| PER SCHOLAS INC | Bronx | J12 Employment | $70M | 8 |
| CHINESE-AMERICAN PLANNING COUNCIL INC | New York | P840 Human Services | $69.9M | 10 |
| BROOKS-TLC HOSPITAL SYSTEM | Dunkirk | E220 Health Care | $69.6M | 6 |
| Garnet Health Doctors PC | Middletown | E60 Health Care | $69.6M | 9 |
| ABBOTT HOUSE | Irvington | P73Z Human Services | $69.5M | 10 |
| IBEW LOCAL 1249 INSURANCE FUND | Cicero | — | $69.3M | 1 |
| William Randolph Hearst Foundation | New York | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $69.1M | 2 |
| DKMS | New York | E65 Health Care | $69.1M | 5 |
| EMPOWERING ECONOMIC GROWTH FOUNDATION | New York | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $68.6M | 0 |
| THE BROOKLYN INSTITUTE OF ARTS AND SCIENCES | Brooklyn | A510 Arts, Culture & Humanities | $68.3M | 16 |
| THE BREARLEY SCHOOL | New York | B200 Education | $68.2M | 8 |
| BROOKLYN PROSPECT CHARTER SCHOOL | Brooklyn | B29 Education | $68.2M | 5 |
| HAMASPIK OF ROCKLAND COUNTY INC | Monsey | Z99 Unknown | $67.9M | 12 |
| LYCEE FRANCAIS DE NEW YORK | New York | B200 Education | $67.8M | 9 |
| Siegel Family Endowment | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $67.6M | 1 |
| South Nassau Communities Hospital | Oceanside | — | $67.5M | 22 |
| THE INSTITUTES OF APPLIED HUMAN DYNAMICS | Tarrytown | P82 Human Services | $67.5M | 9 |
| TRINITY MEDICAL WNY PC | Buffalo | E30 Health Care | $67.5M | 8 |
| Stony Brook Childrens Services University Faculty Practice Corporation | Stony Brook | E20 Health Care | $67.3M | 8 |
| FOLLOW YOUR DREAM FOUNDATION INC | New York | Q70 International, Foreign Affairs & National Security | $67.2M | 3 |
| FUND FOR THE CITY OF NEW YORK INC | New York | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $67M | 28 |
| ABRAHAM JOSHUA HESCHEL SCHOOL | New York | B200 Education | $66.7M | 8 |
| PRO MUJER INC | New York | Q300 International, Foreign Affairs & National Security | $66.7M | 7 |
| ALLIED CLIMATE PARTNERS INC | New York | C02 Environment | $66.5M | 3 |
| THE DOE FUND INC | New York | L210 Housing & Shelter | $66.4M | 10 |
| OPEN DOOR FAMILY MEDICAL CENTER INC | Ossining | E320 Health Care | $66.4M | 9 |
| St Vincent's Services Inc | Brooklyn | P320 Human Services | $66.3M | 8 |
| THE ACTORS' FUND OF AMERICA | New York | Y400 Mutual & Membership Benefit | $66.1M | 11 |
| GOVERNORS ISLAND CORPORATION | New York | D30 Animal-Related | $66.1M | 9 |
| RETIREE HEALTH AND WELFARE FUND OF THE PBA OF THE CITY OF NEW YORK | New York | — | $65.9M | 6 |
| CHARINA ENDOWMENT FUND INC | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $65.7M | 0 |
| THE CHAPIN SCHOOL LTD | New York | B200 Education | $65.7M | 8 |
| CONCERN WORLDWIDE (US) INC | New York | Q300 International, Foreign Affairs & National Security | $65.7M | 7 |
| WORD OF LIFE FELLOWSHIP INC | Schroon Lake | X200 Religion-Related | $65.6M | 8 |
| LIFE'S WORC INC | Garden City | P700 Human Services | $65.6M | 12 |
| Stony Brook Surgical Associates University Faculty Practice Corporation | Stony Brook | E20 Health Care | $65.6M | 9 |
| THE BRONX DEFENDERS | Bronx | I80 Crime & Legal-Related | $65.5M | 14 |
| THE CENTER FOR REPRODUCTIVE RIGHTS INC | New York | R610 Civil Rights, Social Action & Advocacy | $65.4M | 14 |
| BAKER HALL | Lackawanna | B99 Education | $65.3M | 7 |
| NEW YORK STATE NURSES ASSOCIATION | New York | — | $65.2M | 24 |
| THE DERFNER FOUNDATION | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $65.1M | 1 |
| GENESEE-LIVINGSTON-ORLEANS-WYOMING COUNTIES NYSARC INC D/B/A ARC GLOW | Mt Morris | P820 Human Services | $65M | 7 |
| PREMIUM HEALTH INC | Brooklyn | E32 Health Care | $65M | 16 |
| Hudson Valley Cardiovascular Practice PC | Poughkeepsie | E22 Health Care | $64.9M | 11 |
| Consolidated Edison of NY Inc Master VEBA Retiree Health Trust | New York | — | $64.9M | 1 |
| CITIZEN ADVOCATES INC | Malone | P800 Human Services | $64.8M | 10 |
| JEWISH HOME OF ROCHESTER | Rochester | E910 Health Care | $64.8M | 8 |
| Cancer Care Co-Payment Assistance Foundation Inc | New York | E118 Health Care | $64.7M | 6 |
| THE COLLEGE OF SAINT ROSE | Albany | B430 Education | $64.6M | 9 |
| RUBIO BUTTERFIELD FOUNDATION | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $64.4M | 0 |
