| L'REFUAH MEDICAL AND REHABILITATION CENTER INC | Brooklyn | E30 Health Care | $48.2M | 8 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS LOCAL 138 WELFARE FUND | Farmingdale | — | $48.2M | 13 |
| SERVICE EMPLOYEES BENEFIT FUND | Syracuse | Y43 Mutual & Membership Benefit | $48.2M | 1 |
| ANDERSON CENTER SERVICES | Staatsburg | — | $48.2M | 9 |
| BOB WOODRUFF FAMILY FOUNDATION INC | Long Island City | E99 Health Care | $48.1M | 7 |
| ALVIN AILEY DANCE FOUNDATION INC | New York | A620 Arts, Culture & Humanities | $48.1M | 11 |
| NEW YORK STATE PUBLIC EMPLOYEES FEDERATION | Albany | — | $48.1M | 12 |
| SUSTAINABLE MARKETS FOUNDATION | New York | C30 Environment | $48M | 0 |
| GOOD SHEPHERD HOSPICE | Farmingdale | — | $48M | 7 |
| ROCHESTER AREA COMMUNITY FOUNDATION | Rochester | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $47.9M | 7 |
| CATHOLIC CHARITIES OF THE DIOCESE OF ALBANY | Albany | — | $47.9M | 9 |
| BronxCare Dr Martin Luther King JrHealth Center | Bronx | — | $47.9M | 8 |
| ALL MY CHILDREN DAYCARE & NURSERY SCHOOL | Jamaica Estates | P33 Human Services | $47.8M | 6 |
| UNIVERSITY AT ALBANY FOUNDATION | Albany | B110 Education | $47.8M | 4 |
| ALLEGANY-STEUBEN COUNTIES CHAPTER NYSARCINC | Wellsville | P820 Human Services | $47.7M | 6 |
| POSTGRADUATE CENTER FOR MENTAL HEALTH | New York | — | $47.6M | 8 |
| FRANZISKA RACKER CENTERS INC | Ithaca | P820 Human Services | $47.6M | 6 |
| KIPP CAPITAL REGION PUBLIC CHARTER SCHOOLS | Albany | B29 Education | $47.4M | 10 |
| ACTIVE RETIREMENT COMMUNITY INC | South Setauket | L22 Housing & Shelter | $47.3M | 7 |
| LANTERN COMMUNITY SERVICES INC | New York | L21 Housing & Shelter | $47.3M | 8 |
| FOOD BANK OF CENTRAL NEW YORK | Syracuse | K31 Food, Agriculture & Nutrition | $47.2M | 3 |
| BASSETT HOSPITAL OF SCHOHARIE COUNTY | Cobleskill | E220 Health Care | $47.1M | 10 |
| WESTCHESTER COUNTRY CLUB | Rye | N50 Recreation & Sports | $47.1M | 9 |
| BROOKLYN ACADEMY OF MUSIC INC | Brooklyn | — | $47.1M | 15 |
| CDS LIFE TRANSITIONS INC | Webster | P11 Human Services | $47.1M | 9 |
| INTEGRATION CHARTER SCHOOLS | State Island | B25 Education | $47M | 15 |
| THE KENSICO CEMETERY | Valhalla | — | $46.9M | 18 |
| SOROS ECONOMIC DEVELOPMENT FUND | New York | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $46.9M | 0 |
| ANDERSON CENTER FOR AUTISM | Staatsburg | B20Z Education | $46.7M | 8 |
| ESSEX COUNTY CHAPTER NYSARC | Port Henry | P820 Human Services | $46.7M | 5 |
| GIVE LIVELY FOUNDATION INC | New York | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $46.7M | 0 |
| NATIONAL KIDNEY FOUNDATION INC | New York | G44Z Diseases, Disorders & Medical Disciplines | $46.7M | 13 |
| Hudson Valley Hospice Inc | Poughkeepsie | P74Z Human Services | $46.7M | 9 |
| NEIGHBORHOOD DEFENDER SERVICE INC | New York | — | $46.6M | 20 |
| BRONX FAMILY NETWORK INC | Yonkers | P85 Human Services | $46.5M | 4 |
| Village Care of New York Inc | New York | E210 Health Care | $46.5M | 8 |
| VNS HEALTH BEHAVIORAL HEALTH INC | New York | F32 Mental Health & Crisis Intervention | $46.4M | 10 |
| ACUMEN FUND INC | New York | Q123 International, Foreign Affairs & National Security | $46.4M | 14 |
| JOSEPH P ADDABBO FAMILY HEALTH CENTER INC | Arverne | — | $46.4M | 9 |
| NEW YORK INSTITUTE FOR SPECIAL EDUCATION | Bronx | B280 Education | $46.4M | 6 |
| TRUSTEES OF MASONIC HALL AND ASYLUM FUND | New York | P750 Human Services | $46.4M | 5 |
| GUIDING EYES FOR THE BLIND INC | Yorktown Heights | P860 Human Services | $46.4M | 13 |
| THE WINSTON PREPARATORY SCHOOL | New York | B28Z Education | $46.3M | 16 |
| UNITED WIRE METAL & MACHINE HEALTH & WE | Long Island City | — | $46.3M | 11 |
| BEHAVIORAL HEALTH SERVICES NORTH INC | Plattsburgh | F320 Mental Health & Crisis Intervention | $46.3M | 8 |
| NEW YORK FOUNDATION FOR SENIOR CITIZENS HOME ATTENDANT SERVICES INC | New York | — | $46.3M | 5 |
| CENTRAL NASSAU GUIDANCE AND COUNSELING SERVICES INC | Hicksville | F300 Mental Health & Crisis Intervention | $46.2M | 11 |
| UNITED CEREBRAL PALSY ASSOCIATION OF NASSAU COUNTY INC | Roosevelt | G200 Diseases, Disorders & Medical Disciplines | $46.1M | 9 |
| METROPOLITAN NEW YORK COORDINATING COUNCIL ON JEWISH POVERTY | New York | P200 Human Services | $46.1M | 7 |
| AMERICAN COUNCIL OF LEARNED SOCIETIES | New York | A030 Arts, Culture & Humanities | $46M | 8 |
