| WIRT COUNTY HEALTH SERVICES | Elizabeth | E39Z Health Care | $20.3M | 7 |
| CAMDEN ON GAULEY MEDICAL CENTER INC | Camden On Gauley | E22Z Health Care | $20.2M | 6 |
| BURLINGTON UNITED METHODIST FAMILY | Burlington | P40Z Human Services | $20.1M | 2 |
| WILLIAMSON HEALTH AND WELLNESS | Williamson | E32 Health Care | $19.6M | 7 |
| THE LINSLY SCHOOL INCORPORATED | Wheeling | B25Z Education | $19.5M | 1 |
| CENTRAL WEST VIRGINIA AGING SERVICES INC | Buckhannon | P81Z Human Services | $19.4M | 1 |
| West Virginia University Hospitals - East Inc | Martinsburg | E11 Health Care | $19.3M | 13 |
| SOUTHWESTERN COMMUNITY ACTION COUNCIL | Huntington | P81Z Human Services | $18.9M | 2 |
| MARSHALL UNIVERSITY REAL ESTATE FOUNDATION INC | Huntington | B11 Education | $18.9M | 1 |
| MOUNTAINHEART | Oceana | S200 Community Improvement & Capacity Building | $17.8M | 4 |
| HOSPICE OF THE PANHANDLE INC | Kearneysville | — | $17.8M | 9 |
| IBEW Local 82 Health & Welfare | Ona | — | $17.2M | 1 |
| LEGAL AID OF WEST VIRGINIA INC | Charleston | I80 Crime & Legal-Related | $17.2M | 5 |
| GRAFTON CITY HOSPITAL | Grafton | E22Z Health Care | $17.2M | 6 |
| VALLEY COMPREHENSIVE COMMUNITY HEALTH | Morgantown | — | $17.2M | 6 |
| BLUESTONE HEALTH ASSOCIATION INC | Princeton | E39Z Health Care | $17.2M | 7 |
| AUTISM SERVICES CENTER INC | Huntington | G84Z Diseases, Disorders & Medical Disciplines | $16.9M | 3 |
| WEBSTER MEMORIAL HOSPITAL | Webster Springs | E20 Health Care | $16.6M | 8 |
| Hardy Telecommunications Inc | Lost River | — | $16.5M | 15 |
| United Summit Center Inc | Clarksburg | F300 Mental Health & Crisis Intervention | $16.2M | 10 |
| FMRS HEALTH SYSTEMS INC | Beckley | F80Z Mental Health & Crisis Intervention | $15.9M | 7 |
| CAMC HEALTH EDUCATION AND RESEARCH | Charleston | B90Z Education | $15.9M | 20 |
| THE ELLIOT FOUNDATION INC | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.9M | 0 |
| North Central WV Community Action Assoc Inc | Fairmont | P20Z Human Services | $15.8M | 1 |
| BELINGTON COMMUNITY MEDICAL SERVICES | Belington | E39Z Health Care | $15.8M | 7 |
| HOSPICE OF SOUTHERN WEST VIRGINIA INC | Beckley | — | $15.7M | 1 |
| PRINCETON MEMORIAL COMPANY | Princeton | E91 Health Care | $15.7M | 6 |
| PRESTON TAYLOR COMMUNITY HEALTH CENTER | Grafton | E39Z Health Care | $15.2M | 7 |
| SENECA HEALTH SERVICES INC | Summersville | — | $15M | 8 |
| MONONGALIA HOME CORPORATION DBA SUNDALE | Morgantown | E91Z Health Care | $15M | 5 |
| ST GEORGE MEDICAL CLINIC INC | Parsons | — | $14.8M | 6 |
| APPALACHIAN TRAIL CONSERVANCY | Harpers Ferry | N32I Recreation & Sports | $14.6M | 6 |
| FOSTER FOUNDATION | Huntington | — | $14.5M | 2 |
| LOGAN-MINGO AREA MENTAL HEALTH INC | Logan | F30Z Mental Health & Crisis Intervention | $14.2M | 6 |
| WEST VIRGINIA STATE UNIVERSITY | Institute | — | $14.2M | 3 |
| MONONGALIA EMERGENCY MEDICAL SERVICES | Morgantown | E62Z Health Care | $14.2M | 9 |
| GENESIS YOUTH CRISIS CENTER INC | Clarksburg | P730 Human Services | $13.7M | 6 |
| YOUTH SERVICES SYSTEM INC | Wheeling | P300 Human Services | $13.7M | 2 |
| COMMUNITY ACTION OF SOUTH EASTERN | Bluefield | S310 Community Improvement & Capacity Building | $13.6M | 1 |
| HARRISON RURAL ELECTRIFICATION ASSO | Bridgeport | — | $13.5M | 8 |
| CAMC FOUNDATION INC | Charleston | E110 Health Care | $13.3M | 7 |
| EDGEWOOD SUMMIT INC | Charleston | P75Z Human Services | $13.1M | 2 |
| WVSU METRO AREA AGENCY ON AGING INC | Cross Lanes | P81Z Human Services | $13M | 1 |
| HOSPICE OF HUNTINGTON INC | Huntington | — | $12.9M | 6 |
| MONONGAHELA VALLEY ASSOC OF HEALTH | Fairmont | — | $12.9M | 9 |
| IRON WORKERS LOCALS 549 & 550 | Ona | Y40 Mutual & Membership Benefit | $12.4M | 0 |
| PENDLETON MANOR INC | Franklin | — | $12.4M | 5 |
| THS Physician Partners Inc | South Charleston | E60 Health Care | $12.4M | 9 |
| POTOMAC HIGHLANDS MENTAL HEALTH GUILD | Petersburg | F80Z Mental Health & Crisis Intervention | $12.4M | 2 |
| Grant Rehabilitation and Care Center Inc | Petersburg | P75 Human Services | $12.2M | 2 |
