| Concordia Care Network | Cabot | G02 Diseases, Disorders & Medical Disciplines | $50.1M | 15 |
| NORTHEAST TREATMENT CENTERS INC | Philadelphia | F22 Mental Health & Crisis Intervention | $50M | 7 |
| PERSON DIRECTED SUPPORTS INC | Whitehall | E60 Health Care | $50M | 9 |
| FULTON FINANCIAL CORP EMPLOYEE BENEFIT TRUST | Lancaster | — | $49.8M | 0 |
| APIS Services Inc | Reading | E11 Health Care | $49.8M | 16 |
| CAMBRIA COUNTY ASSOCIATION FOR THE BLIND AND HANDICAPPED | Johnstown | J33Z Employment | $49.6M | 9 |
| Anabaptist Foundation | Lewisburg | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $49.6M | 8 |
| CITY OF PHILADELPHIA TRUSTEE ADMINISTERING WILLS EYE HOSPITAL | Philadelphia | E220 Health Care | $49.6M | 9 |
| ACCESS SERVICES INC | Fort Washington | — | $49.3M | 7 |
| THE ACADEMY OF THE NEW CHURCH | Bryn Athyn | B420 Education | $49.3M | 15 |
| CANIZARES ANDERSON FOUNDATION INC | Gibsonia | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $49.2M | 0 |
| First Philadelphia Preparatory Charter School | Philadelphia | B29 Education | $48.9M | 5 |
| DUNWOODY VILLAGE | Newtown Square | P750 Human Services | $48.8M | 7 |
| WAYNE MEMORIAL COMMUNITY HEALTH CENTERS | Honesdale | E32 Health Care | $48.7M | 11 |
| WHYY INC | Philadelphia | A300 Arts, Culture & Humanities | $48.5M | 14 |
| GEMMA SERVICES | Plymouth Meeting | P300 Human Services | $48.4M | 5 |
| UTILITIES EMPLOYEES CREDIT UNION | Reading | — | $48.3M | 19 |
| Horizon House Rehabilitation Services Inc | Philadelphia | F22Z Mental Health & Crisis Intervention | $48.1M | 7 |
| THE BRETHREN HOME COMMUNITY | New Oxford | P750 Human Services | $48.1M | 8 |
| LANCASTER BIBLE COLLEGE | Lancaster | B58Z Education | $47.9M | 7 |
| YMCA OF GREATER BRANDYWINE | West Chester | P27 Human Services | $47.9M | 11 |
| The Wright Center for Graduate Medical Education | Scranton | G95Z Diseases, Disorders & Medical Disciplines | $47.9M | 18 |
| JEWISH FEDERATION OF GREATER PITTSBURGH | Pittsburgh | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $47.8M | 9 |
| Keyspan Corp Life Ins Master Trust For Mgmt Employees | Pittsburgh | Y43 Mutual & Membership Benefit | $47.7M | 1 |
| VIECARE BEAVER LLC | Cranberry Township | L20 Housing & Shelter | $47.6M | 8 |
| Cen-Clear Child Services Inc | Woodland | P300 Human Services | $47.4M | 6 |
| CARNEGIE LIBRARY OF PITTSBURGH | Pittsburgh | B70 Education | $47.3M | 8 |
| Welfare Benefits Funding Plan for Employees of Temple University | Philadelphia | — | $47.3M | 0 |
| COMMUNITY ACTION COMMITTEE OF THE LEHIGH VALLEY INC | Bethlehem | — | $47.2M | 3 |
| NATIONAL HOCKEY LEAGUE PLAYERS' HEALTH AND BENEFITS FUND | Pittsburgh | Y44 Mutual & Membership Benefit | $46.9M | 0 |
| LYCOMING COUNTY INSURANCE CONSORTIUM POOLED TRUST | Canton | — | $46.6M | 0 |
| MERAKEY IDD PHILADELPHIA | Lafayette Hill | — | $46.6M | 9 |
| PATH (PEOPLE ACTING TO HELP) INC | Philadelphia | — | $46.6M | 12 |
| Pacific Gas & Electric Post Ret Med Pl Tr Mgt & Non-Barg Unit | Pittsburgh | — | $46.5M | 1 |
| UNION COMMUNITY CARE | Lancaster | E34Z Health Care | $46.5M | 10 |
| STEAMFITTERS 449 MEDICAL & BENEFIT FUND | Harmony | — | $46.4M | 0 |
| UNITED STATES CATHOLIC CONFERENCE MCGUIRE MEMORIAL HOME | New Brighton | P700 Human Services | $46.2M | 11 |
| MOUNT ALOYSIUS COLLEGE | Cresson | B41Z Education | $46.1M | 11 |
| Radiology Associates of Children's Hospital Inc | Philadelphia | E31 Health Care | $46M | 12 |
| Tri-County Electric Cooperative Inc | Mansfield | — | $45.7M | 18 |
| RIVER CROSSING YOUNG MEN'S CHRISTIAN ASSOCIATION | Doylestown | P27Z Human Services | $45.6M | 10 |
| ARC HUMAN SERVICES INC | Canonsburg | P82Z Human Services | $45.5M | 5 |
| CO-MHAR Inc | Philadelphia | F30Z Mental Health & Crisis Intervention | $45.4M | 10 |
| Asociacion De Puertorriquenos En Marcha Inc | Philadelphia | P84Z Human Services | $45.4M | 6 |
| TRUMERIT | Philadelphia | E60 Health Care | $45.3M | 8 |
| Eversource Retirees Benefit Trust | Pittsburgh | — | $45M | 1 |
| PENNSYLVANIA COALITION AGAINST DOMESTIC VIOLENCE | Harrisburg | — | $44.8M | 6 |
| THE ROBERT MCLEAN AND JENEPHER AND EDWARD J KELLY JR FOUNDATION | Holicong | P12 Human Services | $44.2M | 1 |
| VERLAND FOUNDATION INC | Sewickley | P730 Human Services | $44M | 6 |
| HAMILTON FAMILY CHARITABLE TRUST | Wayne | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $43.9M | 5 |
