| Art Bridges Inc | Fort Worth | A25 Arts, Culture & Humanities | $52.3M | 2 |
| Goodwill Industries of Fort Worth Inc | Fort Worth | J32Z Employment | $52.3M | 9 |
| P16 Plus Council of Greater Bexar County Foundation Inc | San Antonio | B90 Education | $52.1M | 1 |
| PRESBYTERIAN VILLAGE NORTH FOREFRONT LIVING | Dallas | L22 Housing & Shelter | $52M | 9 |
| STEPHEN F AUSTIN COMMUNITY HEALTH CENTER | Alvin | E20 Health Care | $52M | 46 |
| FOOD BANK OF THE RIO GRANDE VALLEY INC | McAllen | — | $51.8M | 2 |
| CHRISTUS HEALTH PLAN LOUISIANA | Irving | — | $51.6M | 15 |
| CONCHO VALLEY ELECTRIC COOPERATIVE INC | San Angelo | — | $51.6M | 14 |
| WORK SERVICES CORPORATION | Wichita Falls | J330 Employment | $51.6M | 7 |
| Scott & White Hospital Brenham | Dallas | E220 Health Care | $51.5M | 13 |
| Rural Capital Area Workforce Development Board | Cedar Park | J220 Employment | $51.5M | 11 |
| Houston Parks Board | Houston | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $51.4M | 12 |
| THIRD FUTURE SCHOOLS- TEXAS | Austin | B20 Education | $51.3M | 0 |
| TEXELL CREDIT UNION | Temple | — | $51.3M | 19 |
| FORT WORTH COUNTRY DAY SCHOOL INC | Fort Worth | B200 Education | $51.3M | 7 |
| RESOURCE ONE CREDIT UNION | Dallas | — | $50.9M | 20 |
| TOYOTA MOTOR SALES USA INC POST-RETIREMENT MEDICAL TRUST | Plano | Y43 Mutual & Membership Benefit | $50.8M | 1 |
| THE EPISCOPAL SCHOOL OF DALLAS INC | Dallas | — | $50.8M | 9 |
| TEXAS RIOGRANDE LEGAL AID INC | Mercedes | I80 Crime & Legal-Related | $50.7M | 9 |
| Crossroads Housing Development Corp | Big Spring | L20 Housing & Shelter | $50.7M | 2 |
| OneShare Health LLC | Irving | E19 Health Care | $50.6M | 14 |
| South Texas College of Law Houston Inc | Houston | B500 Education | $50.4M | 29 |
| Texas Heart Institute | Houston | H430 Medical Research | $50.2M | 11 |
| FOUNDATION COMMUNITIES INC | Austin | L20Z Housing & Shelter | $50M | 14 |
| BRAZOS VALLEY SCHOOLS CREDIT UNION | Katy | — | $50M | 7 |
| Hope Media Group | Humble | A340 Arts, Culture & Humanities | $50M | 8 |
| The Cynthia & George Mitchell Foundation | The Woodlands | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $50M | 10 |
| CONFERENCE USA | Dallas | N41Z Recreation & Sports | $49.9M | 13 |
| TLCA TEXAS LEADERSHIP CHARTER ACADEMY | San Angelo | B20 Education | $49.8M | 4 |
| UNITED STATES BOWLING CONGRESS INC | Arlington | N70 Recreation & Sports | $49.8M | 9 |
| SAN ANTONIO LIVESTOCK EXPOSITION INC | San Antonio | N520 Recreation & Sports | $49.7M | 9 |
| Dallas Seminary Foundation | Dallas | B115 Education | $49.6M | 8 |
| SOUTH TEXAS FOOD BANK | Laredo | S50Z Community Improvement & Capacity Building | $49.4M | 1 |
| St Hope Foundation Inc | Houston | P200 Human Services | $49.2M | 9 |
| PHILLIPS FAMILY FOUNDATION | Houston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $49.1M | 0 |
| JUNE SHELTON SCHOOL AND EVALUATION CENTER | Dallas | B28 Education | $49M | 9 |
| CAL FARLEY'S BOYS RANCH | Amarillo | P730 Human Services | $48.8M | 8 |
| Texas Health Presbyterian Hospital Kaufman | Kaufman | E22 Health Care | $48.8M | 20 |
| Hillcrest Family Health Center | Dallas | E32Z Health Care | $48.7M | 20 |
| COMANCHE COUNTY ELECTRIC COOPERATIVE ASSOCIATION | Comanche | — | $48.6M | 14 |
| TEXAS ASSOCIATION OF COUNTY OFFICIALS | Austin | — | $48.5M | 15 |
| SOUTHWEST AIRLINES PILOTS ASSOCIATION | Irving | — | $48.4M | 10 |
| The John Cooper School | The Woodlands | — | $48.3M | 7 |
| GOODWILL INDUSTRIES OF SAN ANTONIO CONTRACT SERVICES | San Antonio | P20 Human Services | $48.3M | 10 |
| BELLSOUTH CORP RFA (LIFE) VEBA TRUST FOR REP EE'S | Dallas | — | $48M | 1 |
| UNION SQUARE CREDIT UNION | Wichita Falls | — | $48M | 17 |
| SMART FINANCIAL CREDIT UNION | Houston | — | $47.9M | 21 |
| METHODIST HOSPITAL SELF-INSURANCE TRUST | Houston | Y200 Mutual & Membership Benefit | $47.8M | 0 |
| UNITED WAY OF SAN ANTONIO AND BEXAR COUNTY | San Antonio | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $47.8M | 8 |
| PARISH EPISCOPAL SCHOOL | Dallas | — | $47.6M | 10 |
