| CORNERSTONE FAMILY HEALTHCARE | Cornwall | E32Z Health Care | $73.4M | 10 |
| OPEN DOOR FAMILY MEDICAL CENTER INC | Ossining | E320 Health Care | $73.1M | 9 |
| UFCW LOCAL ONE HEALTH CARE FUND | Oriskany | Y43 Mutual & Membership Benefit | $73.1M | 7 |
| POLY PREP COUNTRY DAY SCHOOL | Brooklyn | B200 Education | $73M | 13 |
| Ludwig Institute for Cancer Research Ltd | New York | — | $72.9M | 19 |
| SUNMARK CREDIT UNION | Latham | W61 Public & Societal Benefit | $72.9M | 21 |
| CFCU COMMUNITY CREDIT UNION | Ithaca | — | $72.9M | 11 |
| CHAUTAUQUA COUNTY CHAPTER OF NYSARC INC | Jamestown | P82Z Human Services | $72.9M | 8 |
| LONG ISLAND JEWISH MEDICAL CENTER | Westbury | E99Z Health Care | $72.5M | 17 |
| FOODLINK INC | Rochester | K30 Food, Agriculture & Nutrition | $72.3M | 8 |
| TOURO UNIVERSITY NEVADA | New York | B50 Education | $72.1M | 17 |
| THE STEVE TISCH FAMILY FOUNDATION | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $72.1M | 0 |
| THE ADVERTISING COUNCIL INC | New York | — | $71.8M | 20 |
| NEW HOPE COMMUNITY INC | Loch Sheldrake | P700 Human Services | $71.7M | 9 |
| WILLIAM F RYAN COMMUNITY HEALTH | New York | E320 Health Care | $71.6M | 12 |
| CARDINAL MCCLOSKEY SCHOOL AND HOME FOR | Valhalla | — | $71.5M | 8 |
| PACKER COLLEGIATE INSTITUTE | Brooklyn | B200 Education | $71.5M | 13 |
| EQUITY-LEAGUE HEALTH TRUST FUND | New York | — | $71.4M | 6 |
| Steamfitters Industry Welfare Fund | Long Island City | J40 Employment | $71.4M | 9 |
| COMMON GROUND MANAGEMENT CORP | New York | J20 Employment | $71.3M | 10 |
| THE JONATHAN M TISCH FAMILY FOUNDATION | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $71.3M | 0 |
| SAMUEL FIELD YM-YWHA INC | Little Neck | P270 Human Services | $71.3M | 9 |
| NATIONAL SOCIETY FOR HEBREW DAY SCHOOLS | Brooklyn | X300 Religion-Related | $71.1M | 6 |
| CITIZENS OPTIONS UNLIMITED INC | Brookville | — | $71M | 6 |
| Stony Brook Childrens Services University Faculty Practice Corporation | Stony Brook | E20 Health Care | $71M | 9 |
| NEW YORK ATHLETIC CLUB | New York | — | $70.9M | 8 |
| ROCKEFELLER BROTHERS FUND INC | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $70.8M | 6 |
| THE SCHULMAN AND SCHACHNE INSTITUTE FOR | Brooklyn | E910 Health Care | $70.6M | 12 |
| HEALTH AND WELFARE FUND OF THE PBA OF TH | New York | — | $70.2M | 6 |
| PER SCHOLAS INC | Bronx | J12 Employment | $70M | 8 |
| ROUNDABOUT THEATRE COMPANY INC | New York | A650 Arts, Culture & Humanities | $69.9M | 11 |
| Garnet Health Doctors PC | Middletown | E60 Health Care | $69.6M | 9 |
| VITAL STRATEGIES INC | New York | Q30 International, Foreign Affairs & National Security | $69.5M | 11 |
| IBEW LOCAL 1249 INSURANCE FUND | Cicero | — | $69.3M | 1 |
| DKMS | New York | E65 Health Care | $69.1M | 5 |
| Stony Brook Surgical Associates University Faculty Practice Corporation | Stony Brook | E20 Health Care | $69M | 10 |
| SAINT DOMINIC'S FAMILY SERVICES | Blauvelt | — | $69M | 8 |
| PEPSICO FOUNDATION INC | Purchase | — | $68.9M | 0 |
| BROOKS-TLC HOSPITAL SYSTEM | Dunkirk | E220 Health Care | $68.9M | 6 |
| EMPOWERING ECONOMIC GROWTH FOUNDATION | New York | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $68.6M | 0 |
| LIFE'S WORC INC | Garden City | P700 Human Services | $68.3M | 13 |
| AFRICAN AMERICAN PLANNING COMMISSION INC | Brooklyn | P20 Human Services | $68.3M | 5 |
| METROPOLITAN JEWISH HEALTH SYSTEM INC | New York | E19 Health Care | $68.1M | 8 |
| BLACK VETERANS FOR SOCIAL JUSTICE | Brooklyn | W300 Public & Societal Benefit | $67.9M | 4 |
| BERKSHIRE FARM CENTER AND SERVICES FOR | Canaan | P730 Human Services | $67.8M | 8 |
| New York Municipal Power Agency | East Syracuse | Y22 Mutual & Membership Benefit | $67.7M | 1 |
| BAKER HALL | Lackawanna | B99 Education | $67.6M | 7 |
| TRINITY MEDICAL WNY PC | Buffalo | E30 Health Care | $67.5M | 8 |
| YMCA OF GREATER ROCHESTER (4368) | Rochester | P270 Human Services | $67.3M | 8 |
| COMUNILIFE INC | New York | Z99Z Unknown | $67.2M | 8 |
