| MICHIGAN VIRTUAL UNIVERSITY | Lansing | B300 Education | $24M | 8 |
| CLARK RETIREMENT COMMUNITY INC | Grand Rapids | L220 Housing & Shelter | $24M | 8 |
| SOUTH MICHIGAN FOOD BANK | Battle Creek | — | $23.9M | 1 |
| MIDMICHIGAN HEALTH SERVICES | Houghton Lake | E39Z Health Care | $23.8M | 12 |
| Credit Unions Chartered in the State of MI CASE Credit Union | Lansing | — | $23.8M | 8 |
| TRUENORTH COMMUNITY SERVICES | Fremont | P200 Human Services | $23.8M | 3 |
| REGION 3B AREA AGENCY ON AGING | Battle Creek | P810 Human Services | $23.7M | 2 |
| FOOD GATHERERS | Ann Arbor | — | $23.7M | 1 |
| WEST MICHIGAN CANCER CENTER | Kalamazoo | G30Z Diseases, Disorders & Medical Disciplines | $23.7M | 10 |
| GRAND ACTION FOUNDATION 20 | Grand Rapids | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $23.6M | 1 |
| GESHER HUMAN SERVICES | Southfield | J30 Employment | $23.5M | 9 |
| AMERICAN BOARD OF EMERGENCY MEDICINE | East Lansing | — | $23.5M | 27 |
| THE CASCADE PACE INC | Jackson | P81 Human Services | $23.4M | 11 |
| HENRY FORD PHYSICIAN PARTNERS | Detroit | E11 Health Care | $23.4M | 4 |
| Lakeland Immediate Care Center | Cassopolis | E32 Health Care | $23.2M | 9 |
| SPARTAN IMAGING INC | Lansing | E30 Health Care | $23.1M | 0 |
| PROBILITY THERAPY SERVICES | Ann Arbor | E50 Health Care | $23M | 9 |
| JOINT BOARD OF TRUSTEES IBEW LOCAL 252 HEALTH AND WELFARE TRUST FUND | Ann Arbor | — | $23M | 0 |
| RAHMA WORLDWIDE AID AND DEVELOPMENT | Beverly Hills | Q71 International, Foreign Affairs & National Security | $23M | 2 |
| THE ARBOR CIRCLE CORPORATION | Grand Rapids | P400 Human Services | $22.9M | 5 |
| THE PETER and JOAN SECCHIA FAMILY INC | Grand Rapids | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $22.8M | 1 |
| JUDSON CENTER INC | Farmington Hills | P700 Human Services | $22.8M | 11 |
| DETROIT BELLE ISLE GRAND PRIX INC | Bloomfield Hills | S990 Community Improvement & Capacity Building | $22.8M | 1 |
| JAMIE AND DENISE JACOB FAMILY PRIVATE FOUNDATION | Troy | O50 Youth Development | $22.7M | 0 |
| BERRIEN COMMUNITY FOUNDATION INC | St Joseph | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $22.7M | 2 |
| BETHANY CHRISTIAN SERVICES | Grand Rapids | P400 Human Services | $22.6M | 0 |
| COMERICA CHARITABLE TRUST | Detroit | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $22.6M | 0 |
| Presbyterian Village East | Chesterfield Twp | E91 Health Care | $22.6M | 7 |
| GROSFELD FOUNDATION | Southfield | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $22.5M | 0 |
| MCBRIDE QUALITY CARE SERVICES INC | Mt Pleasant | P70Z Human Services | $22.5M | 2 |
| MCLAREN CARO REGION | Caro | E220 Health Care | $22.2M | 8 |
| LOC CREDIT UNION | Farmington | — | $22.2M | 9 |
| MARY FREE BED ORTHOTICS AND PROSTHETICS | Grand Rapids | — | $22.1M | 11 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS' LOCAL 324 | Bloomfield Township | — | $22.1M | 13 |
| MID MICHIGAN COMMUNITY ACTION AGENCY INC | Farwell | — | $22M | 3 |
| LOCOMOTIVE ENGINEERS & CONDUCTORS MUTUAL PROTECTIVE ASSOCIATION | Southfield | — | $22M | 7 |
| ASSOC FOR ADVANCING AUTOMATION | Ann Arbor | — | $22M | 1 |
| THE SKILLMAN FOUNDATION | Detroit | B82 Education | $21.9M | 16 |
| UA Local 190 Health and Welfare Trust | Troy | — | $21.9M | 0 |
| THE MEIJER FOUNDATION | Grand Rapids | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21.8M | 2 |
| DOWNTOWN DETROIT PARTNERSHIP INC | Detroit | S20 Community Improvement & Capacity Building | $21.8M | 10 |
| New Paradigm for Education Inc | Detroit | B90 Education | $21.8M | 6 |
| Presbyterian Villages of Michigan | Southfield | P800 Human Services | $21.7M | 12 |
| WAYNE STATE UNIVERSITY FOUNDATION | Detroit | B432 Education | $21.7M | 10 |
| MGH FAMILY HEALTH CENTER MUSKEGON FAMILY CARE | Muskegon Heights | E32Z Health Care | $21.7M | 9 |
| SPARROW COMMUNITY CARE U OF M HLTH-SPARROW COMMUNITY CARE | Lansing | E92Z Health Care | $21.6M | 17 |
| DETROIT METRO CONVENTION AND VISITORS BUREAU | Detroit | — | $21.6M | 5 |
| MARSHALL COMMUNITY CREDIT UNION | Marshall | — | $21.6M | 4 |
| GRAND HAVEN AREA COMMUNITY FOUNDATION INC | Grand Haven | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $21.5M | 4 |
| Michigan Physical Fitness Health and Sports Foundation | Lansing | E70 Health Care | $21.4M | 6 |
