| MERCY HOSPITAL LEBANON | Lebanon | E22Z Health Care | $110.6M | 14 |
| MID-AMERICA TRANSPLANT SERVICES | St Louis | E65 Health Care | $108.1M | 17 |
| ARC OF THE OZARKS | Springfield | — | $108.1M | 9 |
| ASCENSION VIA CHRISTI HOSPITAL MANHATTAN INC | St Louis | E220 Health Care | $107.9M | 11 |
| STOWERS INSTITUTE FOR MEDICAL RESEARCH | Kansas City | H92 Medical Research | $107.5M | 13 |
| THE FOUNDATION FOR BARNES-JEWISH HOSPITAL | St Louis | E11 Health Care | $106.3M | 3 |
| Northeast Missouri Electric Power Coop | Palmyra | — | $106.1M | 26 |
| ST MARYS MEDICAL GROUP LLC | St Louis | E31 Health Care | $106.1M | 20 |
| EASTER SEALS MIDWEST | Saint Louis | — | $105.5M | 11 |
| Saint Thomas Regional Hospitals | St Louis | — | $105M | 15 |
| Advocates For a Healthy Community Inc | Springfield | E30Z Health Care | $104.2M | 18 |
| Veterans of Foreign Wars of The United States | Kansas City | — | $103.3M | 27 |
| CENTRAL INDIANA HEALTH SYSTEM CARDIAC SERVICES INC | St Louis | — | $102.9M | 12 |
| HALL FAMILY FOUNDATION | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $102.8M | 1 |
| ASCENSION MEDICAL GROUP PROMED | St Louis | E31Z Health Care | $102.5M | 22 |
| The Missouri Foundation for Health | St Louis | E70 Health Care | $102.4M | 9 |
| FAMILY COUNSELING CENTER INC | Kennett | P46Z Human Services | $99.2M | 7 |
| ST LOUIS AREA FOOD BANK INC | Bridgeton | — | $99M | 3 |
| PLUMBERS' & PIPEFITTERS' WELFARE EDUCATIONAL FUND | Earth City | — | $93.4M | 13 |
| ST LUKE'S MEDICAL GROUP | Chesterfield | — | $93.2M | 11 |
| St John Broken Arrow Inc | St Louis | E22 Health Care | $92M | 9 |
| ST LOUIS COMMUNITY FOUNDATION INC | St Louis | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $90.3M | 8 |
| NATIONAL INSURANCE PRODUCER REGISTRY DBA NIPR | Kansas City | — | $89.8M | 12 |
| Drury University | Springfield | B420 Education | $89.4M | 15 |
| Mosaic Medical Center Maryville | Saint Joseph | E22 Health Care | $87.9M | 13 |
| ST LUKE'S DES PERES EPISCOPAL- PRESBYTERIAN HOSPITAL | Chesterfield | E22 Health Care | $87.7M | 9 |
| LEGGETT & PLATT INCORPORATED EMPLOYEE BENEFIT FUND | Carthage | — | $86.9M | 0 |
| CONSTRUCTION INDUSTRY LABORERS WELFARE FUND | Kansas City | — | $86.5M | 0 |
| SWOPE HEALTH SERVICES | Kansas City | E300 Health Care | $85.6M | 11 |
| Alexian Brothers Ambulatory Group | St Louis | E30 Health Care | $84.3M | 6 |
| KVC BEVAVIORAL HEALTHCARE MISSOURI INC | Kansas City | — | $83.1M | 10 |
| LACLEDE ELECTRIC COOPERATIVE | Lebanon | — | $82.6M | 18 |
| VANTAGE CREDIT UNION | St Charles | — | $82.1M | 13 |
| SOUTHWEST ELECTRIC COOPERATIVE | Bolivar | — | $81.7M | 15 |
| UNITED WAY OF GREATER ST LOUIS INC | Saint Louis | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $81.4M | 10 |
| GATEWAY REGION YOUNG MEN'S CHRISTIAN ASSOCIATION | Saint Louis | P270 Human Services | $81.3M | 10 |
| PARK UNIVERSITY | Parkville | B430 Education | $80.9M | 20 |
| MERCY HOSPITAL CARTHAGE | Carthage | — | $80.8M | 14 |
| Ozark Electric Cooperative Inc | Mount Vernon | — | $80.4M | 19 |
| UNITED STATES SOYBEAN EXPORT COUNCIL INC | Chesterfield | S40 Community Improvement & Capacity Building | $80.4M | 18 |
| St Vincent Fishers Hospital Inc | St Louis | E22 Health Care | $79.9M | 14 |
| Rediscover | Lees Summit | — | $79.1M | 13 |
| MERCY HEALTH EAST COMMUNITIES | Chesterfield | X00Z Religion-Related | $78.8M | 14 |
| Alexian Brothers Behavioral Health Hospital | St Louis | — | $78M | 8 |
| JOHN KNOX VILLAGE | Lees Summit | P750 Human Services | $77M | 12 |
| SetonUT Austin Dell Medical School University Physicians Group | St Louis | E30 Health Care | $76.6M | 9 |
| Boone Electric Cooperative | Columbia | — | $76.4M | 21 |
| AMEREN HEALTH AND WELFARE TRUST | Saint Louis | — | $75.4M | 1 |
| BOARD OF TRUSTEES OF IBEW LOCAL 1 HEALTH & WELFARE FUND | St Louis | — | $75.3M | 0 |
| MISSOURI BOTANICAL GARDEN BOARD OF TRUSTEES | St Louis | C410 Environment | $75.3M | 13 |
