| Saint Lukes Health System Home Care and Hospice | Kansas City | E21 Health Care | $71.9M | 14 |
| LEGGETT & PLATT INCORPORATED EMPLOYEE BENEFIT FUND | Carthage | — | $71.4M | 0 |
| WELFARE FUND OF ENGINEERS LOCAL UNION | Bridgeton | — | $71.3M | 0 |
| COX-MONETT HOSPITAL INC | Monett | E22 Health Care | $71M | 11 |
| Evangel University | Springfield | B420 Education | $70M | 5 |
| CONSTRUCTION INDUSTRY LABORERS WELFARE | Kansas City | — | $69.6M | 0 |
| Greater Horizons Trust | Kansas City | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $69.6M | 0 |
| Mary Institute and St Louis Country Day | St Louis | B200 Education | $69.3M | 7 |
| Saint Luke's Hospital of Chillicothe | Chillicothe | E21 Health Care | $69M | 16 |
| FAMILY COUNSELING CENTER INC | Kennett | P46Z Human Services | $68.2M | 4 |
| PRESENCE SENIOR SERVICES CHICAGOLAND | St Louis | E910 Health Care | $68.1M | 13 |
| Providence Health Alliance | St Louis | E30 Health Care | $67.5M | 19 |
| VANTAGE CREDIT UNION | St Charles | — | $67.4M | 15 |
| INTERCOUNTY ELECTRIC COOPERATIVE | Licking | — | $66.8M | 15 |
| ALPHAPOINTE | Kansas City | J33 Employment | $66.5M | 8 |
| BOARD OF TRUSTEES GREATER ST LOUIS | St Louis | — | $66.4M | 3 |
| St John Broken Arrow Inc | St Louis | E22 Health Care | $66.4M | 8 |
| INTERNATIONAL ASSOC OF MACHINISTS | Bridgeton | — | $66.3M | 0 |
| DONALD DANFORTH PLANT SCIENCE CENTER | Saint Louis | U500 Science & Technology | $65.7M | 12 |
| CAMERON REGIONAL MEDICAL CENTER | Cameron | E220 Health Care | $65.2M | 11 |
| CARDINAL GLENNON CHILDREN'S FOUNDATION | St Louis | — | $65.1M | 6 |
| Mercy Hospital Carthage | Carthage | — | $64.6M | 13 |
| THE SAINT LOUIS ZOO ASSOCIATION | Saint Louis | D115 Animal-Related | $63.3M | 10 |
| Mercy Health Southwest MissouriKansas Communities | Joplin | — | $62.9M | 12 |
| JOHN FITZGIBBON MEMORIAL HOSPITAL | Marshall | E220 Health Care | $62.9M | 9 |
| FRIENDSHIP VILLAGE OF SOUTH COUNTY | St Louis | P750 Human Services | $61.5M | 9 |
| INTERNATIONAL BROTHERHOOD OF | Kansas City | — | $61.4M | 13 |
| OPERATING ENGINEERS LOCAL 101 | Kansas City | — | $61.1M | 2 |
| Ozark Center | Joplin | F31Z Mental Health & Crisis Intervention | $60.1M | 11 |
| INTERNATIONAL BROTHERHOOD OF ELETRL | Kansas City | — | $59.6M | 0 |
| CONSORTIUM FOR GRADUATE STUDY IN | Chesterfield | — | $59.2M | 4 |
| Alexian Brothers Specialty Group | St Louis | E31 Health Care | $59.1M | 8 |
| KIPP ST LOUIS | St Louis | — | $58.9M | 4 |
| THE FOUNDATION FOR BARNES-JEWISH | St Louis | E11 Health Care | $58.8M | 4 |
| Center for Human Services Inc | Sedalia | — | $58.7M | 7 |
| MISSOURI BAPTIST UNIVERSITY | St Louis | B420 Education | $58.6M | 12 |
| COMMUNITY FOUNDATION OF THE OZARKS INC | Springfield | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $57.7M | 4 |
| CENTRAL METHODIST UNIVERSITY | Fayette | B420 Education | $57.5M | 11 |
| CORNERSTONES OF CARE | Kansas City | P19 Human Services | $57.5M | 6 |
| Cox Health Systems HMO Inc | Springfield | E21 Health Care | $57.4M | 12 |
| GOODWILL OF WESTERN MISSOURI & EASTERN KANSAS | Kansas City | J320 Employment | $57.2M | 8 |
| UNITED FOOD AND COMMERCIAL WORKERS | Ballwin | — | $57.1M | 0 |
| Missouri Hospital Plan | Jefferson City | — | $56.7M | 7 |
| CONFLUENCE ACADEMY | St Louis | B20 Education | $56.4M | 7 |
| Black River Electric Cooperative | Fredericktown | — | $56M | 14 |
| ASCENSION ST JOSEPH HOSPITAL | St Louis | E20 Health Care | $56M | 16 |
| ASCENSION VIA CHRISTI HOSPITAL ST TERESA INC | St Louis | E22 Health Care | $55M | 14 |
| WESTMINSTER COLLEGE | Fulton | B420 Education | $53.9M | 7 |
| FRIENDS OF THE ZOO INC OF KANSAS CITY | Kansas City | D115 Animal-Related | $53.6M | 9 |
| THE LIGHTHOUSE FOR THE BLIND | St Louis | — | $53.1M | 8 |
