| ARTS UNITED OF GREATER FORT WAYNE | Fort Wayne | A260 Arts, Culture & Humanities | $21.5M | 2 |
| FAMILY DEVELOPMENT SERVICES INC | Indianapolis | J20 Employment | $21.5M | 2 |
| FOOD BANK OF NORTHWEST | Merrillville | K31Z Food, Agriculture & Nutrition | $21.2M | 1 |
| Christel House International Inc | Indianapolis | Q30 International, Foreign Affairs & National Security | $21.1M | 9 |
| DEACONESS SPECIALTY PHYSICIANS INC | Evansville | E32 Health Care | $21.1M | 11 |
| INTERLOCAL COMMUNITY ACTION PROGRAM INC | New Castle | P20Z Human Services | $21.1M | 1 |
| 21st Century Charter School of Gary co GEO Foundation | Indianapolis | B29 Education | $21.1M | 0 |
| Lasting Change INC | Fort Wayne | I440 Crime & Legal-Related | $21M | 8 |
| OUR HOSPICE OF SOUTH | Columbus | P74I Human Services | $20.8M | 6 |
| FOOD FINDERS FOOD BANK INC | Lafayette | K31Z Food, Agriculture & Nutrition | $20.7M | 1 |
| EVANSVILLE GOODWILL INDUSTRIES INC | Evansville | J32Z Employment | $20.6M | 5 |
| CENTERSTONE HEALTH SERVICES INC | Bloomington | E32Z Health Care | $20.6M | 1 |
| INDIANA HEALTH INFORMATION EXCHANGE INC | Indianapolis | E112 Health Care | $20.4M | 17 |
| HABITAT FOR HUMANITY OF GREATER | Indianapolis | L20Z Housing & Shelter | $20.4M | 3 |
| THE DAMIEN CENTER | Indianapolis | P20 Human Services | $20.2M | 3 |
| INDIANAKENTUCKYOHIO REG COUNCIL OF | Warsaw | B30 Education | $20.1M | 7 |
| TRADEWINDS SERVICES INC | Merrillville | E500 Health Care | $20.1M | 8 |
| BALL STATE UNIVERSITY FOUNDATION INC | Muncie | B110 Education | $20M | 10 |
| THE ASSOCIATION OF ILLIANA CHRISTIAN HIGH SCHOOL OF INDIANA INC | Dyer | — | $20M | 4 |
| HOOSIER UPLANDS ECONOMIC DEVELOPMENT | Mitchell | S32Z Community Improvement & Capacity Building | $20M | 6 |
| Hubbard Hill Estates Inc | Elkhart | L22 Housing & Shelter | $19.9M | 5 |
| PLUMBERS AND STEAMFITTERS LOCAL 166 | Fort Wayne | — | $19.9M | 0 |
| 219 Health Network Inc | East Chicago | E22 Health Care | $19.8M | 2 |
| HERITAGE AND RESEARCH CENTER AT SAINT MARYS INC | Notre Dame | X22 Religion-Related | $19.8M | 0 |
| Indianapolis Private Industry Council | Indianapolis | J20Z Employment | $19.7M | 5 |
| DEACONESS ILLINOIS SPECIALTY CLINIC INC | Evansville | E30 Health Care | $19.6M | 9 |
| COMMUNITY HEALTH NETWORK FOUNDATION | Indianapolis | E122 Health Care | $19.6M | 11 |
| INDIANA PLASTERERS & CEMENT MASONS | Indianapolis | — | $19.5M | 1 |
| BOARD OF CERTIFIED SAFETY PROFESSIONALS | Indianapolis | S41Z Community Improvement & Capacity Building | $19.4M | 10 |
| CANTERBURY SCHOOL INC | Fort Wayne | B20Z Education | $19.4M | 2 |
| USA FOOTBALL INC | Indianapolis | N70 Recreation & Sports | $19.4M | 8 |
| RIGGS COMMUNITY HEALTH CENTER INC | Lafayette | E20Z Health Care | $19.4M | 7 |
| Anthem Supplemental Unemployment Benefit Trust | Indianapolis | Y24 Mutual & Membership Benefit | $19.3M | 1 |
| The Gibault Foundation Inc | Terre Haute | B110 Education | $19.1M | 1 |
| Eskenazi Health Foundation Inc | Indianapolis | E02 Health Care | $19.1M | 5 |
| EARLY LEARNING INDIANA INC | Indianapolis | P330 Human Services | $18.9M | 7 |
| CENTRAL INDIANA EDUCATIONAL SERVICE CENT | Indianapolis | B02 Education | $18.9M | 1 |
| DirectEmployers Association Inc | Indianapolis | Y03 Mutual & Membership Benefit | $18.8M | 8 |
| COMMUNITY FOUNDATION ALLIANCE INC | Evansville | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $18.8M | 2 |
| Indiana University Health Blackford Hospital Inc | Indianapolis | E22 Health Care | $18.7M | 17 |
| SAM SHINE FOUNDATION INC | Greenville | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $18.7M | 1 |
| AMERICAN COLLEGE OF SPORTS MEDICINE | Indianapolis | B54Z Education | $18.6M | 9 |
| MARSHALL COUNTY RURAL ELECTRIC MEMBERSHIP CORP | Plymouth | W80 Public & Societal Benefit | $18.6M | 15 |
| SOUTH BEND MEDICAL FOUNDATION | South Bend | E600 Health Care | $18.4M | 9 |
| AWS FOUNDATION INC | Fort Wayne | P82 Human Services | $18.4M | 4 |
| BLUE RIVER SERVICES INC | Corydon | — | $18.4M | 3 |
| LAGRANGE COUNTY RURAL ELECTRIC | LaGrange | — | $18.4M | 13 |
| HUMAN SERVICES INC | Columbus | — | $18.3M | 1 |
| SYCAMORE REHABILITATION SERVICES | Danville | P820 Human Services | $18.3M | 3 |
| GRANT-BLACKFORD MENTAL HEALTH INC | Marion | — | $18.2M | 11 |
