| MERCY MANAGEMENT OF SOUTHEASTERN | Newtown Square | E21Z Health Care | $41.6M | 12 |
| THE ACADEMY OF THE NEW CHURCH | Bryn Athyn | B420 Education | $41.4M | 12 |
| ATI-USW VEBA TRUST | Pittsburgh | Y43 Mutual & Membership Benefit | $41.3M | 2 |
| GEISINGER COMMUNITY HEALTH SERVICES | Danville | E30 Health Care | $41.1M | 13 |
| AMERICAN ELECTRIC POWER SYSTEM RETIREE | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $41.1M | 1 |
| HOPE INTERNATIONAL | Lancaster | Q300 International, Foreign Affairs & National Security | $41M | 4 |
| MERAKEY IDD PHILADELPHIA | Lafayette Hill | — | $40.9M | 9 |
| SARAH SCAIFE FOUNDATION INCORPORATED | Pittsburgh | — | $40.8M | 11 |
| PENNSWOOD VILLAGE | Newtown | P750 Human Services | $40.7M | 8 |
| SILVER SPRINGS - MARTIN LUTHER SCHOOL | Plymouth Meeting | P300 Human Services | $40.6M | 7 |
| PENNSYLVANIA LEGAL AID NETWORK INC | Harrisburg | I80Z Crime & Legal-Related | $40.5M | 3 |
| MOUNT ALOYSIUS COLLEGE | Cresson | B41Z Education | $40.2M | 10 |
| THE HIGHLANDS AT WYOMISSING | Wyomissing | P750 Human Services | $40M | 9 |
| WAVERLY HEIGHTS | Gladwyne | P750 Human Services | $39.9M | 14 |
| ST JOSEPHS CENTER | Scranton | P200 Human Services | $39.9M | 5 |
| CENTERVILLE CLINICS INC | Fredericktown | E210 Health Care | $39.9M | 6 |
| WILSON COLLEGE | Chambersburg | B420 Education | $39.7M | 9 |
| THE FRANKLIN INSTITUTE | Philadelphia | A25 Arts, Culture & Humanities | $39.6M | 14 |
| Electrolux VEBA for Collectively Barg | Pittsburgh | — | $39.5M | 1 |
| LACKAWANNA COLLEGE | Scranton | B41Z Education | $39.4M | 7 |
| LANCASTER GENERAL HEALTH | Lancaster | E120 Health Care | $39.4M | 35 |
| HOLCOMB ASSOCIATES INC | Exton | F30Z Mental Health & Crisis Intervention | $39.4M | 11 |
| First Philadelphia Preparatory Charter School | Philadelphia | B29 Education | $39.4M | 4 |
| METRO FAMILY PRACTICE INC | Pittsburgh | E30 Health Care | $39.1M | 8 |
| PENNSYLVANIA DIVISION HORSEMEN'S ASSOCIA | Grantville | — | $39.1M | 1 |
| PHOEBE HOME INC | Allentown | E910 Health Care | $39M | 8 |
| ABINGTON HEALTH FOUNDATION | Philadelphia | E110 Health Care | $38.7M | 1 |
| CORA SERVICES INC | Philadelphia | B20I Education | $38.7M | 5 |
| LA ROCHE UNIVERSITY | Pittsburgh | B430 Education | $38.6M | 11 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL | Philadelphia | — | $38.6M | 20 |
| TEAMSTERS 261 AND EMPLOYERS WELFARE FUND | New Castle | Y43 Mutual & Membership Benefit | $38.6M | 3 |
| MORAVIAN MANORS INC | Lititz | E910 Health Care | $38.5M | 8 |
| Avon Grove Charter School | West Grove | B29 Education | $38.4M | 9 |
| THE STEINMAN FOUNDATION | Lancaster | — | $38.2M | 1 |
| Granite State Electric Co Post Ret Bnft | Pittsburgh | — | $38.2M | 1 |
| REDSTONE PRESBYTERIAN SENIORCARE | Greensburg | P75 Human Services | $38.1M | 8 |
| Vision Benefits of America Inc | Carnegie | — | $38.1M | 17 |
| CHILDREN AND ADULT DISABILITY | Swarthmore | — | $38M | 7 |
| WELLSPAN HEALTH CARE SERVICES | York | E21Z Health Care | $38M | 9 |
| THE PENNSYLVANIA HORTICULTURAL SOCIETY | Philadelphia | C420 Environment | $37.8M | 8 |
| TEAMSTERS LOCAL 830 WELFARE PLAN | Philadelphia | — | $37.7M | 5 |
| Saint Joseph Villa | Flourtown | — | $37.4M | 6 |
| LABORER'S DISTRICT COUNCIL BUILDING & | Philadelphia | — | $37.3M | 1 |
| PENN ASIAN SENIOR SERVICES INC | Philadelphia | E92 Health Care | $37.2M | 1 |
| PHOEBE SERVICES INC | Allentown | S500 Community Improvement & Capacity Building | $37.1M | 11 |
| ACHIEVA SUPPORT | Pittsburgh | P82 Human Services | $37.1M | 12 |
| RIDDLE VILLAGE | Media | P750 Human Services | $37M | 7 |
| VNA OF ST LUKE'S - HOME HEALTHHOSPICE INC | Allentown | P740 Human Services | $37M | 7 |
| CITIZEN CARE INC | McKees Rocks | P820 Human Services | $36.9M | 3 |
| KIDSPEACE CORPORATION | Schnecksville | F020 Mental Health & Crisis Intervention | $36.9M | 11 |
