| HAO FAMILY FOUNDATION | Saratoga Springs | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $62.2M | 0 |
| ST JAMES HOSPITAL | Hornell | E220 Health Care | $62M | 11 |
| WILDWOOD PROGRAMS INC | Latham | Z99 Unknown | $61.9M | 2 |
| HISPANIC FEDERATION INC | New York | S50Z Community Improvement & Capacity Building | $61.8M | 9 |
| ALBANY COLLEGE OF PHARMACY | Albany | B500 Education | $61.8M | 8 |
| SECURITIES INDUSTRY AND FINANCIAL | New York | S40 Community Improvement & Capacity Building | $61.8M | 13 |
| Montefiore Mount Vernon Hospital | Mount Vernon | E20 Health Care | $61.7M | 10 |
| COMMUNITY MEMORIAL HOSPITAL INC | Hamilton | E220 Health Care | $61.6M | 9 |
| THE JEWISH ASSOCIATION FOR SERVICES | New York | P810 Human Services | $61.6M | 0 |
| TRILLIUM HEALTH INC | Rochester | — | $61.4M | 9 |
| AMNESTY INTERNATIONAL OF THE USA INC | New York | Q700 International, Foreign Affairs & National Security | $61.2M | 13 |
| NEW YORK SHAKESPEARE FESTIVAL | New York | A650 Arts, Culture & Humanities | $61.1M | 13 |
| WESTERN NEW YORK INDEPENDENT | Buffalo | E99Z Health Care | $61.1M | 3 |
| INDEPENDENT LIVING ASSOCIATION | Brooklyn | P700 Human Services | $61M | 8 |
| LYCEE FRANCAIS DE NEW YORK | New York | B200 Education | $61M | 7 |
| EVERYTOWN FOR GUN SAFETY ACTION FUND | New York | I192 Crime & Legal-Related | $60.7M | 6 |
| THE VIVIAN BEAUMONT THEATERINC | New York | A650 Arts, Culture & Humanities | $60.6M | 15 |
| SHED NYC INC | New York | A20 Arts, Culture & Humanities | $60.6M | 19 |
| GLOBAL POVERTY PROJECT INC | New York | V30 Social Science | $60.6M | 12 |
| Harmony Health Care Long Island | Garden City | E30 Health Care | $60.5M | 11 |
| BROOKLYN PROSPECT CHARTER SCHOOL | Brooklyn | B29 Education | $60.5M | 5 |
| NEW YORK LIFE INSURANCE COMPANY | New York | — | $60.4M | 0 |
| ROCKEFELLER FAMILY FUND INC | New York | T900 Philanthropy, Voluntarism & Grantmaking Foundations | $60.4M | 7 |
| CUBRC INC | Buffalo | U32Z Science & Technology | $60.3M | 18 |
| GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT INC | New York | H80 Medical Research | $60.2M | 12 |
| WELFARE FUND OF LOCAL NO ONE IATSE | New York | — | $60.2M | 3 |
| PREMIUM HEALTH INC | Brooklyn | E32 Health Care | $60.2M | 15 |
| TEAMSTERS LOCAL 210 AFFILIATED HEALTH & | Staten Island | Y44 Mutual & Membership Benefit | $60.1M | 0 |
| Little Falls Hospital | Little Falls | E220 Health Care | $60.1M | 13 |
| FAMILY SERVICE LEAGUE INC | Huntington | P400 Human Services | $59.9M | 16 |
| PARSONS CHILD AND FAMILY CENTER | Albany | P300 Human Services | $59.9M | 7 |
| GRAHAM WINDHAM | Brooklyn | P200 Human Services | $59.5M | 10 |
| VOLUNTARY HOSPITALS HOUSE STAFF | Long Island City | Y43 Mutual & Membership Benefit | $59.4M | 0 |
| BRONX CHARTER SCHOOL FOR EXCELLENCE | Bronx | B29 Education | $59.1M | 11 |
| NEIGHBORHOOD HEALTH CENTER OF WNY INC | Buffalo | — | $59.1M | 7 |
| JOINT INDUSTRY BOARD OF THE ELECTRICAL INDUSTRY | Flushing | — | $59M | 9 |
| MASSENA HOSPITAL INC | Massena | E22 Health Care | $59M | 13 |
| FJC | New York | I990 Crime & Legal-Related | $58.9M | 6 |
| CENTER FOR ALTERNATIVE SENTENCING AND | Brooklyn | — | $58.9M | 13 |
| CDS MONARCH INC | Webster | P73Z Human Services | $58.8M | 9 |
| THE BRONX DEFENDERS | Bronx | I80 Crime & Legal-Related | $58.8M | 30 |
| The Pierpont Morgan Library | New York | B700 Education | $58.7M | 8 |
| RETHINK FOOD NYC INC | New York | K30 Food, Agriculture & Nutrition | $58.7M | 11 |
| COBBLE HILL HEALTH CENTER INC | Brooklyn | E91Z Health Care | $58.6M | 8 |
| LAMBDA LEGAL DEFENSE & EDUCATION FUND | New York | R20Z Civil Rights, Social Action & Advocacy | $58.5M | 14 |
| INTERNATIONAL COUNCIL OF SHOPPING | New York | — | $58.4M | 8 |
| THE FRIENDS OF CROWN HEIGHTS | Brooklyn | P330 Human Services | $58.3M | 8 |
| THE SPENCE SCHOOL | New York | B200 Education | $58.1M | 12 |
| CITIZEN ADVOCATES INC | Malone | P800 Human Services | $58M | 10 |
| PRO PUBLICA INC | New York | A20 Arts, Culture & Humanities | $58M | 11 |
