| THE JEWISH HEALTHCARE FOUNDATION | Pittsburgh | E192 Health Care | $33M | 6 |
| COMMONWEALTH CORNERSTONE GROUP | Harrisburg | S30 Community Improvement & Capacity Building | $33M | 5 |
| WESTERN PENNSYLVANIA CONSERVANCY | Pittsburgh | C340 Environment | $32.8M | 12 |
| SCIENCE HISTORY INSTITUTE SUPPORT | Philadelphia | B700 Education | $32.7M | 9 |
| Behavioral Health Services of Somerset & | Somerset | P50 Human Services | $32.6M | 1 |
| CITIZENS ACTING TOGETHER CAN HELP INC | Philadelphia | P82Z Human Services | $32.6M | 8 |
| INDIANA HEALTHCARE PHYSICIAN | Indiana | E30 Health Care | $32.4M | 9 |
| TRUST FOR VERIZON LONG TERM DISABILITY VEBA | Pittsburgh | — | $32.4M | 1 |
| WESTERN PENNSYLVANIA SCHOOL FOR THE DEAF | Pittsburgh | B280 Education | $32.4M | 8 |
| A SECOND CHANCE INC | Pittsburgh | P300 Human Services | $32.4M | 10 |
| PETER BECKER COMMUNITY | Harleysville | Z99Z Unknown | $32.4M | 10 |
| THE KINTOCK GROUP OF NEW JERSEY INC | Fort Washington | P20 Human Services | $32.3M | 10 |
| THE PHILADELPHIA PROTESTANT HOME | Philadelphia | P750 Human Services | $32.2M | 9 |
| NRG ONCOLOGY FOUNDATION INC | Philadelphia | H30 Medical Research | $32.2M | 1 |
| EASTERN NATIONAL | Fort Washington | N190 Recreation & Sports | $32.2M | 9 |
| NEW FOUNDATIONS CHARTER SCHOOL | Philadelphia | B24 Education | $32M | 6 |
| ABILITIES IN MOTION | Reading | — | $32M | 1 |
| B LAB COMPANY | Philadelphia | W03 Public & Societal Benefit | $32M | 12 |
| REVIVAL TODAY INC | Coraopolis | X20 Religion-Related | $32M | 2 |
| ACADEMY IN MANAYUNK | Conshohocken | B24 Education | $32M | 8 |
| WILLS EYE OPHTHALMOLOGY | Philadelphia | H19 Medical Research | $32M | 15 |
| THE LENFEST INSTITUTE FOR JOURNALISM | Philadelphia | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $32M | 11 |
| MATHEMATICS SCIENCE AND TECHNOLOGY | Philadelphia | B20 Education | $31.8M | 6 |
| ARMCO CREDIT UNION | Butler | — | $31.8M | 7 |
| DELTA COMMUNITY SUPPORTS INC (PA) | Blue Bell | P820 Human Services | $31.7M | 8 |
| ALEXS LEMONADE STAND FOUNDATION | Wynnewood | — | $31.7M | 7 |
| LIFESTEPS INC | Butler | B99 Education | $31.7M | 5 |
| PASSAVANT RETIREMENT AND HEALTH CENTER | Cranberry Township | P750 Human Services | $31.6M | 8 |
| LENAPE VALLEY FOUNDATION | Doylestown | F30Z Mental Health & Crisis Intervention | $31.6M | 8 |
| PLUMBERS LOCAL UNION NO 690 HEALTH PLAN | Philadelphia | — | $31.6M | 6 |
| KIDSPEACE CHILDREN'S HOSPITAL | Schnecksville | — | $31.4M | 8 |
| VERLAND FOUNDATION INC | Sewickley | P730 Human Services | $31.4M | 3 |
| CLAVERACK RURAL ELECTRIC COOPERATIVE | Wysox | — | $31.4M | 17 |
| MERAKEY PHILADELPHIA | Lafayette Hill | F320 Mental Health & Crisis Intervention | $31.3M | 9 |
| Presbyterian SeniorCare | Oakmont | P750 Human Services | $31.3M | 11 |
| ARCONIC FOUNDATION | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $31.2M | 0 |
| FAMILY FIRST HEALTH CORPORATION | York | E320 Health Care | $31.1M | 10 |
| ONCOLOGY NURSING SOCIETY | Pittsburgh | — | $31.1M | 10 |
| ASPIRA INC OF PENNSYLVANIA | Philadelphia | — | $31M | 5 |
| MARIANA BRACETTI ACADEMY CHARTER SCHOOL | Philadelphia | B29 Education | $31M | 13 |
| HERITAGE VALLEY HEALTH SYSTEMINC | Beaver | E210 Health Care | $31M | 6 |
| BUTLER COUNTY CHILDREN'S CENTER INC | Butler | P33Z Human Services | $31M | 3 |
| Propel Schools Inc | Pittsburgh | B29 Education | $31M | 15 |
| THE ARC OF CHESTER COUNTY | West Chester | — | $31M | 4 |
| ARTSQUEST | Bethlehem | A200 Arts, Culture & Humanities | $30.9M | 5 |
| APIS Services Inc | Reading | E11 Health Care | $30.9M | 10 |
| COMMUNITY FOUNDATION OF GREATER | Johnstown | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $30.5M | 2 |
| CENTER FOR COMMUNITY ACTION | Everett | L99Z Housing & Shelter | $30.5M | 2 |
| MASTERY CHARTER SCHOOL - THOMAS CAMPUS | Philadelphia | B29 Education | $30.5M | 7 |
| ZOOLOGICAL SOCIETY OF PITTSBURGH | Pittsburgh | D500 Animal-Related | $30.5M | 7 |
