| UNIVERSITY OF MARYLAND FOUNDATION INC | Adelphi | B110 Education | $77.1M | 10 |
| INFINITE LEGACY INC | Baltimore | E65 Health Care | $76.7M | 15 |
| ALBRIGHT CARE SERVICES | Frederick | P750 Human Services | $76.4M | 13 |
| THE HARVEY M MEYERHOFF FUND INC | Baltimore | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $75.4M | 1 |
| AMERICAN SPEECH-LANGUAGE-HEARING ASSOCIATION | Rockville | — | $75.3M | 13 |
| MARYLAND EMERGENCY MEDICINE NETWORK INC | Baltimore | E70 Health Care | $74.8M | 14 |
| NATIONAL AQUARIUM INC | Baltimore | D500 Animal-Related | $74.4M | 11 |
| PLAYERS PHILANTHROPY FUND INC | Towson | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $73.2M | 0 |
| Mt Washington Pediatric Hospital Inc | Baltimore | E240 Health Care | $72.9M | 13 |
| LUTHERAN WORLD RELIEF INC | Baltimore | Q330 International, Foreign Affairs & National Security | $72.1M | 18 |
| Maryland Family Care Inc | Baltimore | — | $70.9M | 18 |
| MARYLAND LEGAL SERVICES CORPORATION | Baltimore | I80Z Crime & Legal-Related | $70.9M | 2 |
| FISHER HOUSE FOUNDATION INC | Rockville | Z99Z Unknown | $70M | 12 |
| NAF HOTLINE FUND | Annapolis Junction | E194 Health Care | $69.8M | 4 |
| BULLIS SCHOOL | Potomac | B200 Education | $69.7M | 8 |
| THE JEWISH FEDERATION OF GREATER WASHINGTON INC | North Bethesda | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $69.4M | 7 |
| SHERMAN FAIRCHILD FOUNDATION INC | Chevy Chase | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $68.8M | 12 |
| ADVENTIST REHABILITATION HOSPITAL OF MARYLAND INC | Gaithersburg | E22 Health Care | $68.4M | 16 |
| KENNEDY KRIEGER EDUCATION AND COMMUNITY SERVICES INC | Baltimore | S200 Community Improvement & Capacity Building | $68.2M | 14 |
| HEBREW HOME OF GREATER WASHINGTON INC | Rockville | E91 Health Care | $68M | 9 |
| CHESAPEAKE LIGHTHOUSE FOUNDATION INC | Laurel | B29 Education | $67.6M | 7 |
| THE GOG FOUNDATION INC | Edgewater | H30 Medical Research | $66.1M | 13 |
| COMMUNITY SERVICES FOR AUTISTIC ADULTS & | Montgomery Village | G84Z Diseases, Disorders & Medical Disciplines | $65.2M | 5 |
| MEDSTAR HEALTH VISITING NURSE ASSOCIATION INC | Calverton | — | $65.2M | 10 |
| AMERICAN SOCIETY OF HEALTH-SYSTEM PHARMACISTS (ASHP) | Bethesda | — | $64.9M | 26 |
| UNIVERSITY OF MARYLAND PHYSICIANS PA | Baltimore | — | $64.9M | 12 |
| Total Health Care Inc | Baltimore | E310 Health Care | $64.5M | 11 |
| LOCKHEED MARTIN CORP BENEFIT TRUST FOR COLLECTIVELY BARGAINED EMPLOYEES VEBA II | Bethesda | — | $64.4M | 1 |
| ADVENTIST HEALTHCARE FORT WASHINGTON MEDICAL CENTER INC | Gaithersburg | — | $64.4M | 12 |
| BRIGHTFOCUS FOUNDATION | Clarksburg | G00J Diseases, Disorders & Medical Disciplines | $63.4M | 10 |
| NOTRE DAME OF MARYLAND UNIVERSITY INC | Baltimore | B430 Education | $63.2M | 11 |
| THE MORNINGSTAR PHILANTHROPIC FOUNDATION D/B/A THE MORNINGSTAR FOUNDATION | Bethesda | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $62.6M | 0 |
| THE MARYLAND SCHOOL FOR THE BLIND | Baltimore | B280 Education | $61.7M | 7 |
| ELEVATOR INDUSTRY WORK PRESERVATION FUND | Columbia | — | $61.4M | 16 |
| Foundation for the National Institutes of Health Inc | North Bethesda | H920 Medical Research | $61M | 13 |
| US NAVAL ACADEMY FOUNDATION INC | Annapolis | B12 Education | $60.7M | 13 |
| NAACP EMPOWERMENT PROGRAMS INC | Baltimore | R22 Civil Rights, Social Action & Advocacy | $60.6M | 12 |
| BALTIMORE COMMUNITY FOUNDATION INC | Baltimore | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $60.6M | 9 |
| University of Maryland Community Medical Group Inc | Easton | E320 Health Care | $60.1M | 19 |
| NATIONAL CENTER FOR CHILDREN AND FAMILIES | Bethesda | P430 Human Services | $59.6M | 8 |
| MEDSTAR HEALTH RESEARCH INSTITUTE INC | Columbia | — | $59.5M | 10 |
| BROOKE GROVE FOUNDATION INC | Sandy Spring | E910 Health Care | $59.1M | 12 |
| Harford Memorial Hospital Inc | Havre De Grace | E220 Health Care | $58.4M | 12 |
| HEALTH AND WELFARE TRUST FUND FOR IUOE LOCAL 99 & 99A | Baltimore | — | $58.1M | 3 |
| DIGITAL HARBOR FOUNDATION | Baltimore | B82 Education | $57.9M | 8 |
| CWI WORKS INC | Silver Spring | P810 Human Services | $57.8M | 9 |
| ENOCH PRATT FREE LIBRARY OF BALTIMORE CITY | Baltimore | B71Z Education | $57.3M | 10 |
| COMMUNITY SUPPORT SERVICES INC | Gaithersburg | P820 Human Services | $57.2M | 10 |
| HJF MEDICAL RESEARCH INTERNATIONAL INC | Bethesda | G40 Diseases, Disorders & Medical Disciplines | $57M | 11 |
| CRISP SHARED SERVICES INC | Columbia | E70 Health Care | $56.8M | 15 |
