| Youth Guidance | Chicago | B80 Education | $49.5M | 11 |
| KIPP CHICAGO SCHOOLS | Chicago | B29 Education | $48.9M | 7 |
| WESTERN CATHOLIC UNION | Quincy | — | $48.8M | 12 |
| Harrisburg Medical Center Inc | Harrisburg | E220 Health Care | $48.6M | 18 |
| MATHER INVESTMENTS NFP | Evanston | P81 Human Services | $48.4M | 10 |
| UNITED WAY OF METROPOLITAN CHICAGO INC | Chicago | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $48.3M | 10 |
| Adler University | Chicago | B5XZ Education | $48.1M | 17 |
| OPPORTUNITY INTERNATIONAL INC | Chicago | Q320 International, Foreign Affairs & National Security | $47.8M | 9 |
| BENEVOLENT AND PROTECTIVE ORDER OF ELKS | Chicago | — | $47.7M | 6 |
| VIBRANT CREDIT UNION | Moline | W61 Public & Societal Benefit | $47.3M | 9 |
| South Shore Hospital Corporation | Chicago | E220 Health Care | $46.8M | 8 |
| PLYMOUTH PLACE INC | LaGrange Park | P750 Human Services | $46.7M | 8 |
| Egyptian Electric Cooperative Association | Murphysboro | — | $46.7M | 16 |
| LITTLE CITY FOUNDATION | Inverness | P700 Human Services | $46.7M | 7 |
| AMERICAN ACADEMY OF DERMATOLOGY INC | Rosemont | G90 Diseases, Disorders & Medical Disciplines | $46.7M | 31 |
| CORPORATE AMERICA FAMILY CREDIT UNION | Elgin | — | $46.5M | 11 |
| AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS | Rosemont | G030 Diseases, Disorders & Medical Disciplines | $46.5M | 32 |
| FOX VALLEY LABORERS HEALTH & WELFARE FND | Elgin | — | $46.3M | 4 |
| NATIONAL SAFETY COUNCIL | Itasca | M400 Public Safety, Disaster Preparedness & Relief | $46.2M | 19 |
| GREATER FAMILY HEALTH | Hoffman Estates | E99 Health Care | $46.1M | 11 |
| PANA COMMUNITY HOSPITAL ASSOCIATION | Pana | E22 Health Care | $45.8M | 10 |
| Jewish Community Centers of Chicago | Northbrook | P280 Human Services | $45.6M | 10 |
| Polish National Alliance of the US of NA | Chicago | — | $45.6M | 10 |
| Maryville Academy | Des Plaines | P730 Human Services | $45.6M | 8 |
| The Resurrection Project | Chicago | L20Z Housing & Shelter | $45.5M | 9 |
| CIRCLE OF SERVICE FOUNDATION | Chicago | — | $45.5M | 1 |
| IROQUOIS MEMORIAL HOSPITAL | Watseka | E22Z Health Care | $45.5M | 9 |
| THE CHICAGO LIGHTHOUSE FOR PEOPLE WHO | Chicago | P86 Human Services | $45.4M | 8 |
| GOODWILL INDUSTRIES OF NORTHERN IL AND | Rockford | — | $45.3M | 5 |
| COVENANT LIVING COMMUNITIES AND SERVICES | Skokie | P750 Human Services | $45.3M | 16 |
| THE MORTON ARBORETUM | Lisle | C410 Environment | $45.1M | 13 |
| NAVISTAR INC RETIREE HEALTH BENEFIT | Lisle | — | $45.1M | 1 |
| CHRISTIAN SOCIAL SERVICES OF ILLINOIS | Belleville | P20 Human Services | $44.9M | 8 |
| THE CENTER FOR YOUTH AND FAMILY | Peoria | P32 Human Services | $44.9M | 11 |
| THE MEMBERS RETIREMENT PLAN | St Charles | — | $44.8M | 2 |
| NATIONAL ASSOCIATION OF BOARDS OF | Mount Prospect | — | $44.6M | 14 |
| TRUSTEES OF LIQUOR & ALLIED WORKER | River Forest | — | $44.5M | 2 |
| MIDWEST MEDICAL CENTER | Galena | E11 Health Care | $44.4M | 7 |
| ILLINOIS ELECTRIC COOPERATIVE | Winchester | — | $44.3M | 18 |
| OPERATING ENGINEERS LOCAL 150 | Countryside | J220 Employment | $44.3M | 6 |
| UNIVERSITY OF ILLINOIS COMMUNITY CREDIT | Champaign | — | $44.3M | 18 |
| INTERNATIONAL BROTHERHOOD OF TEAMSTERS | Mokena | — | $44.2M | 8 |
| Caerus Foundation Inc | Northbrook | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $44.2M | 0 |
| MATHER FOUNDATION | Evanston | E19 Health Care | $44.2M | 5 |
| FREEPORT REGIONAL HEALTH CARE FOUNDATION | Freeport | E110 Health Care | $44.1M | 14 |
| ROCKFORD UNIVERSITY | Rockford | B430 Education | $43.7M | 8 |
| Good News Publishers | Wheaton | — | $43.6M | 21 |
| THE HOPEDALE MEDICAL FOUNDATION | Hopedale | E22I Health Care | $43.4M | 10 |
| IPC INTERNATIONAL INC | Bannockburn | — | $43.3M | 12 |
| RESTORATION OF AMERICA | Downers Grove | R11 Civil Rights, Social Action & Advocacy | $43.3M | 13 |
