| MABEL PEW MYRIN TRUST | Philadelphia | — | $54.8M | 1 |
| SERVICE EMPLOYEES INTL UNION LOC 32BJ | Philadelphia | — | $54.5M | 8 |
| GATEWAY REHABILITATION CENTER | Moon Township | F220 Mental Health & Crisis Intervention | $54.3M | 13 |
| FULTON COUNTY MEDICAL CENTER | McConnellsburg | E22Z Health Care | $54.2M | 9 |
| NATIONAL COMPREHENSIVE CANCER NETWORK | Plymouth Meeting | E99Z Health Care | $53.8M | 11 |
| REA ENERGY COOPERATIVE INC | Indiana | — | $53.7M | 15 |
| DELAWARE VALLEY COMMUNITY HEALTH INC | Philadelphia | — | $53.4M | 9 |
| ECOG-ACRIN MEDICAL RESEARCH | Philadelphia | G05 Diseases, Disorders & Medical Disciplines | $53.3M | 5 |
| CHILDREN'S HOSPITAL OF PITTSBURGH | Pittsburgh | E11 Health Care | $53.2M | 7 |
| American Association for Cancer Research | Philadelphia | G30 Diseases, Disorders & Medical Disciplines | $52.9M | 8 |
| NORTH PHILADELPHIA HEALTH SYSTEM | Philadelphia | E210 Health Care | $52.9M | 11 |
| THIEL COLLEGE | Greenville | B420 Education | $52.7M | 11 |
| GEISINGER COMMONWEALTH SCH OF MED | Danville | B500 Education | $52.7M | 15 |
| CEDAR CREST COLLEGE | Allentown | B420 Education | $52.5M | 13 |
| SHARED SERVICES HEALTH PLAN TRUST | Lititz | Y43 Mutual & Membership Benefit | $52.5M | 0 |
| GARDEN SPOT VILLAGE | New Holland | P750 Human Services | $52.3M | 9 |
| IMMACULATA UNIVERSITY | Immaculata | B430 Education | $52M | 10 |
| BEAUMONT RETIREMENT SERVICES INC | Bryn Mawr | P750 Human Services | $51.9M | 9 |
| INVISION CUSTOMIZED SERVICES | Wexford | P70Z Human Services | $51.9M | 11 |
| PATHWAYS OF SOUTHWESTERN | Washington | P82 Human Services | $51.5M | 6 |
| PHILADELPHIA PERFORMING ARTS | Philadelphia | B290 Education | $51.4M | 7 |
| VALLEY YOUTH HOUSE COMMITTEE INC | Bethlehem | P300 Human Services | $51.3M | 5 |
| HEAVY & HIGHWAY CONSTRUCTION HEALTH AND | Philadelphia | — | $51.1M | 1 |
| THE MENNONITE HOME | Lancaster | P750 Human Services | $51.1M | 10 |
| GENEVA COLLEGE | Beaver Falls | B420 Education | $51M | 8 |
| CENTRAL ELECTRIC COOPERATIVE INC | Parker | — | $50.9M | 16 |
| MERAKEY ALLOS | Lafayette Hill | F33 Mental Health & Crisis Intervention | $50.9M | 12 |
| CONCORDIA VISITING NURSES | Cabot | E92 Health Care | $50.8M | 8 |
| WAYNE MEMORIAL COMMUNITY HEALTH CENTERS | Honesdale | E32 Health Care | $50.8M | 10 |
| WILLIAM PENN ASSOCIATION | Pittsburgh | — | $50.6M | 13 |
| PENNSYLVANIA PSYCHIATRIC INSTITUTE | Harrisburg | E24 Health Care | $50.5M | 8 |
| VIECARE BEAVER LLC | Cranberry Township | L20 Housing & Shelter | $50.5M | 8 |
| BEHAVIORAL HEALTH OF CAMBRIA COUNTY | Johnstown | E60 Health Care | $50.2M | 2 |
| ACTION-HOUSING INC | Pittsburgh | L800 Housing & Shelter | $50.2M | 5 |
| MEADOWOOD CORPORATION | Worcester | P750 Human Services | $50.2M | 7 |
| WHITEMARSH CONTINUING CARE RETIREMENT | Lafayette Hill | L220 Housing & Shelter | $50.1M | 9 |
| NORTHEAST TREATMENT CENTERS INC | Philadelphia | F22 Mental Health & Crisis Intervention | $50M | 7 |
| PERSON DIRECTED SUPPORTS INC | Whitehall | E60 Health Care | $50M | 9 |
| CAMBRIA COUNTY ASSOCIATION FOR THE BLIND | Johnstown | J33Z Employment | $49.6M | 9 |
| Anabaptist Foundation | Lewisburg | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $49.6M | 8 |
| CITY OF PHILADELPHIA TRUSTEE | Philadelphia | E220 Health Care | $49.6M | 9 |
| GEISINGER JERSEY SHORE HOSPITAL | Danville | E22Z Health Care | $49.5M | 15 |
| PATH (PEOPLE ACTING TO HELP) INC | Philadelphia | — | $49.4M | 14 |
| COMMUNITY ACTION COMMITTEE | Bethlehem | — | $49.3M | 3 |
| CANIZARES ANDERSON FOUNDATION INC | Gibsonia | — | $49.2M | 0 |
| DUNWOODY VILLAGE | Newtown Square | P750 Human Services | $48.8M | 7 |
| JEWISH FEDERATION OF GREATER PITTSBURGH | Pittsburgh | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $48.7M | 10 |
| UTILITIES EMPLOYEES CREDIT UNION | Reading | — | $48.3M | 19 |
| UFCW LOCAL 1776KS WESTERN DIVISION AND EMPLOYERS' HEALTH FUND | Canonsburg | — | $48.2M | 0 |
| Horizon House Rehabilitation Services Inc | Philadelphia | F22Z Mental Health & Crisis Intervention | $48.1M | 7 |
