| JEANNE D'ARC CREDIT UNION | Lowell | — | $106.2M | 19 |
| SERVICENET INC | Northampton | F330 Mental Health & Crisis Intervention | $105.6M | 8 |
| Physicians Organization at Children's Hospital Inc | Boston | E83Z Health Care | $104.9M | 31 |
| GREATER LAWRENCE FAMILY HEALTH CENTER INC | Methuen | E320 Health Care | $104.5M | 14 |
| TRUSTEES OF DEERFIELD ACADEMY | Deerfield | B250 Education | $103.4M | 9 |
| BROOKSBY VILLAGE INC | Peabody | L22 Housing & Shelter | $103.2M | 8 |
| UNIVERSITY OF MASSACHUSETTS FOUNDATION INC | Newton | B110 Education | $102.2M | 10 |
| BAYSTATE WING HOSPITAL CORPORATION | Palmer | E22 Health Care | $101.6M | 16 |
| LYNN COMMUNITY HEALTH INC | Lynn | — | $100.4M | 12 |
| CENTRAL BOSTON ELDER SERVICES INC | Boston | P81Z Human Services | $100.2M | 5 |
| REGIS COLLEGE | Weston | B420 Education | $99.7M | 7 |
| THE COMMUNITY BUILDERS INC | Boston | L210 Housing & Shelter | $99.7M | 11 |
| New England Organ Bank Inc | Waltham | — | $99.4M | 2 |
| FAIRVIEW HOSPITAL | Pittsfield | E22Z Health Care | $97.4M | 14 |
| JOHN HANCOCK LIFE INS CO EMPLOYEE WELFARE TRUST | Boston | Y43 Mutual & Membership Benefit | $95.4M | 0 |
| Franciscan Hospital for Children | Brighton | E24 Health Care | $94.8M | 14 |
| MILTON ACADEMY | Milton | B200 Education | $94.5M | 10 |
| HIGH POINT TREATMENT CENTER INC | New Bedford | F32 Mental Health & Crisis Intervention | $94.3M | 7 |
| JOBS FOR THE FUTURE INC | Boston | J20E Employment | $93.8M | 12 |
| MAKING OPPORTUNITY COUNT INC | Fitchburg | P200 Human Services | $93.1M | 7 |
| BOSTON HEALTH CARE FOR THE HOMELESS PROGRAM INC | Boston | P20 Human Services | $92.5M | 11 |
| THE BRIDGESPAN GROUP INC | Boston | S50 Community Improvement & Capacity Building | $91.6M | 17 |
| MERRIMACK VALLEY CREDIT UNION | Lawrence | — | $91.4M | 44 |
| Children's Orthopaedic Surgery FoundationInc | Boston | E122 Health Care | $89.6M | 37 |
| OLD COLONY YOUNG MEN'S CHRISTIAN ASSOCIATION INC | Brockton | P270 Human Services | $89M | 12 |
| MOUNT AUBURN PROFESSIONAL SERVICES INC | Charlestown | E22C Health Care | $89M | 18 |
| THE HOME FOR LITTLE WANDERERS INC | Boston | P300 Human Services | $88.9M | 13 |
| ADELSON FAMILY FOUNDATION | Needham | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $88M | 0 |
| BRIDGEWELL INC | Peabody | — | $87.5M | 9 |
| SOUTH SHORE MEDICAL CENTER INC | Norwell | E300 Health Care | $86.2M | 13 |
| COMMONWEALTH CLINICAL ALLIANCE INC | Boston | E31 Health Care | $85.7M | 5 |
| COMMUNITY RESOURCES FOR JUSTICE INC | Boston | I40 Crime & Legal-Related | $84.8M | 16 |
| BROCKTON NEIGHBORHOOD HEALTH CENTER INC | Brockton | — | $84.2M | 10 |
| EDWARD C JOHNSON FUND | Boston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $84.1M | 3 |
| IUOE LOCAL 4 HEALTH & WELFARE PLAN | Medway | — | $83.9M | 5 |
| Boston Children's Heart Foundation Inc | Boston | E122 Health Care | $83.8M | 22 |
| BAYSTATE NOBLE HOSPITAL CORPORATION | Westfield | E220 Health Care | $83M | 19 |
| STURDY HEALTH INC | Attleboro | — | $82.5M | 10 |
| MASSACHUSETTS LEGAL ASSISTANCE CORP | Boston | I80Z Crime & Legal-Related | $82.3M | 8 |
| American International College | Springfield | B430 Education | $82.3M | 8 |
| HEALTH RESOURCES IN ACTION INC | Boston | — | $82.1M | 9 |
| PAN-MASSACHUSETTS CHALLENGE INC | Needham | — | $81.8M | 7 |
| THE AMERICAN COLLEGE OF GREECE | Boston | Q300 International, Foreign Affairs & National Security | $81.7M | 7 |
| LASELL UNIVERSITY | Newton | B420 Education | $81M | 10 |
| NEW ENGLAND CONSERVATORY OF MUSIC | Boston | B430 Education | $80.2M | 10 |
| PERKINS SCHOOL FOR THE BLIND | Watertown | B280 Education | $79.8M | 11 |
| LINDEN PONDS INC | Hingham | L22 Housing & Shelter | $79.1M | 8 |
| GANDARA MENTAL HEALTH CENTER INC | Springfield | — | $79M | 5 |
| NORTHEAST BEHAVIORAL HEALTH CORPORATION | Charlestown | F300 Mental Health & Crisis Intervention | $79M | 17 |
| COMMUNITY COUNSELING OF BRISTOL COUNTY INC | Taunton | F32Z Mental Health & Crisis Intervention | $78.6M | 8 |
