| KERN REGIONAL CENTER | Bakersfield | P820 Human Services | $328.8M | 5 |
| WESCOM CENTRAL CREDIT UNION | Pasadena | — | $323.5M | 39 |
| Lodi Memorial Hospital Association Inc | Lodi | E220 Health Care | $322.2M | 21 |
| LOMA LINDA UNIVERSITY MED CNTR-MURRIETA | San Bernardino | — | $319.7M | 29 |
| ASPIRE PUBLIC SCHOOLS | Oakland | B200 Education | $317.7M | 14 |
| YMCA OF SAN DIEGO COUNTY | San Diego | P270 Human Services | $317.3M | 9 |
| OPERATING ENGINEERS HEALTH AND WELFARE FUND | Pasadena | — | $313.2M | 6 |
| SECOND HARVEST OF SILICON VALLEY | San Jose | K310 Food, Agriculture & Nutrition | $311.3M | 7 |
| St Helena Hospital | St Helena | E220 Health Care | $308.8M | 17 |
| FAMILY HEALTHCARE NETWORK | Visalia | E39Z Health Care | $302M | 7 |
| Torrance Health Association | Torrance | E110 Health Care | $301.1M | 15 |
| AAM FOUNDATION | Novato | Q33 International, Foreign Affairs & National Security | $300.8M | 0 |
| FAR NORTHERN COORDINATING COUNCIL ON DEVELOPMENTAL DISABILITIES | Redding | P110 Human Services | $300M | 9 |
| WESTERN STATES CARPENTERS VACATION TRUST | Los Angeles | — | $296.1M | 6 |
| PRIDE Industries | Roseville | P20 Human Services | $295.9M | 12 |
| CALIFORNIA COMMUNITY FOUNDATION | Los Angeles | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $291.6M | 13 |
| Cottage Health | Santa Barbara | X00Z Religion-Related | $290.4M | 16 |
| SEQUOIA CLIMATE FOUNDATION | Irvine | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $289.2M | 3 |
| Los Angeles Police Relief Assoc Inc | Los Angeles | — | $289.2M | 3 |
| UNITED STATES ENERGY FOUNDATION | San Francisco | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $286M | 22 |
| CALIFORNIA INDEPENDENT SYSTEM OPERATOR CORPORATION | Folsom | W99 Public & Societal Benefit | $285.9M | 23 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | Duarte | H30 Medical Research | $285.3M | 21 |
| TRAVIS CREDIT UNION | Vacaville | — | $283.7M | 21 |
| Ukiah Adventist Hospital | Ukiah | — | $282.5M | 21 |
| GOODWILL INDUSTRIES OF SOUTHERN CALIFORNIA | Los Angeles | J320 Employment | $280.7M | 10 |
| ACCESS SERVICES | El Monte | P520 Human Services | $279.2M | 16 |
| GEMOLOGICAL INSTITUTE OF AMERICA INC | Carlsbad | B600 Education | $274.4M | 32 |
| LOS ANGELES REGIONAL FOOD BANK | Los Angeles | — | $273.9M | 19 |
| JEWISH COMMUNITY FOUNDATION OF SAN DIEGO | San Diego | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $273.7M | 7 |
| TEAMSTERS MISCELLANEOUS SECURITY FUND | Pasadena | — | $272.6M | 0 |
| THE CLEAR FUND | Oakland | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $269.5M | 12 |
| ALLIANCE COLLEGE-READY PUBLIC SCHOOLS | Los Angeles | B29 Education | $267.8M | 15 |
| TIDES CENTER | San Francisco | P20 Human Services | $265.4M | 8 |
| Barton Healthcare System | South Lake Tahoe | E220 Health Care | $265.2M | 12 |
| WESTERN UNIVERSITY OF HEALTH SCIENCES | Pomona | — | $265.1M | 17 |
| THE MILKEN INSTITUTE | Santa Monica | — | $264.7M | 8 |
| VALLEY STRONG CU FKA KERN SCHOOLS FEDERAL CREDIT UNION | Bakersfield | W61 Public & Societal Benefit | $263.7M | 47 |
| PIH Health Downey Hospital | Downey | E220 Health Care | $262.2M | 17 |
| SANTE HEALTH FOUNDATION | Fresno | E70 Health Care | $261.7M | 0 |
| EDUCATIONAL MEDIA FOUNDATION | Rocklin | A340 Arts, Culture & Humanities | $261M | 19 |
| ON LOK SENIOR HEALTH SERVICES | San Francisco | E300 Health Care | $259.9M | 10 |
| PACIFIC MARITIME ASSOCIATION | San Francisco | — | $258.3M | 10 |
| Public Health Institute | Oakland | E70Z Health Care | $258.3M | 14 |
| Labor Alliance Managed Trust Fund | Pleasanton | — | $255.2M | 0 |
| Safe Credit Union | Folsom | — | $254.7M | 21 |
| UNITED AGRICULTURAL BENEFIT TRUST | Irvine | — | $254.5M | 1 |
| Children's Hospital Los Angeles Medical Group | Los Angeles | — | $254.3M | 24 |
| MARIN COMMUNITY FOUNDATION | Novato | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $252.4M | 10 |
| SOUTHEASTERN REGIONAL MEDICAL CENTER INC | Duarte | E24 Health Care | $251.3M | 17 |
| Biola University Inc | La Mirada | B430 Education | $250.2M | 20 |
