| MEMORIAL HEALTH SERVICES | Fountain Valley | E122 Health Care | $422.1M | 28 |
| SAG-AFTRA HEALTH PLAN | Burbank | — | $420.1M | 11 |
| NORTH BAY DEVELOPMENTAL DISABILITIES | Napa | P820 Human Services | $414.8M | 7 |
| CITY OF HOPE | Duarte | E050 Health Care | $413.3M | 16 |
| ZOOLOGICAL SOCIETY OF SAN DIEGO | San Diego | D500 Animal-Related | $411M | 12 |
| STAR ONE CREDIT UNION | Sunnyvale | — | $409.8M | 21 |
| The David and Lucile Packard Foundation | Los Altos | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $407.6M | 5 |
| REDLANDS COMMUNITY HOSPITAL | Redlands | E220 Health Care | $407.1M | 7 |
| USC CARE MEDICAL GROUP INC | Los Angeles | E300 Health Care | $403.7M | 35 |
| CATALIGHT FOUNDATION | Walnut Creek | E50Z Health Care | $400.8M | 17 |
| NATIONAL UNIVERSITY | San Diego | B430 Education | $400.2M | 14 |
| OROVILLE HOSPITAL | Oroville | E220 Health Care | $397.7M | 14 |
| CALSTART INC | Pasadena | Z99Z Unknown | $396.8M | 9 |
| PIH Health Good Samaritan Hospital | Los Angeles | E220 Health Care | $391.2M | 13 |
| SANSUM CLINIC | Sacramento | E320 Health Care | $387.2M | 19 |
| Front Porch Communities and Services | Glendale | L22 Housing & Shelter | $380.2M | 16 |
| TEAMSTERS BENEFIT TRUST | Fremont | — | $379.8M | 0 |
| MARTIN LUTHER KING JR-LOS ANGELES | Los Angeles | E22 Health Care | $377.8M | 21 |
| VALLEY MOUNTAIN REGIONAL CENTER INC | Stockton | P82Z Human Services | $373M | 7 |
| THE J PAUL GETTY TRUST | Los Angeles | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $370.2M | 11 |
| FAMILY HEALTH CENTERS OF SAN DIEGO INC | San Diego | E30Z Health Care | $369.8M | 30 |
| COMMONSPIRIT HEALTH OPERATING INVESTMENT | San Francisco | X22 Religion-Related | $367.7M | 2 |
| CRYSTAL STAIRS INC | Los Angeles | A25 Arts, Culture & Humanities | $365.3M | 8 |
| LOMA LINDA UNIVERSITY | Loma Linda | B430 Education | $365.3M | 29 |
| CCPOA BENEFIT TRUST FUND | Sacramento | — | $359.4M | 6 |
| THE ERIC AND WENDY SCHMIDT FUND FOR | Palo Alto | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $357.9M | 3 |
| LABORERS HEALTH & WELFARE TRUST FOR | Covina | — | $355M | 9 |
| CLIMATEWORKS FOUNDATION | San Francisco | U12 Science & Technology | $350.6M | 15 |
| TIDES FOUNDATION | San Francisco | T300 Philanthropy, Voluntarism & Grantmaking Foundations | $350.1M | 4 |
| Harbor Developmental Disabilities | Torrance | P820 Human Services | $349.7M | 7 |
| PIH Health Physicians | Whittier | E320 Health Care | $348.8M | 17 |
| UNIVERSITY HEALTHCARE ALLIANCE | Newark | — | $348.1M | 21 |
| Sonora Community Hospital | Sonora | E220 Health Care | $346.7M | 24 |
| MARSHALL MEDICAL CENTER | Placerville | E220 Health Care | $343.6M | 12 |
| Adventist Health Physicians Network | Roseville | E32Z Health Care | $343.3M | 7 |
| LOMA LINDA UNIVERSITY SHARED SERVICES | San Bernardino | — | $341.2M | 30 |
| CONRAD N HILTON FOUNDATION | Westlake Village | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $340M | 16 |
| COMMUNITY HOSPITALS | Fresno | E210 Health Care | $332.1M | 16 |
| OPERATING ENGINEERS HEALTH AND WELFARE | Alameda | — | $330.6M | 0 |
| NORTH EAST MEDICAL SERVICES | Daly City | E300 Health Care | $327M | 14 |
| HOAG CLINIC | Newport Beach | E30 Health Care | $325.3M | 13 |
| LOS ANGELES COUNTY | Los Angeles | P820 Human Services | $324.2M | 8 |
| WESCOM CENTRAL CREDIT UNION | Pasadena | — | $323.5M | 39 |
| Lodi Memorial Hospital Association Inc | Lodi | E220 Health Care | $322.2M | 0 |
| RETA TRUST | Walnut Creek | — | $318.7M | 2 |
| ASPIRE PUBLIC SCHOOLS | Oakland | B200 Education | $317.7M | 14 |
| YMCA OF SAN DIEGO COUNTY | San Diego | P270 Human Services | $317.3M | 9 |
| LOMA LINDA UNIVERSITY MED CNTR-MURRIETA | San Bernardino | — | $314.7M | 27 |
| COMMUNITY HOSPITAL OF SAN BERNARDINO | San Francisco | E220 Health Care | $306.1M | 15 |
| USC ARCADIA HOSPITAL | Arcadia | E220 Health Care | $306M | 12 |
