ARE SHARING HOPE SC | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $39.7M | 8 |
| CONTAINER ROYALTY SUPPLEMENTAL | Charleston | Z99 Unknown | $39.2M | 3 |
| DARLA MOORE AND RICHARD RAINWATER | Lake City | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $38.6M | 1 |
| CAROLINA HEALTH CENTERS INC | Greenwood | E32Z Health Care | $38.3M | 11 |
| SOUTH CAROLINA LEARNS | Greenville | B99 Education | $37.4M | 2 |
| HAMPTON REGIONAL MEDICAL CENTER | Varnville | E220 Health Care | $36.9M | 6 |
| LIMESTONE CHARTER ASSOCIATION | Columbia | — | $36.8M | 5 |
| LEXMED INC | Lexington | E91 Health Care | $36.5M | 10 |
| RADIO TRAINING NETWORK INC | Greenville | X800 Religion-Related | $36.3M | 11 |
| Voorhees College | Denmark | B42Z Education | $36.2M | 5 |
| WEST CAROLINA RURAL TELEPHONE | Abbeville | — | $36.1M | 15 |
| Columbia College | Columbia | B420 Education | $35.8M | 11 |
| SUNBELT HUMAN ADVANCEMENT RESOURCES INC | Greenville | B210 Education | $35.7M | 4 |
| RICHLAND COUNTY PUBLIC LIBRARY | Columbia | B700 Education | $34.9M | 7 |
| CONVERSE UNIVERSITY | Spartanburg | B430 Education | $34.7M | 10 |
| CHRIST CHURCH EPISCOPAL SCHOOL | Greenville | B20 Education | $34.6M | 9 |
| LITTLE RIVER ELECTRIC | Abbeville | — | $34.2M | 16 |
| THE CHARLES LEA CENTER INC | Spartanburg | E50Z Health Care | $33.6M | 5 |
| THE CITADEL FOUNDATION | Charleston | B110 Education | $33.6M | 7 |
| CLC ADMINISTRATIVE SERVICES INC | Spartanburg | — | $33.4M | 0 |
| TANDEM HEALTH SC | Sumter | E20 Health Care | $33.2M | 9 |
| GLEAMNS HUMAN RESOURCES COMMISSION | Greenwood | B22Z Education | $32.7M | 3 |
| CHARLESTON AREA CONVENTION & VISITORS | Charleston | S20 Community Improvement & Capacity Building | $32.3M | 7 |
| YMCA OF GREENVILLE | Greenville | P270 Human Services | $32.3M | 8 |
| St Francis Physician Services Inc | Greenville | E32 Health Care | $32.2M | 18 |
| CENTRAL CAROLINA COMMUNITY | Columbia | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $31.8M | 4 |
| GREENWOOD GENETIC CENTER INC | Greenwood | H200 Medical Research | $31.7M | 12 |
| SECURING ASSETS FOR EDUCATION | Moncks Corner | B11 Education | $31.7M | 0 |
| SOUTH CAROLINA VIRTUAL CHARTER | West Columbia | B99 Education | $30.8M | 10 |
| BEAUFORT-JASPER-HAMPTON COMPREHENSIVE | Okatie | E30Z Health Care | $30.7M | 9 |
| Wateree Community Actions Inc | Columbia | P50 Human Services | $30.4M | 0 |
| FORT MILL PUBLIC FACILITIES CORPORATION | Fort Mill | W20 Public & Societal Benefit | $30.4M | 0 |
| NEW HORIZON FAMILY HEALTH | Greenville | E30Z Health Care | $30.2M | 9 |
| SCBMA | Columbia | P750 Human Services | $29.9M | 7 |
| COMMUNITY FOUNDATION OF | Greenville | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $29.8M | 2 |
| Southern Wesleyan University | Central | B42Z Education | $29.8M | 6 |
| COKER UNIVERSITY | Hartsville | B420 Education | $29.4M | 7 |
| ROLLING GREEN VILLAGE | Greenville | — | $29.1M | 6 |
| SANDHILLS MEDICAL FOUNDATION INC | McBee | E39Z Health Care | $28.9M | 11 |
| COASTAL ELECTRIC COOPERATIVE INC | Walterboro | — | $28.6M | 16 |
| EDGEFIELD COUNTY PUBLIC FACILITIES | Edgefield | P20 Human Services | $28.5M | 0 |
| GREENVILLE RENEWABLE ENERGY EDUCATION | Greenville | B20 Education | $28.5M | 2 |
| SOUTH CAROLINA MEDICAL ASSOCIATION | Columbia | Y43 Mutual & Membership Benefit | $28.3M | 4 |
| SOUTH CAROLINA PROPERTY AND | Columbia | — | $28.1M | 0 |
| Affinity Health Center | Rock Hill | G81 Diseases, Disorders & Medical Disciplines | $27.7M | 7 |
| LOW COUNTRY HEALTH CARE SYSTEM INC | Fairfax | E32 Health Care | $27.7M | 8 |
| ASHLEY HALL FOUNDATION | Charleston | B200 Education | $27.1M | 8 |
| SOUTH CAROLINA YOUTH ADVOCATE PROGRAM | Columbia | P320 Human Services | $26.9M | 8 |
| JAMES ISLAND CHARTER HIGH SCHOOL | Charleston | B29 Education | $26.7M | 6 |
