| MAKE-A-WISH FOUNDATION OF AMERICA | Phoenix | — | $131M | 16 |
| United Food and Commercial Workers & Employers Desert States Health and Welfare Tr | Phoenix | — | $130.4M | 5 |
| RISE INC | Mesa | P820 Human Services | $127.7M | 12 |
| Bechtel Employees Disability and Medical Benefit Trust DBA Bechtel VEBA Trust | Glendale | — | $125.9M | 1 |
| TRICO ELECTRIC COOPERATIVE INC | Marana | — | $124.3M | 18 |
| Mt Graham Regional Medical Center Inc | Safford | E220 Health Care | $122.9M | 15 |
| Banner Medical Group Colorado | Phoenix | E31 Health Care | $120.5M | 11 |
| ADELANTE HEALTHCAREINC | Phoenix | E320 Health Care | $120.3M | 11 |
| VALLEY OF THE SUN UNITED WAY | Phoenix | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $119.5M | 7 |
| SULPHUR SPRINGS VALLEY ELECTRIC COOPERATIVE INC | Willcox | W80 Public & Societal Benefit | $118.5M | 30 |
| THE THUNDERBIRDS | Phoenix | — | $117.2M | 7 |
| Alliance Defending Freedom | Scottsdale | R600 Civil Rights, Social Action & Advocacy | $110.7M | 18 |
| TRUWEST CREDIT UNION | Tempe | — | $110.5M | 24 |
| DESERT MOUNTAIN CLUB INC | Scottsdale | N50 Recreation & Sports | $108.3M | 10 |
| Cobre Valley Regional Medical Center | Globe | E220 Health Care | $103.8M | 6 |
| Mohave Electric Cooperative Inc | Bullhead City | — | $103.5M | 20 |
| SOUTHWEST BEHAVIORAL HEALTH SERVICES INC | Phoenix | F30 Mental Health & Crisis Intervention | $102.9M | 9 |
| RECOVERY INNOVATIONS INC | Phoenix | F023 Mental Health & Crisis Intervention | $101.7M | 14 |
| TERROS INC | Phoenix | Z99Z Unknown | $98.5M | 12 |
| ARIZONA COMMUNITY FOUNDATION | Phoenix | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $95.2M | 15 |
| PORTABLE PRACTICAL EDUCATIONAL PREPARATION INC | Tucson | P200 Human Services | $95M | 3 |
| Marana Health Center Inc | Marana | E30 Health Care | $94.9M | 16 |
| GREASEWOOD SPRINGS COMMUNITY SCHOOL INC | Ganado | B24Z Education | $93.6M | 6 |
| CREDIT UNION WEST | Glendale | — | $93.5M | 25 |
| DIOCESAN COUNCIL FOR THE SOCIETY OF ST VINCENT DE PAUL DIOCESE PHOENIX | Phoenix | X22 Religion-Related | $92.7M | 10 |
| MARINE PRESERVATION ASSOCIATION | Phoenix | — | $92.5M | 2 |
| COMMUNITY FINANCE CORPORATION | Tucson | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $88M | 0 |
| BISBEE HOSPITAL ASSOCIATION INC | Bisbee | E220 Health Care | $88M | 8 |
| THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | Phoenix | H90 Medical Research | $85.9M | 17 |
| SOUTHWEST HUMAN DEVELOPMENT | Phoenix | — | $84.9M | 8 |
| BARROW NEUROLOGICAL FOUNDATION | Phoenix | G11 Diseases, Disorders & Medical Disciplines | $83.6M | 1 |
| Community Food Bank Inc | Tucson | K31Z Food, Agriculture & Nutrition | $83.4M | 4 |
| DONOR NETWORK OF ARIZONA | Tempe | E65 Health Care | $83.4M | 20 |
| ASU PREPARATORY ACADEMY INC | Tempe | B29 Education | $82.4M | 9 |
| NAVAJO HEALTH FOUNDATION - SAGE MEMORIAL HOSPITAL INC | Ganado | E220 Health Care | $79.1M | 17 |
| ARIZONA FOOD BANK NETWORK | Phoenix | K31C Food, Agriculture & Nutrition | $78.1M | 2 |
| EMPACT-SUICIDE PREVENTION CENTER | Tempe | F400 Mental Health & Crisis Intervention | $77.2M | 10 |
| SUN LIFE FAMILY HEALTH CENTER INC | Case Grande | E30Z Health Care | $77.1M | 9 |
| EDKEY INC | Mesa | B29 Education | $74.9M | 10 |
| ACADEMY OF MATHEMATICS AND SCIENCE SOUTH INC | Tempe | A25 Arts, Culture & Humanities | $74M | 7 |
| Arizona Pipe Trades Health & Welfare Trust Fund | Phoenix | — | $73.6M | 0 |
| Tempe Life Care Village Inc | Tempe | P750 Human Services | $73.2M | 7 |
| THE WYANT FOUNDATION TRUST | Tucson | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $71.1M | 0 |
| COPA HEALTH INC | Mesa | F02 Mental Health & Crisis Intervention | $69.8M | 9 |
| PETSMART CHARITIES INC | Phoenix | D122 Animal-Related | $68.7M | 0 |
| Garcia Family Foundation | Tempe | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $67.4M | 0 |
| TMC MEDICAL NETWORK | Tucson | E21 Health Care | $67.3M | 6 |
| Chiricahua Community Health Centers | Douglas | E30 Health Care | $66.7M | 12 |
| ARIZONA HYGIENE FOR HOPE | Surprise | P40 Human Services | $66.1M | 1 |
| SOLARI INC | Tempe | F40 Mental Health & Crisis Intervention | $65.2M | 13 |
