| HAVERFORD SCHOOL | Haverford | B24Z Education | $55.5M | 12 |
| Fulton County Medical Center | Mc Connellsburg | E22Z Health Care | $55.4M | 9 |
| EAGLEVILLE HOSPITAL | Eagleville | E220 Health Care | $55.4M | 7 |
| UNITED CEREBRAL PALSY OF CENTRAL PENNSYLVANIA | Camp Hill | — | $55.3M | 5 |
| REA ENERGY COOPERATIVE INC | Indiana | — | $55.3M | 15 |
| THE BEHAVIORAL WELLNESS CENTER AT GIRARD | Philadelphia | E210 Health Care | $55.2M | 13 |
| UFCW 1776 & PARTICIPATING EMPLOYERS HEALTH & WELFARE FUND | Plymouth Meeting | — | $55.2M | 0 |
| PITTSBURGH SYMPHONY INC | Pittsburgh | A690 Arts, Culture & Humanities | $55.2M | 10 |
| IMMACULATA UNIVERSITY | Immaculata | B430 Education | $55.2M | 11 |
| THE FUND FOR CHARITABLE GIVING | Pittsburgh | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $55M | 1 |
| COMMISSION ON ECONOMIC OPPORTUNITY OF LUZERNE COUNTY | Wilkesbarre | L80Z Housing & Shelter | $54.9M | 2 |
| BRETHREN VILLAGE | Lititz | P750 Human Services | $54.8M | 7 |
| EVERY CURE INC | Philadelphia | H99 Medical Research | $54.5M | 6 |
| SERVICE EMPLOYEES INTL UNION LOC 32BJ D 36 BUILDING OPERATORS WELFARE TRUST FD | Philadelphia | — | $54.5M | 8 |
| GATEWAY REHABILITATION CENTER | Moon Township | F220 Mental Health & Crisis Intervention | $54.3M | 13 |
| MANN CENTER FOR THE PERFORMING ARTS | Philadelphia | A610 Arts, Culture & Humanities | $53.8M | 6 |
| INVISION CUSTOMIZED SERVICES | Wexford | P70Z Human Services | $53.8M | 8 |
| FAMILY CARE CENTERS INC | Allentown | — | $53.6M | 25 |
| WILLIAM PENN CHARTER SCHOOL INC | Philadelphia | B200 Education | $53.5M | 12 |
| ECOG-ACRIN MEDICAL RESEARCH FOUNDATION INC | Philadelphia | G05 Diseases, Disorders & Medical Disciplines | $53.3M | 5 |
| THE HILL SCHOOL | Pottstown | B250 Education | $53.3M | 10 |
| CHILDREN'S HOSPITAL OF PITTSBURGH FOUNDATION | Pittsburgh | E11 Health Care | $53.2M | 7 |
| MILLCREEK MANOR | Erie | E91Z Health Care | $53M | 9 |
| American Association for Cancer Research Foundation | Philadelphia | G30 Diseases, Disorders & Medical Disciplines | $52.9M | 8 |
| THIEL COLLEGE | Greenville | B420 Education | $52.7M | 11 |
| GEISINGER COMMONWEALTH SCH OF MED | Danville | B500 Education | $52.7M | 15 |
| CEDAR CREST COLLEGE | Allentown | B420 Education | $52.5M | 13 |
| GARDEN SPOT VILLAGE | New Holland | P750 Human Services | $52.3M | 9 |
| HR PHYSICIAN SERVICES | Huntingdon Valley | E60 Health Care | $52.2M | 11 |
| CONCORDIA VISITING NURSES | Cabot | E92 Health Care | $52.2M | 8 |
| SHADY SIDE ACADEMY | Pittsburgh | B200 Education | $52M | 10 |
| BEAUMONT RETIREMENT SERVICES INC | Bryn Mawr | P750 Human Services | $51.9M | 9 |
| DELAWARE VALLEY COMMUNITY HEALTH INC | Philadelphia | — | $51.9M | 10 |
| UFCW LOCAL 1776KS WESTERN DIVISION AND EMPLOYERS' HEALTH FUND | Canonsburg | — | $51.9M | 0 |
| PATHWAYS OF SOUTHWESTERN PENNSYLVANIA INC | Washington | P82 Human Services | $51.5M | 6 |
| VALLEY YOUTH HOUSE COMMITTEE INC | Bethlehem | P300 Human Services | $51.3M | 5 |
| CHESTNUT HILL COLLEGE | Philadelphia | B430 Education | $51.2M | 7 |
| THE FRANKLIN INSTITUTE | Philadelphia | A25 Arts, Culture & Humanities | $51.2M | 14 |
| HEAVY & HIGHWAY CONSTRUCTION HEALTH AND WELFARE FUND | Philadelphia | — | $51.1M | 1 |
| THE MENNONITE HOME | Lancaster | P750 Human Services | $51.1M | 10 |
| GENEVA COLLEGE | Beaver Falls | B420 Education | $51M | 8 |
| CENTRAL ELECTRIC COOPERATIVE INC | Parker | — | $50.9M | 16 |
| PROJECT HOME | Philadelphia | P850 Human Services | $50.7M | 9 |
| WILLIAM PENN ASSOCIATION | Pittsburgh | — | $50.6M | 13 |
| BEHAVIORAL HEALTH OF CAMBRIA COUNTY | Johnstown | E60 Health Care | $50.2M | 2 |
| PENNSYLVANIA LEGAL AID NETWORK INC FKA/ PENNSYLVANIA LEGAL SERVICES | Harrisburg | I80Z Crime & Legal-Related | $50.2M | 2 |
| GEISINGER JERSEY SHORE HOSPITAL | Danville | E22Z Health Care | $50.2M | 16 |
| MEADOWOOD CORPORATION | Worcester | P750 Human Services | $50.2M | 7 |
| VALLEY HEALTH PARTNERS COMMUNITY HEALTH CENTER | Allentown | E32 Health Care | $50.1M | 10 |
| WHITEMARSH CONTINUING CARE RETIREMENT COMMUNITY | Lafayette Hill | L220 Housing & Shelter | $50.1M | 9 |
