| MERCY HEALTH CORPORATION | Rockford | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $148.2M | 4 |
| National Louis University | Chicago | B430 Education | $146.3M | 9 |
| GOTTLIEB MEMORIAL HOSPITAL | Melrose Park | E220 Health Care | $146.2M | 18 |
| NORTHWESTERN UNIVERSITY MASTER WELFARE BENEFIT TRUST | Chicago | — | $145.2M | 1 |
| American Hospital Association | Chicago | — | $144.7M | 31 |
| Ronald McDonald House Charities Inc | Chicago | E860 Health Care | $144M | 0 |
| NATIONAL FUTURES ASSOCIATION | Chicago | — | $143.7M | 42 |
| EMPEOPLE CREDIT UNION | Moline | W61 Public & Societal Benefit | $142.6M | 16 |
| GIFT OF HOPE ORGAN & TISSUE DONOR NETWORK | Itasca | E65Z Health Care | $141.7M | 11 |
| AMERICAN COLLEGE OF SURGEONS | Chicago | B600 Education | $141.7M | 15 |
| Lake Forest College | Lake Forest | B420 Education | $141.5M | 17 |
| CHICAGO & VICINITY LABORERS' DISTRICT COUNCIL RETIREE HEALTH & WELFARE PLAN | Westchester | Y44 Mutual & Membership Benefit | $141.4M | 8 |
| AMERICAN ACADEMY OF PEDIATRICS | Itasca | G980 Diseases, Disorders & Medical Disciplines | $140.5M | 43 |
| ROCKFORD HEALTH PHYSICIANS | Rockford | E210 Health Care | $140.3M | 9 |
| HSHS Medical Group Inc | Springfield | — | $140.2M | 15 |
| CATERPILLAR INC GROUP INSURANCE MASTER TRUST AGREEMENT 22-46859 | Chicago | — | $138.6M | 1 |
| Proctor Hospital | Urbana | E220 Health Care | $138.3M | 16 |
| Rosalind Franklin University of Medicine and Science | North Chicago | — | $137.9M | 13 |
| THOREK MEMORIAL HOSPITAL | Chicago | E220 Health Care | $136.2M | 15 |
| National Council of State Boards of Nursing | Chicago | E030 Health Care | $136M | 8 |
| DUNARD FUND USA LTD | Northbrook | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $135M | 0 |
| Start Early | Chicago | — | $134.9M | 12 |
| GRAHAM HOSPITAL ASSOCIATION | Canton | E220 Health Care | $134.7M | 11 |
| IFF | Chicago | S500 Community Improvement & Capacity Building | $134.6M | 11 |
| Olivet Nazarene University | Bourbonnais | B430 Education | $134M | 14 |
| Deaconess Regional Healthcare Services Illinois | Marion | E80 Health Care | $133.3M | 6 |
| Franciscan Communities Inc | Lemont | — | $133M | 8 |
| Northwest Community Healthcare | Arlington Heights | E120 Health Care | $131.4M | 9 |
| MISERICORDIA HOME | Chicago | P820 Human Services | $130.9M | 7 |
| SAINT XAVIER UNIVERSITY | Chicago | B430 Education | $130.4M | 11 |
| Roosevelt University | Chicago | — | $130.4M | 19 |
| Insight Chicago Inc | Chicago | E22 Health Care | $129.6M | 9 |
| CHICAGO CHARTER SCHOOL FOUNDATION | Chicago | B20 Education | $129.6M | 11 |
| UNLIMITED DEVELOPMENT INC | Galesburg | L22 Housing & Shelter | $128.5M | 9 |
| MCGAW MEDICAL CENTER OF NORTHWESTERN UNIVERSITY | Chicago | — | $128.1M | 0 |
| HOSPITAL & MEDICAL FOUNDATION OF PARIS INC | Paris | E21Z Health Care | $128M | 9 |
| ADVENTIST GLENOAKS HOSPITAL | Glendale Heights | — | $126.9M | 10 |
| RELIGIOUS AND CHARITABLE RISK POOLING TRUST OF THE BROTHERS OF THE CHRISTIAN | Romeoville | X20 Religion-Related | $125.8M | 0 |
| AUTOMOBILE MECHANICS' LOCAL NO 701 UNION AND INDUSTRY WELFARE | Burr Ridge | — | $125.6M | 3 |
| Chicago Symphony Orchestra | Chicago | A690 Arts, Culture & Humanities | $125.5M | 10 |
| ACERO CHARTER SCHOOLS INC | Chicago | — | $124.9M | 10 |
| DOMINICAN UNIVERSITY | River Forest | B430 Education | $124M | 15 |
| St Mary's Hospital Decatur of the Hospital Sisters of the Third Order of St Francis | Decatur | E220 Health Care | $123.2M | 11 |
| St Bernard Hospital | Chicago | E220 Health Care | $122.7M | 11 |
| Erie Family Health Center Inc | Chicago | E320 Health Care | $122.2M | 12 |
| SCOTT CREDIT UNION | Edwardsville | — | $121M | 13 |
| THE THRESHOLDS | Chicago | — | $120.6M | 17 |
| The Moody Bible Institute of Chicago | Chicago | B500 Education | $119.3M | 21 |
| American Bar Association | Chicago | — | $119.1M | 19 |
| SINAI HEALTH SYSTEM | Chicago | E112 Health Care | $118.9M | 15 |
