| EMERGENCY NURSES ASSOCIATION | Schaumburg | B60 Education | $29.3M | 21 |
| Trinity International University | Deerfield | B420 Education | $29.2M | 10 |
| BEVERLY FARM FOUNDATION | Godfrey | P730 Human Services | $29.1M | 3 |
| NORTH CENTRAL ILLINOIS LABORERS HEALTH & | Peoria | Y44 Mutual & Membership Benefit | $29.1M | 1 |
| NESS HEALTHCARE NFP | Lincolnwood | L22 Housing & Shelter | $29.1M | 12 |
| APOSTOLIC CHRISTIAN LIFEPOINTS INC | Morton | P82 Human Services | $29M | 7 |
| Alpha USA | Carol Stream | X21 Religion-Related | $28.9M | 11 |
| THE ADMIRAL AT THE LAKE | Chicago | P75 Human Services | $28.8M | 9 |
| NORTH SHORE COUNTRY DAY SCHOOL | Winnetka | — | $28.8M | 10 |
| LAWYERS TRUST FUND OF ILLINOIS | Chicago | T90Z Philanthropy, Voluntarism & Grantmaking Foundations | $28.7M | 3 |
| IIT RESEARCH INSTITUTE | Chicago | U200 Science & Technology | $28.7M | 11 |
| Womens Leadership Center | Chicago | B60 Education | $28.6M | 0 |
| RAY GRAHAM ASSOCIATION FOR PEOPLE | Lisle | Z99 Unknown | $28.5M | 7 |
| Carle Eureka Hospital | Urbana | E20 Health Care | $28.5M | 24 |
| TASC INC | Chicago | F220 Mental Health & Crisis Intervention | $28.5M | 11 |
| BRIDGEWAY INC | Galesburg | — | $28.5M | 0 |
| KENNETH YOUNG CENTER | Elk Grove Village | — | $28.4M | 5 |
| THE COCA-COLA COMPANY POSTRETIREMENT | Chicago | Y43 Mutual & Membership Benefit | $28.4M | 1 |
| EASTERN ILLINOIS FOODBANK | Urbana | K310 Food, Agriculture & Nutrition | $28.3M | 1 |
| Adams Electric Cooperative | Camp Point | — | $28.3M | 16 |
| AMERICAN SOCIETY FOR CLINICAL PATHOLOGY | Chicago | — | $28.2M | 19 |
| Greater Europe Mission | Wheaton | X20Z Religion-Related | $28.1M | 9 |
| CHADDOCK ATTACHMENT AND TRAUMA SERVICES | Quincy | — | $28M | 2 |
| Islamic Food & Nutrition Council of America | Des Plaines | — | $27.9M | 7 |
| FAMILY FOCUS | Chicago | P460 Human Services | $27.8M | 7 |
| Children's Hospital Of Chicago Faculty Practice Plan Inc | Chicago | — | $27.8M | 10 |
| CENTRAL LABORERS' WELFARE FUND | Jacksonville | — | $27.7M | 0 |
| INTERNATIONAL ASSOCIATION OF HEAT & | Tinley Park | — | $27.7M | 3 |
| AMERICAN FEDERATION OF TEACHERS | Westmont | — | $27.6M | 60 |
| CHINESE AMERICAN SERVICE LEAGUE INC | Chicago | S800 Community Improvement & Capacity Building | $27.5M | 7 |
| DESERT HEALTH CARE FACILITIES INC | Galesburg | E92 Health Care | $27.5M | 8 |
| INSTITUTE OF FOOD TECHNOLOGISTS | Chicago | — | $27.3M | 8 |
| ASSOCIATION FOR CORPORATE GROWTH | Chicago | — | $27.3M | 17 |
| ARCH IRONWORKERS LOCAL 63 WELFARE FUND | Oak Brook | — | $27.3M | 3 |
| STREATOR ONIZED CREDIT UNION | Streator | W61 Public & Societal Benefit | $27.3M | 12 |
| Community General Hospital Employee Benefit Trust | Sterling | — | $27.2M | 6 |
| THE JOSSELYN CENTER NFP | Northbrook | F60Z Mental Health & Crisis Intervention | $27.1M | 8 |
| LAWRENCE COUNTY MEMORIAL HOSPITAL | Lawrenceville | E20 Health Care | $27.1M | 9 |
| COVENANT HOME | Northbrook | P750 Human Services | $27.1M | 18 |
| ASSYRIAN NATIONAL COUNCIL OF ILLINOIS | Chicago | P200 Human Services | $26.9M | 8 |
| WASHINGTON AND JANE SMITH COMMUNITY - | Chicago | P750 Human Services | $26.9M | 5 |
| PEPCO HOLDINGS INC VEBA TRUST | Chicago | Y43 Mutual & Membership Benefit | $26.9M | 1 |
| AMERICAN FEDERATION OF STATE COUNTY AND | Springfield | — | $26.9M | 33 |
| WORD ON FIRE CATHOLIC MINISTRIES | Elk Grove Village | X81 Religion-Related | $26.9M | 8 |
| WILLIAM R KENAN JR CHARITABLE TRUST XXXXX2004 | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $26.8M | 3 |
| Lawrence Hall | Chicago | — | $26.8M | 8 |
| CHAPIN HALL CENTER FOR CHILDREN | Chicago | P70Z Human Services | $26.7M | 13 |
| FRANCES HOUSE INC | Galesburg | P750 Human Services | $26.7M | 4 |
| Wheaton Academy | West Chicago | B25Z Education | $26.7M | 7 |
| XILIN ASSOCIATION | Naperville | — | $26.7M | 3 |
