| ODYSSEY HOUSE INC | New York | F220 Mental Health & Crisis Intervention | $46M | 8 |
| The Sundheim Family Foundation | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $45.8M | 0 |
| ABILITIES FIRST INC | Wappingers Falls | J33Z Employment | $45.8M | 9 |
| PSC-CUNY WELFARE FUND | New York | — | $45.8M | 8 |
| FULLER ROAD MANAGEMENT CORPORATION | Albany | — | $45.8M | 9 |
| HORIZON HEALTH SERVICES INC | Getzville | F20Z Mental Health & Crisis Intervention | $45.8M | 7 |
| PATHSTONE CORPORATION | Rochester | S32Z Community Improvement & Capacity Building | $45.7M | 7 |
| WEIZMANN CHAIRS AND SCHOLARSHIPS ENDOWMENT INC | New York | B11 Education | $45.6M | 1 |
| THE YALE CLUB OF NEW YORK CITY | New York | — | $45.6M | 6 |
| CENTER FOR DEVELOPMENTAL DISABILITIES | Woodbury | P820 Human Services | $45.6M | 10 |
| FAMILY LIFE ACADEMY CHARTER SCHOOLS | Bronx | B29 Education | $45.5M | 15 |
| HAMASPIK OF ORANGE COUNTY INC | Monroe | — | $45.4M | 7 |
| FALLON HEALTH WEINBERG INC | Getzville | P75 Human Services | $45.4M | 11 |
| INTERNATIONAL FEDERATION OF ACCOUNTANTS | New York | B50P Education | $45.4M | 19 |
| NYSARC INC ROCKLAND COUNTY CHAPTER | Valley Cottage | P820 Human Services | $45.4M | 8 |
| LOCAL 338 RWDSUUFCW HEALTH & WELFARE FUND | Mineola | — | $45.4M | 10 |
| CRISIS TEXT LINE INC | New York | F40 Mental Health & Crisis Intervention | $45.4M | 9 |
| CHILDREN'S HOME OF WYOMING CONFERENCE | Binghamton | P700 Human Services | $45.3M | 7 |
| WOMEN'S LEAGUE COMMUNITY RESIDENCES | Brooklyn | — | $45.3M | 8 |
| Helen Keller Services | Brooklyn | P860 Human Services | $45.3M | 9 |
| JEWISH HOME LIFECARE SARAH NEUMAN CENTER WESTCHESTER | New York | E910 Health Care | $45.2M | 8 |
| LOCAL 295 IBT EMPLOYER GROUP WELFARE FUND | New York | — | $45.2M | 3 |
| NYSARC INC ONEIDA-LEWIS CHAPTER | Utica | — | $45.2M | 3 |
| SUNNYSIDE HOME CARE PROJECT INC | Long Island City | E920 Health Care | $45.1M | 3 |
| ESL CHARITABLE FOUNDATION | Rochester | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $45.1M | 0 |
| NORTH SHORE ANIMAL LEAGUE AMERICA INC | Port Washington | D200 Animal-Related | $45.1M | 11 |
| HOTEL AND GAMING TRADES COUNCIL AFL-CIO | New York | J40 Employment | $45M | 25 |
| SCOPE EDUCATION SERVICES | Smithtown | B00A Education | $44.9M | 6 |
| FIT STUDENT HOUSING CORPORATION | New York | — | $44.9M | 4 |
| BIKUR CHOLIM INC | Airmont | E86Z Health Care | $44.9M | 7 |
| National Health Care Inc and Affiliate Voluntary Employee Benefit Assoc Plan | Valley Stream | — | $44.9M | 0 |
| CHAPEL & YORK US FOUNDATION INC | New York | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $44.8M | 0 |
| THE POSSE FOUNDATION INC | New York | B82 Education | $44.8M | 9 |
| THE MARK FOUNDATION FOR CANCER RESEARCH (US) LTD | New York | G30 Diseases, Disorders & Medical Disciplines | $44.8M | 10 |
| EDEN II SCHOOL FOR AUTISTIC CHILDREN | Staten Island | B280 Education | $44.8M | 7 |
| THE JEFF SUTTON CHARITABLE FOUNDATION | New York | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $44.7M | 0 |
| AMERICAN FOUNDATION FOR SUICIDE PREVENTION | New York | F110 Mental Health & Crisis Intervention | $44.7M | 12 |
| PETER G PETERSON FOUNDATION | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $44.6M | 6 |
| THE FUND FOR PUBLIC SCHOOLS INC | New York | — | $44.6M | 4 |
| CARSON FAMILY CHARITABLE TRUST | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $44.6M | 3 |
| Columbia University Health Care Inc | New York | E32 Health Care | $44.5M | 8 |
| ST JOHNLAND NURSING CENTER INC | Kings Park | E91Z Health Care | $44.5M | 7 |
| BronxCare Special Care Center Inc | Bronx | E32Z Health Care | $44.4M | 8 |
| GRHS FOUNDATION INC | Rochester | S50Z Community Improvement & Capacity Building | $44.3M | 10 |
| Little Red School House INC | New York | — | $44.2M | 8 |
| NATIONAL CENTER FOR CIVIC INNOVATION IN | New York | S43 Community Improvement & Capacity Building | $44.2M | 4 |
| QUEENS COMMUNITY HOUSE | Forest Hills | P280 Human Services | $44.2M | 8 |
| HAWTHORNDEN FOUNDATION | New York | B82 Education | $44.1M | 3 |
| ARCUS FOUNDATION | New York | B82Z Education | $44M | 6 |
| JAZZ AT LINCOLN CENTER INC | New York | A680 Arts, Culture & Humanities | $44M | 15 |
