| ZOOLOGICAL SOCIETY OF PHILADELPHIA | Philadelphia | D500 Animal-Related | $43.7M | 11 |
| NORTHERN TIER INSURANCE CONSORTIUM C/O BLAST IU 17 | Canton | Y43 Mutual & Membership Benefit | $43.6M | 0 |
| CHILDRENS SVC CTR OF WYOM VALLEY INC | Wilkes Barre | F300 Mental Health & Crisis Intervention | $43.5M | 22 |
| CCRES | Downingtown | B19 Education | $43.4M | 7 |
| FOULKEWAYS AT GWYNEDD | Gwynedd | P750 Human Services | $43.3M | 9 |
| LOCAL 8-86 MERCK EMPLOYEES VEBA TRUST | Horsham | — | $42.9M | 0 |
| MAST COMMUNITY CHARTER SCHOOL II | Philadelphia | B29 Education | $42.7M | 6 |
| BAPTIST HOMES SOCIETY | Pittsburgh | E91 Health Care | $42.5M | 6 |
| Great Lakes Physician Practice PC | Pittsburgh | E30 Health Care | $42.3M | 14 |
| HARCUM COLLEGE | Bryn Mawr | B420 Education | $42.3M | 6 |
| INGLIS HOUSE | Philadelphia | P750 Human Services | $42.2M | 10 |
| SHARE FOOD PROGRAM | Philadelphia | K31Z Food, Agriculture & Nutrition | $42M | 5 |
| WHITE HORSE VILLAGE INC | Newtown Square | P750 Human Services | $41.9M | 12 |
| WELLSPAN HEALTH CARE SERVICES | York | E21Z Health Care | $41.9M | 12 |
| GEISINGER COMMUNITY HEALTH SERVICES | Danville | E30 Health Care | $41.8M | 12 |
| TEL HAI RETIREMENT COMMUNITY | Honey Brook | P75 Human Services | $41.8M | 7 |
| TEAMSTERS 261 AND EMPLOYERS WELFARE FUND | New Castle | Y43 Mutual & Membership Benefit | $41.6M | 0 |
| ADVANCED ROBOTICS FOR MANUFACTURING INSTITUTE | Pittsburgh | U05 Science & Technology | $41.6M | 14 |
| PHOEBE SERVICES INC | Allentown | S500 Community Improvement & Capacity Building | $41.3M | 10 |
| ATI-USW VEBA TRUST | Pittsburgh | Y43 Mutual & Membership Benefit | $41.3M | 2 |
| COLCOM FOUNDATION | Pittsburgh | T70J Philanthropy, Voluntarism & Grantmaking Foundations | $41.1M | 14 |
| AMERICAN ELECTRIC POWER SYSTEM RETIREE | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $41.1M | 1 |
| HOPE INTERNATIONAL | Lancaster | Q300 International, Foreign Affairs & National Security | $41M | 4 |
| WAVERLY HEIGHTS | Gladwyne | P750 Human Services | $40.8M | 14 |
| PENNSWOOD VILLAGE | Newtown | P750 Human Services | $40.7M | 8 |
| JEVS CARE AT HOME | Philadelphia | P44 Human Services | $40.5M | 4 |
| REDSTONE PRESBYTERIAN SENIORCARE | Greensburg | P75 Human Services | $40.5M | 11 |
| HAZLETON PROFESSIONAL SERVICES | Allentown | — | $40.4M | 24 |
| LACKAWANNA COLLEGE | Scranton | B41Z Education | $40.3M | 7 |
| CROATIAN FRATERNAL UNION OF AMERICA | Pittsburgh | P84Z Human Services | $40.1M | 11 |
| SHIPLEY SCHOOL | Bryn Mawr | B200 Education | $40.1M | 7 |
| FOUNDATION FOR INDIVIDUAL RIGHTS AND EXPRESSION INC | Philadelphia | R630 Civil Rights, Social Action & Advocacy | $40M | 10 |
| THE HIGHLANDS AT WYOMISSING | Wyomissing | P750 Human Services | $40M | 9 |
| Brian's House Inc | Exton | P70Z Human Services | $39.9M | 9 |
| CENTERVILLE CLINICS INC | Fredericktown | E210 Health Care | $39.9M | 6 |
| ERIE COMMUNITY FOUNDATION | Erie | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $39.8M | 5 |
| WILSON COLLEGE | Chambersburg | B420 Education | $39.7M | 9 |
| NORTHWEST INSTITUTE OF RESEARCH | Erie | — | $39.5M | 2 |
| Electrolux VEBA for Collectively Barg Employees | Pittsburgh | — | $39.5M | 1 |
| VNA OF ST LUKE'S - HOME HEALTHHOSPICE INC | Allentown | P740 Human Services | $39.4M | 7 |
| METRO FAMILY PRACTICE INC | Pittsburgh | E30 Health Care | $39.1M | 8 |
| ST JOSEPHS CENTER | Scranton | P200 Human Services | $39M | 5 |
| Esperanza Academy Charter School | Philadelphia | B29 Education | $39M | 7 |
| LA ROCHE UNIVERSITY | Pittsburgh | B430 Education | $38.8M | 10 |
| PHOEBE HOME INC | Allentown | E910 Health Care | $38.7M | 8 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL WORKERS #98 | Philadelphia | — | $38.6M | 20 |
| TRANSCELERATE BIOPHARMA INC | West Conshohocken | H99 Medical Research | $38.6M | 7 |
| THE UNITED WAY OF SOUTHWESTERN PENNSYLVANIA | Pittsburgh | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $38.5M | 8 |
| MORAVIAN MANORS INC | Lititz | E910 Health Care | $38.5M | 8 |
| ACADEMY IN MANAYUNK | Conshohocken | B24 Education | $38.5M | 10 |
