| PRESBYTERIAN HOMES | Skokie | P99 Human Services | $111.8M | 12 |
| The Negaunee Foundation | Northbrook | — | $111.5M | 0 |
| ROTARY INTERNATIONAL | Evanston | — | $111.2M | 18 |
| Rush System for Health | Chicago | E99Z Health Care | $110M | 8 |
| THE THRESHOLDS | Chicago | — | $109.8M | 17 |
| Gateway Foundation Inc | Chicago | F220 Mental Health & Crisis Intervention | $109.5M | 14 |
| UNITED AIRLINES PILOT DISABILITY VEBA | Chicago | Y43 Mutual & Membership Benefit | $109M | 0 |
| Chicago Zoological Society | Brookfield | D500 Animal-Related | $108M | 12 |
| American Bar Association | Chicago | — | $108M | 17 |
| AMERICAN LUNG ASSOCIATION | Chicago | G450 Diseases, Disorders & Medical Disciplines | $107.7M | 14 |
| LUTHERAN SOCIAL SERVICES OF ILLINOIS | Des Plaines | — | $107.4M | 7 |
| MID-AMERICA CARPENTERS REGIONAL COUNCIL | Chicago | — | $106.6M | 27 |
| Ronald McDonald House Charities Inc | Chicago | E860 Health Care | $106.3M | 0 |
| INFORMATION SYSTEMS AUDIT AND CONTROL ASSOCIATION INC | Schaumburg | — | $104.8M | 12 |
| Special Education Services | North Aurora | B280 Education | $104.8M | 12 |
| MOUNT SINAI COMMUNITY FOUNDATION | Chicago | — | $101.3M | 13 |
| International Code Council Inc | Country Club Hills | S41 Community Improvement & Capacity Building | $100.1M | 20 |
| National YMCA Employee Benefits Trust | Chicago | — | $99.3M | 1 |
| JACKSON PARK HOSPITAL FOUNDATION | Chicago | E220 Health Care | $99M | 20 |
| CREDIT UNION 1 | Rantoul | — | $98.1M | 13 |
| ROBERT R MCCORMICK FOUNDATION | Chicago | T99Z Philanthropy, Voluntarism & Grantmaking Foundations | $97.6M | 16 |
| La Rabida Children's Hospital | Chicago | E240 Health Care | $96.6M | 17 |
| SOUTHEASTERN ILLINOIS ELECTRIC COOP INC | Carrier Mills | — | $96.1M | 24 |
| Caterpillar Foundation | Peoria | — | $96M | 0 |
| TRINITY SERVICES INC | New Lenox | P46 Human Services | $95.3M | 10 |
| UNION HEALTH SERVICE INC | Chicago | E800 Health Care | $95.1M | 11 |
| CONCORDIA UNIVERSITY | River Forest | B430 Education | $94.8M | 11 |
| MILLIKIN UNIVERSITY | Decatur | B420 Education | $94.5M | 12 |
| SHEDD AQUARIUM SOCIETY | Chicago | D500 Animal-Related | $93M | 13 |
| WASHINGTON UNIVERSITY PHYSICIANS IN ILLINOIS INC | O'Fallon | E20 Health Care | $92.7M | 3 |
| EVANS SCHOLARS FOUNDATION | Glenview | B820 Education | $92.7M | 9 |
| RESIDENTIAL ALTERNATIVES OF ILLINOIS INC | Galesburg | P73Z Human Services | $92.5M | 10 |
| SOUTHERN ILLINOIS HEALTHCARE FOUNDATION | Sauget | E320 Health Care | $92.3M | 17 |
| Elmhurst Memorial Healthcare | Elmhurst | E220 Health Care | $91.9M | 0 |
| North Park University | Chicago | B430 Education | $91.8M | 10 |
| TEAMSTERS LOCAL 727 HEALTH AND WELFARE | Park Ridge | — | $89.9M | 13 |
| LOCAL 1 HEALTH FUND | Downers Grove | — | $89.5M | 6 |
| PLUMBERS WELFARE FUND LOCAL 130 UA | Chicago | — | $89.1M | 9 |
| SINAI HEALTH SYSTEM | Chicago | E112 Health Care | $89.1M | 15 |
| Benedictine University | Lisle | B430 Education | $88.5M | 10 |
| EHS HOME HEALTH CARE SERVICE INC | Oak Brook | E920 Health Care | $88.4M | 36 |
| TOUCHETTE REGIONAL HOSPITAL | Cahokia Heights | E220 Health Care | $88.4M | 12 |
| Corn Belt Energy Corporation | Bloomington | — | $88.3M | 20 |
| NATIONAL ASSOCIATION FOR THE EXCHANGE OF | Galesburg | S030 Community Improvement & Capacity Building | $87.2M | 3 |
| NATIONAL EQUITY FUND INC | Chicago | — | $86M | 25 |
| KNOX COLLEGE | Galesburg | B420 Education | $85.7M | 15 |
| MILLION DOLLAR ROUND TABLE | Park Ridge | — | $85.3M | 12 |
| LAWNDALE CHRISTIAN HEALTH CENTER | Chicago | — | $85.1M | 13 |
| Big Shoulders Fund | Chicago | B122 Education | $84.8M | 9 |
| ACCREDITATION COUNCIL FOR GRADUATE | Chicago | B50 Education | $84.7M | 7 |
