| PLANNED PARENTHOOD MINNESOTA NORTH DAKOTA SOUTH DAKOTA | St Paul | E420 Health Care | $41.2M | 3 |
| AVIVO | Minneapolis | P110 Human Services | $41M | 6 |
| The Hormel Foundation | Austin | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $40.8M | 18 |
| BENEDICTINE LIVING COMMUNITIES INC | Minneapolis | — | $40.7M | 13 |
| NORTHWEST AREA FOUNDATION | St Paul | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $40.6M | 18 |
| GREATER MINNESOTA HOUSING FUND | St Paul | L20 Housing & Shelter | $40.3M | 8 |
| HEALTHPARTNERS RC | Bloomington | E22 Health Care | $40.2M | 14 |
| VOLUNTEERS OF AMERICA CARE FACILITIES | Eden Prairie | P750 Human Services | $39.6M | 15 |
| EDUCATION MINNESOTA | St Paul | J40 Employment | $39.1M | 14 |
| SERVICE MANAGEMENT GROUP INC | Minnetonka | P44 Human Services | $39M | 19 |
| HENNEPIN THEATRE TRUST | Minneapolis | A65 Arts, Culture & Humanities | $38.9M | 6 |
| VALLEY SENIOR SERVICE ALLIANCE | Roseville | P750 Human Services | $38.9M | 9 |
| AMERICAN ACADEMY OF NEUROLOGY INSTITUTE | Minneapolis | G030 Diseases, Disorders & Medical Disciplines | $38.8M | 9 |
| MINNESOTA ORCHESTRAL ASSOCIATION | Minneapolis | A690 Arts, Culture & Humanities | $38.7M | 8 |
| PRESBYTERIAN HOMES AND SERVICES | Roseville | — | $37.3M | 11 |
| CENTRACARE HEALTH SYSTEM - LONG PRAIRIE | Long Prairie | E21 Health Care | $37.2M | 16 |
| CERENITY SENIOR CARE | Minneapolis | E90Z Health Care | $37.1M | 10 |
| BETHANY LUTHERAN COLLEGE INC | Mankato | B410 Education | $37.1M | 4 |
| PEOPLE SERVING PEOPLE INC | Minneapolis | L410 Housing & Shelter | $36.7M | 7 |
| IHLE FAMILY FOUNDATION | St Paul | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $36.5M | 0 |
| JA WEDUM FOUNDATION | Plymouth | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $36.5M | 10 |
| VOANS SENIOR COMMUNITY CARE OF COLORADO INC | Eden Prairie | — | $36.4M | 11 |
| SHATTUCK-ST MARY'S SCHOOL | Faribault | B200 Education | $36.2M | 8 |
| SCIENCE MUSEUM OF MINNESOTA | St Paul | A560 Arts, Culture & Humanities | $36.1M | 10 |
| PROJECT FOR PRIDE IN LIVING INC | Minneapolis | P200 Human Services | $36.1M | 17 |
| GUTHRIE THEATER FOUNDATION | Minneapolis | A650 Arts, Culture & Humanities | $36.1M | 8 |
| WILD RICE ELECTRIC COOPERATIVE INC | Mahnomen | — | $35.8M | 17 |
| COMMUNITY REINVESTMENT FUND INC | Minneapolis | S310 Community Improvement & Capacity Building | $35.7M | 20 |
| North Central University | Minneapolis | B500 Education | $35.3M | 6 |
| ISD #535 HEALTH AND DENTAL CARE TRUST | Rochester | — | $35.2M | 3 |
| PRESBYTERIAN HOMES OF ARDEN HILLS INC | Roseville | P750 Human Services | $34.9M | 9 |
| UTILITY WORKERS UNION OF AMERICA NATIONAL HEALTH AND WELFARE FUND | Bloomington | Y43 Mutual & Membership Benefit | $34.9M | 3 |
| ACCESSIBLE SPACE INC | St Paul | P82Z Human Services | $34.8M | 6 |
| CHILDREN'S CLINIC NETWORK | Minneapolis | G98 Diseases, Disorders & Medical Disciplines | $34.6M | 10 |
| FIRST CARE MEDICAL SERVICES | Fosston | E22 Health Care | $34.6M | 10 |
| COLLEGE POSSIBLE INC | Saint Paul | B99 Education | $34.4M | 12 |
| MINNESOTA ODD FELLOWS HOME INC | Morris | L22 Housing & Shelter | $33.9M | 18 |
| RISE INCORPORATED | Fridley | J330 Employment | $33.8M | 7 |
| MENTAL HEALTH RESOURCES INC | St Paul | — | $33.7M | 9 |
| CENTER FOR ENERGY AND ENVIRONMENT | Minneapolis | C50 Environment | $33.7M | 11 |
| ELY-BLOOMENSON COMMUNITY HOSPITAL | Ely | E22Z Health Care | $33.6M | 7 |
| UNITED COMMUNITY ACTION PARTNERSHIP INC | Marshall | S20Z Community Improvement & Capacity Building | $33.6M | 5 |
| MDI COMMERCIAL SERVICES | Minneapolis | J20 Employment | $33.5M | 9 |
| RUNESTONE ELECTRIC ASSOCIATION | Alexandria | — | $33.4M | 14 |
| CROWN COLLEGE | St Bonifacius | — | $33.4M | 7 |
| XCEL ENERGY INC VEBA FOR RETIRED EMPLOYEES | Minneapolis | Y43 Mutual & Membership Benefit | $33.2M | 1 |
| LAND O'LAKES VENTURE37 | Arden Hills | Q31 International, Foreign Affairs & National Security | $33.1M | 6 |
| THE CENTER FOR VICTIMS OF TORTURE | Saint Paul | Q700 International, Foreign Affairs & National Security | $32.7M | 10 |
| Artspace Projects Inc | Minneapolis | A900 Arts, Culture & Humanities | $32.7M | 9 |
| HEARTLAND HEALTHCARE FUND | Bloomington | Y43 Mutual & Membership Benefit | $32.7M | 0 |
