| TEXELL CREDIT UNION | Temple | — | $51.3M | 19 |
| LLOYD'S REGISTER NORTH AMERICA INC | Houston | S410 Community Improvement & Capacity Building | $51M | 20 |
| RESOURCE ONE CREDIT UNION | Dallas | — | $50.9M | 20 |
| TEXAS RIOGRANDE LEGAL AID INC | Mercedes | I80 Crime & Legal-Related | $50.7M | 9 |
| Crossroads Housing Development Corp | Big Spring | L20 Housing & Shelter | $50.7M | 2 |
| South Texas College of Law Houston Inc | Houston | B500 Education | $50.4M | 29 |
| Texas Heart Institute | Houston | H430 Medical Research | $50.2M | 11 |
| AMERICA CAN | Dallas | B61Z Education | $50M | 7 |
| SAN ANTONIO LIVESTOCK EXPOSITION INC | San Antonio | N520 Recreation & Sports | $49.7M | 9 |
| SOUTH TEXAS FOOD BANK | Laredo | S50Z Community Improvement & Capacity Building | $49.4M | 1 |
| PHILLIPS FAMILY FOUNDATION | Houston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $49.1M | 0 |
| JUNE SHELTON SCHOOL AND EVALUATION | Dallas | B28 Education | $49M | 9 |
| CAL FARLEY'S BOYS RANCH | Amarillo | P730 Human Services | $48.8M | 8 |
| Texas Health Presbyterian Hospital Kaufman | Kaufman | E22 Health Care | $48.8M | 20 |
| Memorial Hermann Foundation | Houston | E110 Health Care | $48.7M | 5 |
| COMANCHE COUNTY ELECTRIC COOPERATIVE | Comanche | — | $48.6M | 14 |
| ST JOSEPH PHYSICIAN ASSOCIATES | Bryan | E21 Health Care | $48.6M | 23 |
| TEXAS ASSOCIATION OF COUNTY OFFICIALS | Austin | — | $48.5M | 15 |
| THE GEORGE W BUSH FOUNDATION | Dallas | B70 Education | $48.5M | 11 |
| The John Cooper School | The Woodlands | — | $48.3M | 7 |
| BELLSOUTH CORP RFA (LIFE) VEBA TRUST | Dallas | — | $48M | 1 |
| METHODIST HOSPITAL SELF-INSURANCE TRUST | Houston | Y200 Mutual & Membership Benefit | $47.8M | 0 |
| UNITED WAY OF SAN ANTONIO AND BEXAR | San Antonio | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $47.8M | 8 |
| Hillcrest Family Health Center | Dallas | E32Z Health Care | $47.7M | 19 |
| PARISH EPISCOPAL SCHOOL | Dallas | — | $47.6M | 10 |
| BARTLETT ELECTRIC COOPERATIVE INC | Bartlett | — | $47.6M | 21 |
| The Lanier Theological Library Foundation | Houston | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $47.4M | 1 |
| BUCKNER INTERNATIONAL | Dallas | P80 Human Services | $47.3M | 13 |
| DALLAS COLLEGE FOUNDATION INC | Dallas | B41I Education | $47.3M | 2 |
| Houston Country Club | Houston | — | $47.2M | 12 |
| JAMES N MCCOY FOUNDATION | Wichita Falls | T21J Philanthropy, Voluntarism & Grantmaking Foundations | $46.9M | 4 |
| READYONE INDUSTRIES INC | El Paso | J30Z Employment | $46.9M | 17 |
| THE LINBECK FAMILY CHARITABLE TRUST | Houston | S11 Community Improvement & Capacity Building | $46.8M | 2 |
| FORT WORTH COUNTRY DAY SCHOOL INC | Fort Worth | B200 Education | $46.8M | 7 |
| Tri-County Behavioral Healthcare | Conroe | — | $46.5M | 11 |
| SMART FINANCIAL CREDIT UNION | Houston | — | $46.4M | 21 |
| Central Missionary Clearinghouse Inc | Houston | — | $46.3M | 2 |
| THE EPISCOPAL SCHOOL OF DALLAS INC | Dallas | — | $46.2M | 9 |
| MORNINGSIDE MINISTRIES | San Antonio | P750 Human Services | $46.1M | 8 |
| NORTH ALAMO WATER SUPPLY CORPORATION | Edinburg | — | $45.8M | 13 |
| BRAZOS VALLEY SCHOOLS CREDIT UNION | Katy | — | $45.5M | 7 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF | Austin | P27Z Human Services | $45.4M | 14 |
| HARRY BASS FOUNDATION | Dallas | — | $45.4M | 2 |
| MEMBERS CHOICE CREDIT UNION | Houston | — | $45.4M | 19 |
| BioBridge Global | San Antonio | E026 Health Care | $45.3M | 15 |
| CATHOLIC CHARITIES OF DALLAS INC | Dallas | — | $45.3M | 7 |
| TLCA | San Angelo | B20 Education | $45.2M | 3 |
| THE MULVA FAMILY FOUNDATION | Austin | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $45.1M | 0 |
| GOODWILL INDUSTRIES OF SAN ANTONIO CONTRACT | San Antonio | P20 Human Services | $44.9M | 9 |
| ANESTHESIOLOGISTS FOR CHILDREN | Dallas | — | $44.8M | 7 |
