| RAVE FINANCIAL CREDIT UNION | Beaumont | W61 Public & Societal Benefit | $62.2M | 16 |
| KATE MARMION CHARITABLE FOUNDATION | San Antonio | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $62.1M | 3 |
| MANNED SPACE FLIGHT EDUCATION FOUNDATION INC | Houston | S300 Community Improvement & Capacity Building | $61.8M | 13 |
| VELOCITY CREDIT UNION | Austin | — | $61.7M | 16 |
| WESTMINSTER MANOR | Austin | E91Z Health Care | $61.5M | 5 |
| EAGLE'S TRACE INC | Houston | L22 Housing & Shelter | $61.4M | 9 |
| East Texas Baptist University | Marshall | B430 Education | $61.3M | 8 |
| Schreiner University | Kerrville | B420 Education | $61M | 10 |
| CONCORDIA UNIVERSITY TEXAS | Austin | B430 Education | $60.9M | 18 |
| YOUNG WOMEN'S CHRISTIAN ASSOCIATION EL PASO DEL NORTE REGION | El Paso | P27Z Human Services | $60.7M | 3 |
| Wayland Baptist University | Plainview | B420 Education | $60.6M | 12 |
| BURKE CENTER | Lufkin | P82Z Human Services | $60.5M | 11 |
| TEXAS PIPE TRADES HEALTH BENEFIT PLAN | Houston | — | $60.2M | 0 |
| Interfaith Ministries for Greater Houston | Houston | — | $59.9M | 7 |
| HEALTH EDUCATION LEARNING PROJECT | Fort Worth | A20 Arts, Culture & Humanities | $59M | 4 |
| NAVASOTA VALLEY ELECTRIC COOPERATIVE INC | Franklin | — | $58.9M | 17 |
| Hensel Phelps Construction Co Employee Benefit Trust | Dallas | Y43 Mutual & Membership Benefit | $58.4M | 1 |
| ZORICH FAMILY FOUNDATION | Houston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $58.4M | 0 |
| HOCKADAY SCHOOL | Dallas | B200 Education | $58.3M | 8 |
| DALLAS PHYSICIAN MEDICAL SERVICES FOR CHILDREN INC | Dallas | E20 Health Care | $57.7M | 12 |
| Summer Institute of Linguistics Inc dba SIL Global | Dallas | Q200 International, Foreign Affairs & National Security | $57.7M | 13 |
| Conflict and Development Foundation | Castroville | Q05 International, Foreign Affairs & National Security | $57.5M | 2 |
| SJRC TEXAS INC | Bulverde | P70Z Human Services | $57M | 13 |
| INTOUCH CREDIT UNION | Plano | — | $57M | 15 |
| MEMORIAL MEDICAL CENTER - LIVINGSTON | Lufkin | E21 Health Care | $56.3M | 13 |
| BUCKNER FOUNDATION INC | Dallas | P12 Human Services | $56.1M | 8 |
| THE GEORGE W BUSH FOUNDATION | Dallas | B70 Education | $56M | 11 |
| Driscoll Healthcare Services | Corpus Christi | E62 Health Care | $55.6M | 13 |
| ST MARK'S SCHOOL OF TEXAS | Dallas | B200 Education | $55.6M | 9 |
| The Center for the Performing Arts at the Woodlands | The Woodlands | A60B Arts, Culture & Humanities | $55.2M | 6 |
| McMurry University | Abilene | B420 Education | $55.2M | 14 |
| FEEDING TEXAS | Austin | S50Z Community Improvement & Capacity Building | $54.7M | 7 |
| UNITED WAY OF METROPOLITAN DALLAS INC | Dallas | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $54.7M | 12 |
| Aqua Water Supply Corporation | Bastrop | — | $54M | 16 |
| C C YOUNG MEMORIAL HOME | Dallas | E910 Health Care | $54M | 10 |
| TEXAS PREGNANCY CARE NETWORK | Austin | P20 Human Services | $53.7M | 3 |
| COOKE COUNTY ELECTRIC COOPERATIVE ASSOCIATION | Muenster | — | $53.6M | 16 |
| AGREEMENT OF TRUST FOR THE MARITIME ASSOC - ILA WELFARE & VACATION | Houston | J40 Employment | $53.6M | 3 |
| ALLIANCE CREDIT UNION | Lubbock | — | $53.6M | 21 |
| Texas Health Harris Methodist Hospital Azle | Azle | E22 Health Care | $53.5M | 17 |
| Comanche County Medical Center Company | Comanche | E22 Health Care | $53.5M | 7 |
| Kimbell Art Foundation | Fort Worth | A20O Arts, Culture & Humanities | $53.2M | 2 |
| TMF HEALTH QUALITY INSTITUTE | Austin | E05 Health Care | $53.2M | 27 |
| DIAN GRAVES OWEN FOUNDATION | Abilene | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $53M | 2 |
| COMPASS ROSE EDUCATION INC | San Antonio | B12 Education | $52.9M | 7 |
| THE FORT WORTH ZOOLOGICAL ASSOCIATION | Fort Worth | D500 Animal-Related | $52.8M | 8 |
| BAITULMAAL INC | Irving | Q33 International, Foreign Affairs & National Security | $52.8M | 1 |
| Brazos Higher Education Authority Inc | Waco | B82 Education | $52.8M | 7 |
| HOUSTON COUNTY ELECTRIC COOPERATIVE INC | Crockett | — | $52.6M | 12 |
| THE CUMBERLAND REST INC | Fort Worth | P75 Human Services | $52.5M | 6 |
