| The Rogosin Institute Inc | New York | E050 Health Care | $118.4M | 31 |
| NYSARC INC FULTON-SCHOHARIE COUNTIES CHAPTER | Johnstown | P820 Human Services | $118.1M | 8 |
| ACCESS SUPPORTS FOR LIVING INC | Middletown | P820 Human Services | $118.1M | 16 |
| CAYUGA MEDICAL ASSOCIATES PC | Ithaca | E20 Health Care | $117.9M | 14 |
| Overdeck Family Foundation Inc | New York | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $117.9M | 2 |
| NEW YORK MEDICAL COLLEGE | Valhalla | — | $117.9M | 15 |
| THE BREAST CANCER RESEARCH FOUNDATION INC | New York | M20Z Public Safety, Disaster Preparedness & Relief | $117.4M | 12 |
| CENTER FOR DISABILITY SERVICESINC | Albany | G200 Diseases, Disorders & Medical Disciplines | $117.3M | 8 |
| WAGNER COLLEGE | Staten Island | B430 Education | $117M | 12 |
| NEW YORK ROAD RUNNERS INC C/O FINANCE DEPARTMENT | New York | — | $116.7M | 9 |
| PROJECT RENEWAL INC | New York | F300 Mental Health & Crisis Intervention | $116.5M | 11 |
| THE PAUL E SINGER FOUNDATION | New York | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $115.9M | 2 |
| AIM SERVICES INC | Saratoga Springs | P73Z Human Services | $115.8M | 9 |
| AMERICAN SOCIETY FOR TECHNION ISRAEL INSTITUTE OF TECHNOLOGY INC | New York | Q300 International, Foreign Affairs & National Security | $115.8M | 12 |
| GIRL SCOUTS OF THE UNITED STATES OF AMERICA | New York | O420 Youth Development | $115.6M | 12 |
| ROME MEMORIAL HOSPITAL | Rome | E22Z Health Care | $115.1M | 6 |
| ALICE HYDE MEDICAL CENTER | Malone | E220 Health Care | $114.5M | 14 |
| PRACTISING LAW INSTITUTE | New York | B600 Education | $114.3M | 14 |
| THE YOUNG MEN'S AND YOUNG WOMEN'S HEBREW ASSOCIATION | New York | X110 Religion-Related | $114M | 16 |
| THE PHILHARMONIC SYMPHONY SOCIETY OF NY INC | New York | A690 Arts, Culture & Humanities | $113.9M | 9 |
| BRONXWORKS INC | Bronx | P200 Human Services | $113.5M | 9 |
| GUTHRIE CORTLAND MEDICAL CENTER FKA CORTLAND REGIONAL MEDICAL CENTER | Cortland | E220 Health Care | $113.4M | 14 |
| TED FOUNDATION INC | New York | S19 Community Improvement & Capacity Building | $113.2M | 2 |
| ADULTS AND CHILDREN WITH LEARNING AND DEVELOPMENTAL DISABILITIES INC | Bethpage | P820 Human Services | $113.1M | 9 |
| ONE BROOKLYN HEALTH SYSTEM INC | Brooklyn | E21 Health Care | $112.7M | 5 |
| UPSTATE CEREBRAL PALSY INC | Utica | G200 Diseases, Disorders & Medical Disciplines | $112.4M | 8 |
| CATHOLIC HEALTH CARE SYSTEM | New York | — | $112.3M | 9 |
| IRON WORKERS LOCALS 40 361 & 417 HEALTH FUND | New York | — | $112.1M | 5 |
| BLYTHEDALE CHILDREN'S HOSPITAL | Valhalla | E24 Health Care | $112M | 15 |
| COMMUNITY HOUSING INNOVATIONS INC | White Plains | — | $111.6M | 8 |
| TERENCE CARDINAL COOKE HEALTH CARE CENTER | New York | E910 Health Care | $111.5M | 8 |
| CHENANGO MEMORIAL HOSPITAL INC | Norwich | E220 Health Care | $111.5M | 15 |
| ODA PRIMARY HEALTH CARE NETWORK INC | Brooklyn | — | $111.5M | 9 |
| ELECTRICAL INDUSTRY BOARD OF NASSAU AND SUFFOLK COUNTIES NEW YORK | Hauppauge | — | $111.3M | 1 |
| THE BRONX PARENT HOUSING NETWORK INC | Bronx | P80 Human Services | $111.2M | 9 |
| Bat Hanadiv Foundation No 3 | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $111.1M | 1 |
| WNET | New York | A32 Arts, Culture & Humanities | $111.1M | 15 |
| DALTON SCHOOLS INC | New York | B200 Education | $110.8M | 12 |
| NEW YORK BOTANICAL GARDEN | Bronx | C410 Environment | $110.4M | 12 |
| AMDA INC (AMERICAN MUSICAL AND DRAMATIC ACADEMY) | New York | — | $110.1M | 9 |
| COMMUNITY HEALTH PROJECT INC | New York | E32Z Health Care | $110M | 11 |
| PARKER JEWISH INSTITUTE FOR HEALTH CARE AND REHABILITATION | New Hyde Park | E910 Health Care | $109.2M | 10 |
| Central Fund of Israel | Cedarhurst | Q123 International, Foreign Affairs & National Security | $109.2M | 1 |
| LIFETIME ASSISTANCE INC | Rochester | P820 Human Services | $108.9M | 9 |
| ADVANCE CARE ALLIANCE OF NY INC | Hauppauge | P82 Human Services | $108.8M | 8 |
| MOUNT SINAI HEALTH SYSTEM SELF INSURANCE TRUST | New York | E30 Health Care | $108.6M | 1 |
| GENEVA GENERAL HOSPITAL | Geneva | E220 Health Care | $108.5M | 18 |
| THE LONG ISLAND HOME C/O NORTHWELL HEALTH INC | Westbury | F310 Mental Health & Crisis Intervention | $107.8M | 20 |
| GOODWILL INDUSTRIES OF GREATER NEW YORK & NORTHERN NEW JERSEY INC | Brooklyn | J320 Employment | $106.3M | 8 |
| ITHAKA HARBORS INC | New York | V30 Social Science | $106M | 27 |
