| AVOCADOS FROM MEXICO | Irving | S46 Community Improvement & Capacity Building | $69.5M | 5 |
| UNITED WAY OF METROPOLITAN DALLAS INC | Dallas | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $68.9M | 12 |
| THE UNIVERSITY OF TEXAS FOUNDATION INC | Austin | — | $68.5M | 1 |
| Create Healthy Management | Fredericksburg | E220 Health Care | $68.4M | 7 |
| CONCORDIA UNIVERSITY TEXAS | Austin | B430 Education | $68.4M | 13 |
| ALLIANCE TO END PLASTIC WASTE INC | Austin | C01 Environment | $68.3M | 12 |
| FORT WORTH COMMUNITY CREDIT UNION | Bedford | — | $68.3M | 23 |
| TESSITURA NETWORK INC | Dallas | — | $67.9M | 10 |
| KINDER FOUNDATION | Houston | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $67.6M | 7 |
| FirstDay Foundation | San Antonio | P30 Human Services | $67.5M | 12 |
| Dallas Theological Seminary | Dallas | B500 Education | $67.2M | 13 |
| AVANCE INC | San Antonio | S20Z Community Improvement & Capacity Building | $67.1M | 13 |
| Allied Pilots Association | Fort Worth | — | $66.5M | 55 |
| Cherokee County Electric Cooperative | Rusk | — | $66.5M | 14 |
| SOUTH PLAINS COMMUNITY ACTION ASSOC | Levelland | P200 Human Services | $66.4M | 5 |
| Sunny Glen Children's Home Inc | San Benito | P70Z Human Services | $66.4M | 6 |
| HIGHLAND SPRINGS INC | Dallas | L22 Housing & Shelter | $66.3M | 7 |
| THE MENNINGER CLINIC | Houston | E300 Health Care | $66.3M | 11 |
| Texas Health Harris Methodist Hospital | Stephenville | E220 Health Care | $65.6M | 16 |
| Brazos Higher Education Authority Inc | Waco | B82 Education | $65.6M | 7 |
| TRINITY CHRISTIAN CENTER | Fort Worth | X200 Religion-Related | $65.5M | 10 |
| CLAYMOORE NORTHWEST INC | Dallas | — | $65.4M | 0 |
| TEXAS LUTHERAN UNIVERSITY | Seguin | — | $65M | 14 |
| The Awty International School | Houston | — | $64.7M | 10 |
| The Philecology Foundation | Fort Worth | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $64.3M | 0 |
| TRANSPORT WORKERS MTA HEALTH & WELF | Houston | — | $63.9M | 0 |
| WARREN CHARITABLE FOUNDATION | Midland | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $63.8M | 0 |
| SAN ANTONIO ZOOLOGICAL SOCIETY | San Antonio | D500 Animal-Related | $63.8M | 10 |
| Rusk County Electric Cooperative Inc | Henderson | — | $63.3M | 14 |
| St Hope Foundation Inc | Houston | P200 Human Services | $63.3M | 9 |
| YOUNG WOMEN'S CHRISTIAN ASSOCIATION | El Paso | P27Z Human Services | $62.9M | 5 |
| CIRCUIT EVENTS LOCAL ORGANIZING | Austin | S40 Community Improvement & Capacity Building | $62.9M | 0 |
| JASPER NEWTON ELECTRIC COOPERATIVE INC | Kirbyville | — | $62.7M | 17 |
| OneShare Health LLC | Irving | — | $62.5M | 15 |
| METHODIST CHILDREN'S HOME | Waco | P730 Human Services | $62.3M | 10 |
| MOODY GARDENS INC | Galveston | — | $62.2M | 7 |
| RAVE FINANCIAL CREDIT UNION | Beaumont | W61 Public & Societal Benefit | $62.2M | 16 |
| Baylor Health Care System | Dallas | E210 Health Care | $61.9M | 5 |
| MANNED SPACE FLIGHT EDUCATION | Houston | S300 Community Improvement & Capacity Building | $61.8M | 13 |
| VELOCITY CREDIT UNION | Austin | — | $61.7M | 16 |
| East Texas Baptist University | Marshall | B430 Education | $61.3M | 8 |
| Regional East Texas Food Bank | Tyler | — | $61.1M | 2 |
| Schreiner University | Kerrville | B420 Education | $61M | 10 |
| NAVASOTA VALLEY ELECTRIC | Franklin | — | $61M | 17 |
| BURKE CENTER | Lufkin | P82Z Human Services | $60.5M | 11 |
| Interfaith Ministries for Greater | Houston | — | $59.9M | 7 |
| TEXAS BAY CREDIT UNION | Houston | — | $59.3M | 17 |
| HEALTH EDUCATION LEARNING PROJECT | Fort Worth | A20 Arts, Culture & Humanities | $59M | 4 |
| FIVEPOINT CREDIT UNION | Nederland | — | $58.8M | 17 |
| WAYLAND BAPTIST UNIVERSITY | Plainview | B420 Education | $58.5M | 7 |
