| TRUSTEES OF CLARK UNIVERSITY | Worcester | B430 Education | $249.6M | 17 |
| NEIGHBORHEALTH CORPORATION | East Boston | E320 Health Care | $247.9M | 9 |
| PARTNERS IN HEALTH A NONPROFIT CORPORATION | Boston | E70 Health Care | $238.3M | 9 |
| Combined Jewish Philanthropies of Greater Boston Inc | Boston | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $231.1M | 13 |
| VINFEN CORPORATION | Cambridge | P800 Human Services | $229.7M | 13 |
| SIMMONS UNIVERSITY | Boston | B430 Education | $225M | 12 |
| CLINTON HEALTH ACCESS INITIATIVE INC | Boston | Q33 International, Foreign Affairs & National Security | $224.7M | 13 |
| WGBH Educational Foundation | Boston | A300 Arts, Culture & Humanities | $220.6M | 16 |
| ELIOT COMMUNITY HUMAN SERVICES INC | Lexington | F32 Mental Health & Crisis Intervention | $219.9M | 7 |
| NEW ENGLAND BAPTIST HOSPITAL | Charlestown | E220 Health Care | $219.3M | 25 |
| EDUCATION DEVELOPMENT CENTER INC | Waltham | — | $210.8M | 13 |
| TEAMSTERS UNION LOCAL 25 HEALTH SERVICES | Charlestown | — | $202.8M | 10 |
| KAISER FOUNDATION HEALTH PLAN INC | Heritage Dr N Qu | Y20 Mutual & Membership Benefit | $202.6M | 1 |
| MASSACHUSETTS LABORERS' HEALTH & WELFARE | Burlington | — | $199.9M | 6 |
| BAYSTATE ADMINISTRATIVE SERVICES INC | Springfield | E210 Health Care | $199M | 14 |
| STONEHILL COLLEGE INC | Easton | B420 Education | $197.2M | 12 |
| ENDICOTT COLLEGE | Beverly | B430 Education | $195.9M | 11 |
| POPPLESTONE FOUNDATION | Boston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $194.6M | 0 |
| WENTWORTH INSTITUTE OF TECHNOLOGY INC | Boston | B430 Education | $193.5M | 19 |
| HULT INTERNATIONAL BUSINESS SCHOOL INC | Cambridge | B51Z Education | $193.2M | 10 |
| Henry Heywood Memorial Hospital | Gardner | E220 Health Care | $191.9M | 13 |
| BARR FOUNDATION | Boston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $191.8M | 1 |
| COMMUNITY TEAMWORK INC | Lowell | P200 Human Services | $188.3M | 5 |
| TRUSTEES OF PHILLIPS ACADEMY | Andover | B250 Education | $186.8M | 13 |
| ACTION INC | Gloucester | P200 Human Services | $184.3M | 10 |
| BEHAVIORAL HEALTH NETWORK INC | Springfield | F300 Mental Health & Crisis Intervention | $183.3M | 16 |
| COMMUNITY DAY CARE CENTER OF | Lawrence | — | $183.3M | 7 |
| GREATER BOSTON FOOD BANK INC | Boston | — | $173.4M | 10 |
| METRO CREDIT UNION | Chelsea | — | $173.4M | 14 |
| WESTERN NEW ENGLAND UNIVERSITY | Springfield | B430 Education | $169.8M | 9 |
| SOUTH MIDDLESEX OPPORTUNITY COUNCIL INC | Framingham | P200 Human Services | $169.3M | 10 |
| Hebrew Rehabilitation Center | Boston | E910 Health Care | $168.9M | 19 |
| CITY YEAR INC | Boston | Z99Z Unknown | $168.2M | 12 |
| MathWorks Foundation Inc | Natick | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $167.2M | 0 |
| BETH ISRAEL DEACONESS HOSPITAL - MILTON | Charlestown | E220 Health Care | $166.9M | 24 |
| BRIGHTON MARINE INC | Brighton | E22Z Health Care | $165.2M | 3 |
| THE RARE DISEASE CHARITABLE FOUNDATION | Lexington | — | $162.8M | 0 |
| CAPE COD HEALTHCARE INC | Hyannis | E210 Health Care | $162.7M | 20 |
| HEALTH AND WELFARE TRUST FUND | Boston | — | $162.1M | 4 |
| Boston Foundation Inc | Boston | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $161.3M | 17 |
| BETH ISRAEL DEACONESS HOSPITAL - NEEDHAM | Charlestown | E22 Health Care | $161.3M | 19 |
| CHMC Anesthesia Foundation Inc | Boston | G900 Diseases, Disorders & Medical Disciplines | $159.8M | 20 |
| SPRINGFIELD COLLEGE | Springfield | B430 Education | $158.2M | 19 |
| CAMBRIDGE HEALTH ALLIANCE PHYSICIANS | Malden | E31Z Health Care | $155.8M | 12 |
| WHEATON COLLEGE | Norton | B420 Education | $154.3M | 16 |
| YEAR UP INC | Boston | B41 Education | $151.9M | 19 |
| THE MAY INSTITUTE INC | Randolph | F300 Mental Health & Crisis Intervention | $149.7M | 13 |
| ADVOCATES INC | Framingham | F320 Mental Health & Crisis Intervention | $147.5M | 11 |
| ANNA JAQUES HOSPITAL INC | Charlestown | E220 Health Care | $145.8M | 29 |
| BAY COVE HUMAN SERVICES INC | Boston | — | $144.9M | 12 |
