| Tarrant Area Food Bank | Fort Worth | — | $135M | 10 |
| JE AND LE MABEE FOUNDATION INC | Midland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $134.6M | 7 |
| Scott & White Hospital-Marble Falls | Dallas | E22 Health Care | $134.4M | 21 |
| Hendrick Medical Center Brownwood | Abilene | E22 Health Care | $133.6M | 18 |
| GULF COAST REGIONAL BLOOD CENTER | Houston | E610 Health Care | $132.7M | 16 |
| Texas Children's Health Plan The Center | Bellaire | E99 Health Care | $131.3M | 15 |
| Qualtex Laboratories | San Antonio | E61 Health Care | $129.4M | 7 |
| METHODIST PRIMARY CARE GROUP | Houston | T110 Philanthropy, Voluntarism & Grantmaking Foundations | $129M | 21 |
| KARNES ELECTRIC COOPERATIVE INC | Karnes City | — | $128M | 14 |
| TEXAS MEDICAL CENTER | Houston | E210 Health Care | $127.7M | 17 |
| AIDS ARMS INC | Dallas | G81Z Diseases, Disorders & Medical Disciplines | $127.3M | 16 |
| BANK OF AMERICA SHORT TERM DISABILITY TRUST | Dallas | Y43 Mutual & Membership Benefit | $126.8M | 0 |
| KNAPP MEDICAL CENTER | Weslaco | E220 Health Care | $126.3M | 9 |
| TEXAS LIFE AND HEALTH INSURANCE | Austin | — | $123.5M | 2 |
| AMERICAN ATHLETIC CONFERENCE | Irving | — | $123.4M | 8 |
| Memorial Hermann Pharmacy Services LLC | Houston | E60 Health Care | $123.2M | 4 |
| Houston Endowment Inc | Houston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $122.6M | 3 |
| Texas A&M University 12th Man Foundation | College Station | B820 Education | $121M | 9 |
| TEXAS TRUST CREDIT UNION | Arlington | — | $119.5M | 9 |
| Burlington Northern Santa Fe Welfare Benefit Trust | Fort Worth | — | $118M | 1 |
| LUTHERAN SOCIAL SERVICES OF THE | Austin | P200 Human Services | $117.8M | 15 |
| University of St Thomas | Houston | B430 Education | $115.5M | 14 |
| AUSTIN COMMUNITY FOUNDATION INC | Austin | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $114.7M | 6 |
| BANDERA ELECTRIC COOPERATIVE INC | Bandera | — | $114.4M | 24 |
| Baylor Scott & White Medical Centers- | Dallas | E20 Health Care | $114.2M | 20 |
| ACH CHILD AND FAMILY SERVICES | Fort Worth | — | $113.9M | 9 |
| Shannon Medical Management | San Angelo | E19 Health Care | $113.6M | 9 |
| University of Dallas | Irving | B42Z Education | $113.2M | 25 |
| HILCO ELECTRIC COOPERATIVE INC | Itasca | — | $111.9M | 16 |
| Great Hearts America-Texas | San Antonio | C27 Environment | $110.8M | 14 |
| UPSHUR-RURAL ELECTRIC COOPERATIVE CORPORATION | Gilmer | — | $110.6M | 18 |
| CHILDREN'S MEDICAL CENTER FOUNDATION | Dallas | E11 Health Care | $109.8M | 4 |
| DEEP EAST TEXAS ELECTRIC | San Augustine | — | $109.3M | 19 |
| IBEW-NECA SOUTHWESTERN HEALTH & BENEFIT FUND | Dallas | — | $108.2M | 0 |
| ST LUKE'S HEALTH SYSTEM CORPORATION | Houston | E60Z Health Care | $108.2M | 11 |
| SAN ANTONIO AREA FOUNDATION | San Antonio | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $108M | 10 |
| METHODIST RETIREMENT COMMUNITIES | The Woodlands | — | $107.3M | 7 |
| IPS Enterprises Inc | Weslaco | B19 Education | $107.1M | 11 |
| ST LUKE'S HOSPITAL AT THE VINTAGE | Houston | E21 Health Care | $107M | 6 |
| O'DONNELL FOUNDATION | Dallas | — | $106.9M | 3 |
| BAYLOR ST LUKE'S MEDICAL GROUP | Houston | E110 Health Care | $106.9M | 11 |
| SAN BERNARD ELECTRIC COOPERATIVE INC | Bellville | — | $105.9M | 18 |
| TRINITY BROADCASTING OF TEXAS | Fort Worth | X820 Religion-Related | $105.3M | 9 |
| LONE STAR CIRCLE OF CARE | Georgetown | E30 Health Care | $105M | 15 |
| Cook Children's Medical Center - Prosper | Fort Worth | E20 Health Care | $104.7M | 18 |
| WISE ELECTRIC COOPERATIVE INC | Decatur | — | $104.4M | 16 |
| The Susan G Komen Breast Cancer Foundation Inc | Dallas | G320 Diseases, Disorders & Medical Disciplines | $102.9M | 12 |
| NUECES ELECTRIC COOPERATIVE INC | Robstown | — | $102.7M | 17 |
| TEXAS WESLEYAN UNIVERSITY | Fort Worth | B430 Education | $102.1M | 11 |
| ATLANTIC HOUSING FOUNDATION INC | Dallas | L25 Housing & Shelter | $101M | 15 |
