| Hensel Phelps Construction Co | Dallas | Y43 Mutual & Membership Benefit | $58.4M | 1 |
| ZORICH FAMILY FOUNDATION | Houston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $58.4M | 0 |
| HOCKADAY SCHOOL | Dallas | B200 Education | $58.3M | 8 |
| THE KARAKIN FOUNDATION | Abilene | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $58M | 5 |
| Southwest Arkansas Electric Cooperative Corp | Texarkana | — | $57.9M | 21 |
| DALLAS PHYSICIAN MEDICAL SERVICES FOR CHILDREN INC | Dallas | E20 Health Care | $57.7M | 12 |
| Summer Institute of Linguistics Inc | Dallas | Q200 International, Foreign Affairs & National Security | $57.7M | 13 |
| Conflict and Development Foundation | Castroville | Q05 International, Foreign Affairs & National Security | $57.5M | 2 |
| BASIS TEXAS CHARTER SCHOOLS INC | San Antonio | B29 Education | $57.5M | 2 |
| Baylor Health Care System Foundation | Dallas | E12 Health Care | $57.3M | 12 |
| Hillcrest Physician Services | Dallas | E320 Health Care | $57.2M | 16 |
| INTOUCH CREDIT UNION | Plano | — | $57M | 15 |
| BUCKNER FOUNDATION INC | Dallas | P12 Human Services | $56.1M | 8 |
| COMMUNITY RESOURCE CREDIT UNION | Baytown | — | $56M | 12 |
| TMF HEALTH QUALITY INSTITUTE | Austin | E05 Health Care | $55.9M | 29 |
| Driscoll Healthcare Services | Corpus Christi | E62 Health Care | $55.6M | 13 |
| ST MARK'S SCHOOL OF TEXAS | Dallas | B200 Education | $55.6M | 9 |
| The Center for the Performing Arts at | The Woodlands | A60B Arts, Culture & Humanities | $55.2M | 6 |
| EAGLE'S TRACE INC | Houston | L22 Housing & Shelter | $55.2M | 8 |
| BAITULMAAL INC | Irving | Q33 International, Foreign Affairs & National Security | $55.2M | 1 |
| McMurry University | Abilene | B420 Education | $55.2M | 14 |
| MEMORIAL MEDICAL CENTER - LIVINGSTON | Lufkin | E21 Health Care | $55M | 10 |
| AMERICAN QUARTER HORSE ASSOCIATION | Amarillo | — | $54.9M | 22 |
| FEEDING TEXAS | Austin | S50Z Community Improvement & Capacity Building | $54.7M | 7 |
| Aqua Water Supply Corporation | Bastrop | — | $54M | 16 |
| C C YOUNG MEMORIAL HOME | Dallas | E910 Health Care | $54M | 10 |
| North Texas Higher Education Authority Inc | Arlington | B80Z Education | $53.8M | 0 |
| TEXAS PREGNANCY CARE NETWORK | Austin | P20 Human Services | $53.7M | 3 |
| COOKE COUNTY ELECTRIC COOPERATIVE | Muenster | — | $53.6M | 16 |
| Scott & White Hospital Brenham | Dallas | E220 Health Care | $53.6M | 12 |
| AGREEMENT OF TRUST FOR THE MARITIME | Houston | J40 Employment | $53.6M | 3 |
| Texas Health Harris Methodist Hospital Azle | Azle | E22 Health Care | $53.5M | 17 |
| Comanche County Medical Center Company | Comanche | E22 Health Care | $53.5M | 7 |
| REWILD | Austin | D30 Animal-Related | $53.3M | 8 |
| LUBBOCK CHRISTIAN UNIVERSITY | Lubbock | B420 Education | $53.3M | 8 |
| Kimbell Art Foundation | Fort Worth | A20O Arts, Culture & Humanities | $53.2M | 2 |
| DIAN GRAVES OWEN FOUNDATION | Abilene | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $53M | 2 |
| COMPASS ROSE EDUCATION INC | San Antonio | B12 Education | $52.9M | 7 |
| THE FORT WORTH ZOOLOGICAL ASSOCIATION | Fort Worth | D500 Animal-Related | $52.8M | 8 |
| HOUSTON COUNTY ELECTRIC COOPERATIVE INC | Crockett | — | $52.6M | 12 |
| THE CUMBERLAND REST INC | Fort Worth | P75 Human Services | $52.5M | 6 |
| Art Bridges Inc | Fort Worth | A25 Arts, Culture & Humanities | $52.3M | 2 |
| Goodwill Industries of Fort Worth Inc | Fort Worth | J32Z Employment | $52.3M | 9 |
| P16 Plus Council of Greater Bexar County Foundation Inc | San Antonio | B90 Education | $52.1M | 1 |
| PRESBYTERIAN VILLAGE NORTH FOREFRONT | Dallas | L22 Housing & Shelter | $52M | 9 |
| STEPHEN F AUSTIN COMMUNITY HEALTH CENTER | Alvin | E20 Health Care | $52M | 46 |
| CONCHO VALLEY ELECTRIC COOPERATIVE INC | San Angelo | — | $51.6M | 14 |
| WORK SERVICES CORPORATION | Wichita Falls | J330 Employment | $51.6M | 7 |
| Rural Capital Area Workforce Development Board | Cedar Park | J220 Employment | $51.5M | 11 |
| Houston Parks Board | Houston | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $51.4M | 12 |
