| ST JOSEPH'S AREA HEALTH SERVICES | Park Rapids | E22 Health Care | $51M | 13 |
| Fairview Bethesda Hospital | Minneapolis | E220 Health Care | $50.8M | 24 |
| SOUTH METRO HUMAN SERVICES | St Paul | P200 Human Services | $50.5M | 13 |
| SAINT THERESE COMMUNITIES | St Louis Park | — | $50.2M | 7 |
| ARROWHEAD ECONOMIC OPPORTUNITY AGENCY INCORPORATED | Virginia | — | $49.9M | 10 |
| MINNEAPOLIS SOCIETY OF FINE ARTS DBA MINNEAPOLIS INSTITUTE OF ARTS | Minneapolis | A510 Arts, Culture & Humanities | $49.8M | 13 |
| SLAGGIE FAMILY FOUNDATION | Winona | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $49.5M | 0 |
| INDEPENDENT COMMUNITY BANKERS OF AMERICA | Sauk Centre | — | $49.1M | 32 |
| THRIVENT FINANCIAL FOR LUTHERANS-GROUP | Minneapolis | — | $49M | 0 |
| CENTRACARE HEALTH SYSTEM - SAUK CENTRE | Sauk Centre | E20 Health Care | $47.8M | 16 |
| DEER RIVER HEALTHCARE CENTER INC | Deer River | E20Z Health Care | $47.1M | 11 |
| UCARE HEALTH INC | Minneapolis | E99 Health Care | $46.9M | 7 |
| Hmong College Prep Academy | St Paul | B29 Education | $46.3M | 4 |
| COMMUNITYGIVING | St Cloud | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $46.2M | 6 |
| Governmental and Educational Assistance Corporation | Champlin | L200 Housing & Shelter | $46.2M | 15 |
| WEST SIDE COMMUNITY HEALTH SERVICES INC | St Paul | E30 Health Care | $46M | 11 |
| MINNESOTA MASTERPIECE HALL | Winona | A20 Arts, Culture & Humanities | $45.9M | 1 |
| MINNEAPOLIS COLLEGE OF ART AND DESIGN | Minneapolis | B430 Education | $45.8M | 9 |
| ST PAUL ACADEMY AND SUMMIT SCHOOL | Saint Paul | B200 Education | $45.8M | 7 |
| NU-WAY HOUSE INC | Minneapolis | — | $45.7M | 11 |
| ECUMEN SBC INC | Shoreview | — | $45.3M | 5 |
| MINNEAPOLIS JEWISH FEDERATION | Minneapolis | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $45.1M | 6 |
| STEELE-WASECA COOPERATIVE ELECTRIC | Owatonna | — | $45M | 16 |
| Ebenezer Society | Edina | E910 Health Care | $44.7M | 9 |
| CONSOLIDATED TELEPHONE COMPANY | Brainerd | — | $44.7M | 18 |
| Ruby's Heart | North Branch | X20 Religion-Related | $44.7M | 1 |
| FRASER | Richfield | P730 Human Services | $44.6M | 7 |
| AEON | Minneapolis | L20Z Housing & Shelter | $44.4M | 9 |
| GARDEN VALLEY TELEPHONE COMPANY DBA GARDEN VALLEY TECHNOLOGIES | Erskine | — | $44.3M | 16 |
| ALLINA HEALTH FOUNDATION | Minneapolis | E11 Health Care | $44.2M | 3 |
| AMERICAN ACADEMY OF NEUROLOGY | Minneapolis | S46 Community Improvement & Capacity Building | $44.1M | 17 |
| MOUNT OLIVET ROLLING ACRES INC | Victoria | P730 Human Services | $44.1M | 4 |
| Hammer Residences Inc | Wayzata | P700 Human Services | $44.1M | 8 |
| THE BUSH FOUNDATION | St Paul | B80 Education | $43.9M | 18 |
| INTERNATIONAL FALLS MEMORIAL HOSPITAL ASSOCIATION | International Falls | E22Z Health Care | $43.9M | 7 |
| ESSENTIA HEALTH MOOSE LAKE | Moose Lake | E20 Health Care | $43.8M | 14 |
| PAINTERS AND ALLIED TRADES DISTRICT COUNCIL 82 HEALTH CARE FUND | Bloomington | — | $43.7M | 7 |
| FEDERATED RURAL ELECTRIC | Jackson | — | $43.6M | 14 |
| HILL MUSEUM & MANUSCRIPT LIBRARY | Collegeville | B70 Education | $43.5M | 2 |
| GREATER TWIN CITIES UNITED WAY | Minneapolis | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $42.8M | 12 |
| SCHOLARSHIP AMERICA INC | Minneapolis | B820 Education | $42.8M | 0 |
| BETHESDA | Willmar | E91Z Health Care | $42.7M | 7 |
| THE FOUNDATION FOR HEALTH CARE CONTINUUMS | Sartell | E91 Health Care | $42.5M | 12 |
| BOREALIS PHILANTHROPY | Minneapolis | A99 Arts, Culture & Humanities | $42.5M | 8 |
| Think Small | Saint Paul | P33I Human Services | $41.9M | 5 |
| KATHERINE WELLS MACMILLAN FOUNDATION | Minneapolis | B82 Education | $41.8M | 0 |
| MINNEAPOLIS RETAIL MEAT CUTTERS AND FOOD HANDLERS HEALTH AND WELFARE FUND | Bloomington | — | $41.7M | 5 |
| LYNGBLOMSTEN CARE CENTER INC | St Paul | — | $41.4M | 8 |
| Community Action Partnership of Ramsey and Washington Counties | St Paul | — | $41.4M | 4 |
| CURA | Paynesville | L22 Housing & Shelter | $41.3M | 5 |
