| WHYY INC | Philadelphia | A300 Arts, Culture & Humanities | $48.1M | 14 |
| THE BRETHREN HOME COMMUNITY | New Oxford | P750 Human Services | $48.1M | 8 |
| Cen-Clear Child Services Inc | Woodland | P300 Human Services | $48.1M | 7 |
| YMCA OF GREATER BRANDYWINE | West Chester | P27 Human Services | $47.9M | 11 |
| Keyspan Corp Life Ins Master Trust | Pittsburgh | Y43 Mutual & Membership Benefit | $47.7M | 1 |
| CROATIAN FRATERNAL UNION OF AMERICA | Pittsburgh | P84Z Human Services | $47.6M | 15 |
| ANABAPTIST FINANCIAL | Lewisburg | W60 Public & Societal Benefit | $47.4M | 5 |
| CARNEGIE LIBRARY OF PITTSBURGH | Pittsburgh | B70 Education | $47.3M | 8 |
| CO-MHAR Inc | Philadelphia | F30Z Mental Health & Crisis Intervention | $47.1M | 10 |
| ACCESS SERVICES INC | Fort Washington | — | $47.1M | 7 |
| MANN CENTER FOR THE PERFORMING ARTS | Philadelphia | A610 Arts, Culture & Humanities | $46.9M | 6 |
| NATIONAL HOCKEY LEAGUE PLAYERS' HEALTH AND | Pittsburgh | Y44 Mutual & Membership Benefit | $46.9M | 0 |
| LYCOMING COUNTY INSURANCE | Canton | — | $46.6M | 0 |
| Northeast Pennsylvania School Districts Health Trust | Edwardsville | Y43 Mutual & Membership Benefit | $46.6M | 0 |
| Pacific Gas & Electric Post Ret Med Pl Tr | Pittsburgh | — | $46.5M | 1 |
| UNION COMMUNITY CARE | Lancaster | E34Z Health Care | $46.5M | 10 |
| STEAMFITTERS 449 MEDICAL & BENEFIT | Harmony | — | $46.4M | 0 |
| UNITED STATES CATHOLIC CONFERENCE | New Brighton | P700 Human Services | $46.2M | 11 |
| Radiology Associates of Children's | Philadelphia | E31 Health Care | $46M | 12 |
| Tri-County Electric Cooperative Inc | Mansfield | — | $45.9M | 19 |
| LANCASTER BIBLE COLLEGE | Lancaster | B58Z Education | $45.7M | 7 |
| RIVER CROSSING YOUNG MEN'S | Doylestown | P27Z Human Services | $45.6M | 10 |
| ARC HUMAN SERVICES INC | Canonsburg | P82Z Human Services | $45.5M | 5 |
| TRUMERIT | Philadelphia | E60 Health Care | $45.3M | 8 |
| Eversource Retirees Benefit Trust | Pittsburgh | — | $45M | 1 |
| PENNSYLVANIA COALITION AGAINST | Harrisburg | — | $44.8M | 7 |
| MILLCREEK MANOR | Erie | E91Z Health Care | $44.5M | 10 |
| NSABP FOUNDATION INC | Pittsburgh | H300 Medical Research | $44.2M | 11 |
| HAMILTON FAMILY CHARITABLE TRUST | Wayne | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $43.9M | 5 |
| THE WRIGHT CENTER FOR GRADUATE MEDICAL | Scranton | G95Z Diseases, Disorders & Medical Disciplines | $43.8M | 16 |
| OVERBROOK SCHOOL FOR THE BLIND | Philadelphia | B280 Education | $43.8M | 7 |
| NORTHERN TIER INSURANCE CONSORTIUM | Canton | Y43 Mutual & Membership Benefit | $43.6M | 0 |
| CHILDRENS SVC CTR OF WYOM VALLEY INC | Wilkes Barre | F300 Mental Health & Crisis Intervention | $43.5M | 22 |
| CCRES | Downingtown | B19 Education | $43.4M | 7 |
| ZOOLOGICAL SOCIETY OF PHILADELPHIA | Philadelphia | D500 Animal-Related | $43.4M | 14 |
| NORTHWEST INSTITUTE OF RESEARCH | Erie | — | $43.4M | 3 |
| FOULKEWAYS AT GWYNEDD | Gwynedd | P750 Human Services | $43.3M | 9 |
| ALBERT EINSTEIN HEALTHCARE NETWORK | Philadelphia | E120 Health Care | $43.2M | 0 |
| FAMILY CARE CENTERS INC | Allentown | — | $43.1M | 25 |
| LOCAL 8-86 MERCK EMPLOYEES VEBA TRUST | Horsham | — | $42.9M | 0 |
| JEVS CARE AT HOME | Philadelphia | P44 Human Services | $42.6M | 6 |
| J N PEW JR CHARITABLE TRUST | Philadelphia | — | $42.6M | 1 |
| Fulton Financial Corp Employee | Lancaster | — | $42.5M | 0 |
| BAPTIST HOMES SOCIETY | Pittsburgh | E91 Health Care | $42.5M | 6 |
| Great Lakes Physician Practice PC | Pittsburgh | E30 Health Care | $42.3M | 14 |
| HARCUM COLLEGE | Bryn Mawr | B420 Education | $42.3M | 6 |
| TRUSTEES OF THE UNIV OF PENNA RETIREE MED | Philadelphia | Y330 Mutual & Membership Benefit | $42.2M | 0 |
| LITTLE LEAGUE BASEBALL INCORPORATED | Williamsport | N630 Recreation & Sports | $42.2M | 14 |
| WHITE HORSE VILLAGE INC | Newtown Square | P750 Human Services | $41.9M | 12 |
| TEL HAI RETIREMENT COMMUNITY | Honey Brook | P75 Human Services | $41.8M | 7 |
