| IRON WORKERS LOCALS 40 361 & 417 HEALTH FUND | New York | — | $112.4M | 6 |
| CATHOLIC HEALTH CARE SYSTEM | New York | — | $112.3M | 9 |
| URBAN RESOURCE INSTITUTE | New York | P200 Human Services | $112M | 8 |
| CLNY ALLIANCE INC | Westbury | E19 Health Care | $111.9M | 11 |
| Jader Trust 4 | New York | — | $111.7M | 1 |
| COMMUNITY HOUSING INNOVATIONS INC | White Plains | — | $111.6M | 8 |
| ADVANCE CARE ALLIANCE OF NY INC | Hauppauge | P82 Human Services | $111.6M | 12 |
| CHENANGO MEMORIAL HOSPITAL INC | Norwich | E220 Health Care | $111.5M | 15 |
| Montefiore Mount Vernon Hospital | Mount Vernon | E20 Health Care | $111.5M | 10 |
| ODA PRIMARY HEALTH CARE NETWORK INC | Brooklyn | — | $111.5M | 9 |
| ELECTRICAL INDUSTRY BOARD OF NASSAU AND SUFFOLK COUNTIES NEW YORK | Hauppauge | — | $111.3M | 1 |
| UB FOUNDATION ACTIVITIES INC | Buffalo | — | $111.2M | 5 |
| HASC CENTER INC | Brooklyn | P820 Human Services | $111.2M | 9 |
| Bat Hanadiv Foundation No 3 | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $111.1M | 1 |
| PHIPPS HOUSES | New York | L20 Housing & Shelter | $110.9M | 12 |
| THE NEW YORK CLIMATE EXCHANGE INC | New York | C05 Environment | $110.7M | 1 |
| The Frick Collection | New York | — | $110.4M | 13 |
| PARKER JEWISH INSTITUTE FOR HEALTH CARE AND REHABILITATION | New Hyde Park | E910 Health Care | $109.2M | 10 |
| NEW YORK BOTANICAL GARDEN | Bronx | C410 Environment | $109.1M | 12 |
| LIFETIME ASSISTANCE INC | Rochester | P820 Human Services | $108.9M | 9 |
| MOUNT SINAI HEALTH SYSTEM SELF INSURANCE TRUST | New York | E30 Health Care | $108.6M | 1 |
| GENEVA GENERAL HOSPITAL | Geneva | E220 Health Care | $108.5M | 18 |
| THE LONG ISLAND HOME C/O NORTHWELL HEALTH INC | Westbury | F310 Mental Health & Crisis Intervention | $107.8M | 20 |
| GOODWILL INDUSTRIES OF GREATER NEW YORK & NORTHERN NEW JERSEY INC | Brooklyn | J320 Employment | $107.5M | 11 |
| DALTON SCHOOLS INC | New York | B200 Education | $107.4M | 13 |
| LAWRENCE MEDICAL ASSOCIATES PC | Bronxville | E30 Health Care | $106.7M | 8 |
| HOME LIFE SERVICES INC | Brooklyn | L41 Housing & Shelter | $106.4M | 13 |
| FEDCAP REHABILITATION SERVICES INC | New York | — | $106M | 9 |
| ISLAND PEER REVIEW ORGANIZATION INC | New Hyde Park | W200 Public & Societal Benefit | $105.6M | 30 |
| BNA Prefunded VEBA Trust | Brooklyn | — | $105.5M | 1 |
| LONG ISLAND JEWISH MEDICAL CENTER AT HOME PHARMACY | Westbury | E99Z Health Care | $105.5M | 15 |
| SPORTS PHYSICAL THERAPY OCCUPATIONAL THERAPY AND REHAB SERVICES OF NORTH SHORE PLLC | Westbury | E50 Health Care | $105M | 12 |
| The Hebrew Home for Aged at Riverdale | Bronx | E90 Health Care | $104.9M | 8 |
| THE WESTCHESTER MEDICAL PRACTICE PC | Yorktown Heights | E60 Health Care | $104.5M | 7 |
| NURSING SISTERS HOME CARE INC | Farmingdale | E92Z Health Care | $104.3M | 7 |
| CANISIUS UNIVERSITY | Buffalo | B430 Education | $103.8M | 14 |
| QSAC INC | New York | G84Z Diseases, Disorders & Medical Disciplines | $103.6M | 8 |
| Puerto Rican Organization to Motivate Enlighten and Serve Addicts Inc | Bronx | F220 Mental Health & Crisis Intervention | $103.4M | 11 |
| LIFESPIRE INC | New York | P820 Human Services | $102.7M | 8 |
| CHILDREN'S RESCUE FUND | Bronx | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $101.9M | 9 |
| DORIS DUKE CHARITABLE FOUNDATION INC | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $101.7M | 7 |
| CATHOLIC CHARITIES OF THE DIOCESE OF ROCHESTER | Rochester | — | $101.5M | 7 |
| NDC HOUSING & ECONOMIC DEVELOPMENT CORPORATION - GROUP RETURN | New York | L200 Housing & Shelter | $101.5M | 11 |
| VISITING NURSING ASSOCIATION OF WESTERN NEW YORK INC | Cheektowaga | E92 Health Care | $100.8M | 9 |
| HELIO HEALTH INC | Syracuse | F220 Mental Health & Crisis Intervention | $100.8M | 8 |
| MOUNT SINAI HEALTH SYSTEM INC | New York | P20 Human Services | $100.3M | 10 |
| University Associates in Obstetrics and Gynecology University Faculty Practice Corporation | Stony Brook | E20 Health Care | $100.1M | 9 |
| PEPSICO FOUNDATION INC | Purchase | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $100M | 0 |
| ISABELLA GERIATRIC CENTER INC | New York | P750 Human Services | $99.9M | 9 |
| D'YOUVILLE UNIVERSITY | Buffalo | B430 Education | $99.7M | 6 |
