| INDIANA YOUTH INSTITUTE INC | Indianapolis | P34E Human Services | $26.5M | 5 |
| BARNES & THORNBURG VOLUNTARY EMPLOYEE | Indianapolis | — | $26.5M | 1 |
| CRF AFFORDABLE HOUSING INC | Plainfield | L20 Housing & Shelter | $26.4M | 2 |
| GIRL SCOUTS OF CENTRAL INDIANA INC | Indianapolis | O42 Youth Development | $26.2M | 3 |
| CARDINAL SERVICES INC OF INDIANA | Warsaw | B82 Education | $26.1M | 5 |
| VIA Credit Union | Marion | W61 Public & Societal Benefit | $25.8M | 7 |
| Independent Colleges of Indiana Inc | Indianapolis | B03 Education | $25.8M | 33 |
| PATHFINDER SERVICES INC | Huntington | — | $25.7M | 2 |
| NEW HOPE OF INDIANA INC | Indianapolis | — | $25.6M | 7 |
| Southwestern Behavioral Healthcare Inc | Evansville | F30Z Mental Health & Crisis Intervention | $25.4M | 9 |
| HERRON HIGH SCHOOL INC | Indianapolis | B29 Education | $25.2M | 5 |
| HOLY CROSS COLLEGE INC | Notre Dame | B41Z Education | $25.2M | 7 |
| Regenstrief Institute Inc | Indianapolis | B054 Education | $24.7M | 11 |
| LITTLE STAR CENTER INC | Carmel | B28 Education | $24.7M | 7 |
| WINDROSE HEALTH NETWORK INC | Trafalgar | E32 Health Care | $24.5M | 9 |
| COMMUNITY HARVEST FOOD BANK OF | Fort Wayne | K310 Food, Agriculture & Nutrition | $24.5M | 1 |
| Don Cowden Foundation Inc | Bloomington | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $24.5M | 4 |
| OPPORTUNITY ENTERPRISES INC | Valparaiso | J330 Employment | $24.3M | 7 |
| Neighborhood Health Clinics Inc | Fort Wayne | E30 Health Care | $24.3M | 9 |
| STONE BELT ARC INC | Bloomington | P82Z Human Services | $24.2M | 2 |
| SECOND HARVEST FOOD BANK OF EAST CENTRAL | Muncie | K31Z Food, Agriculture & Nutrition | $24.1M | 1 |
| ADEC INC | Bristol | P80 Human Services | $24M | 5 |
| ESTELLE PEABODY MEMORIAL HOME INC | North Manchester | P750 Human Services | $24M | 8 |
| JAY COUNTY RURAL ELECTRIC | Portland | — | $24M | 15 |
| FAIRBANKS HOSPITAL INC | Indianapolis | F220 Mental Health & Crisis Intervention | $23.8M | 10 |
| THE FRANKLIN UNITED METHODIST HOME INC | Franklin | P750 Human Services | $23.8M | 10 |
| Aspire Indiana Health Inc | Noblesville | E20 Health Care | $23.7M | 17 |
| Oakland City University | Oakland City | B420 Education | $23.7M | 4 |
| Open Door Health Services Inc | Muncie | E30 Health Care | $23.7M | 9 |
| COMMUNITY FOUNDATION OF HANCOCK | Greenfield | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $23.6M | 1 |
| AVONDALE MEADOWS ACADEMY INC | Indianapolis | B29 Education | $23.6M | 1 |
| HERITAGE CHRISTIAN SCHOOLS INC | Indianapolis | B24Z Education | $23.4M | 5 |
| INDIANA SYMPHONY SOCIETY INC | Indianapolis | A690 Arts, Culture & Humanities | $23.4M | 8 |
| HAMILTON COUNTY COMMUNITY FOUNDATION INC | Fishers | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $23.3M | 8 |
| NATIONAL FFA FOUNDATION INC | Indianapolis | O52Z Youth Development | $23.1M | 7 |
| IVY TECH FOUNDATION INC | Indianapolis | B114 Education | $23M | 6 |
| COMMUNITY HOME HEALTH SERVICES INC | Fishers | E92 Health Care | $23M | 10 |
| INDIANA SPORTS CORPORATION | Indianapolis | N70 Recreation & Sports | $22.8M | 7 |
| NATIONAL ASSOCIATION OF MUTUAL | Indianapolis | — | $22.6M | 11 |
| JOHN H BONER COMMUNITY CENTER INC | Indianapolis | — | $22.6M | 3 |
| INDIANA STATE TEACHERS ASSOCIATION | Indianapolis | J40 Employment | $22.2M | 10 |
| Conner Prairie Museum Inc | Fishers | A54 Arts, Culture & Humanities | $22.1M | 7 |
| LOCAL 212 IBEW HEALTH & WELFARE | Indianapolis | — | $22.1M | 4 |
| KNOX COUNTY ASSOCIATION FOR | Vincennes | P82Z Human Services | $22M | 3 |
| Gibault Inc | Terre Haute | B280 Education | $21.9M | 4 |
| NORTHEASTERN CENTER INC | Kendallville | F30Z Mental Health & Crisis Intervention | $21.8M | 9 |
| ALPHA CHI OMEGA NATIONAL HOUSING | Indianapolis | — | $21.7M | 2 |
| DEKKO FOUNDATION INC | Kendallville | — | $21.7M | 1 |
| MIAMI-CASS COUNTY RURAL ELECTRIC | Peru | — | $21.7M | 13 |
| Community Foundation of St Joseph County Inc | South Bend | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $21.6M | 3 |
