| Memorial Hermann Hospital Based Physician Group | Houston | E62 Health Care | $105.8M | 8 |
| TRINITY BROADCASTING OF TEXAS | Fort Worth | X820 Religion-Related | $105.3M | 9 |
| LONE STAR CIRCLE OF CARE | Georgetown | E30 Health Care | $105M | 15 |
| Cook Children's Medical Center - Prosper | Fort Worth | E20 Health Care | $104.7M | 18 |
| LeTourneau University | Longview | B430 Education | $104M | 9 |
| Mother Frances Hospital - Jacksonville | Irving | E21 Health Care | $103.2M | 13 |
| The Susan G Komen Breast Cancer Foundation Inc | Dallas | G320 Diseases, Disorders & Medical Disciplines | $102.9M | 12 |
| NUECES ELECTRIC COOPERATIVE INC | Robstown | — | $102.7M | 17 |
| CATHOLIC CHARITIES OF THE ARCHDIOCESE OF GALVESTON - HOUSTON | Houston | P20Z Human Services | $102.6M | 13 |
| TEXAS WESLEYAN UNIVERSITY | Fort Worth | B430 Education | $102.1M | 11 |
| ALLIED PILOTS ASSOCIATION WELFARE BENEFITS PLAN MASTER TRUST | Fort Worth | — | $101.1M | 1 |
| ATLANTIC HOUSING FOUNDATION INC | Dallas | L25 Housing & Shelter | $101M | 15 |
| DATCU | Corinth | — | $100.5M | 20 |
| LOWER RIO GRANDE VALLEY WORKFORCE DEVELOPMENT BOARD INC | McAllen | J20 Employment | $100.3M | 3 |
| JE AND LE MABEE FOUNDATION INC | Midland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $100.3M | 7 |
| HILCO ELECTRIC COOPERATIVE INC | Itasca | — | $99.5M | 16 |
| TEXAS ASSOCIATION OF SCHOOL BOARDS INC | Austin | B030 Education | $98.8M | 16 |
| TEXAS GUARANTEED STUDENT LOAN CORPORATION | Round Rock | W600 Public & Societal Benefit | $98.5M | 22 |
| WISE ELECTRIC COOPERATIVE INC | Decatur | — | $98.4M | 16 |
| EL CENTRO DEL BARRIO INC | San Antonio | P200 Human Services | $97.6M | 10 |
| ST LUKE'S COMMUNITY DEVELOPMENT CORPORATION - SUGAR LAND | Houston | E20 Health Care | $97.2M | 10 |
| EDUCATION SERVICE CENTER REGION XIII | Austin | B99Z Education | $96.8M | 15 |
| TRINITY BASIN PREPARATORY INC | Grand Prairie | B20 Education | $96.4M | 7 |
| COMMUNITY FOUNDATION OF NORTH TEXAS (TAX | Fort Worth | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $96.4M | 5 |
| Texas A&M University 12th Man Foundation | College Station | B820 Education | $95.7M | 11 |
| WI Cook Foundation Inc | Fort Worth | E11 Health Care | $95.1M | 16 |
| ST LUKE'S HEALTH SYSTEM CORPORATION | Houston | E60Z Health Care | $94.2M | 13 |
| TEXAS PROPERTY AND CASUALTY INSURANCE GUARANTY ASSOCIATION | Austin | — | $94.1M | 8 |
| Jubilee Academic Center Inc | San Antonio | B29 Education | $94M | 14 |
| Huntsville Community Hospital Inc | Huntsville | E22 Health Care | $93.8M | 14 |
| MULTIPURPOSE ARENA FORT WORTH | Fort Worth | N19 Recreation & Sports | $93.6M | 9 |
| TEXAS TECH FOUNDATION INC | Lubbock | B110 Education | $92.7M | 2 |
| VANGUARD ACADEMY INC | Edinburg | B112 Education | $92.2M | 5 |
| LIFEGIFT ORGAN DONATION CENTER | Houston | E61Z Health Care | $92.1M | 11 |
| Texas Medical Center Central Heating and Cooling Services Corporation | Houston | E60 Health Care | $91.7M | 11 |
| AMPLIFY CREDIT UNION | Austin | — | $91.5M | 40 |
| GOODWILL INDUSTRIES OF SAN ANTONIO | San Antonio | — | $91.2M | 11 |
| FIRST SERVICE CREDIT UNION | Houston | — | $91.1M | 21 |
| SOUTHWEST ARKANSAS ELECTRIC COOPERATIVE CORP | Texarkana | — | $91M | 20 |
| SOUTHWEST TRANSPLANT ALLIANCE INC | Dallas | E65Z Health Care | $90.7M | 8 |
| WOOD COUNTY ELECTRIC COOPERATIVE | Quitman | — | $90.4M | 15 |
| NATIONAL CAMPUS AND COMMUNITY DEVELOPMENT CORPORATION | Austin | L22 Housing & Shelter | $90.1M | 3 |
| Episcopal Health Foundation | Houston | E70 Health Care | $88.7M | 9 |
| Memorial Hermann Foundation | Houston | E110 Health Care | $88.6M | 6 |
| Children's Physician Services of South Texas | Corpus Christi | E320 Health Care | $88.5M | 12 |
| UNITED HERITAGE CREDIT UNION | Austin | — | $88.2M | 29 |
| Brazos Education Loan Authority Inc | Waco | B82 Education | $88.2M | 6 |
| St John's School | Houston | — | $88.2M | 11 |
| RIO GRANDE ELECTRIC COOP INC | Brackettville | — | $88.2M | 23 |
| Alamo Trust Inc | San Antonio | A54 Arts, Culture & Humanities | $87.5M | 8 |
