| AMERICAN UNIVERSITY OF BEIRUT | New York | B43Z Education | $571.8M | 31 |
| CROUSE HEALTH HOSPITAL INC | Syracuse | E220 Health Care | $564M | 13 |
| NEW YORK HOTEL TRADES COUNCIL AND HOTEL ASSOC OF NYC INC HEALTH BENEFITS FUND | New York | — | $562M | 17 |
| HIGHLAND HOSPITAL OF ROCHESTER | Rochester | E220 Health Care | $547.3M | 14 |
| PENSION COMM JOINT INDUSTRY BOARD OF THE ELECTRICAL INDUSTRY | Flushing | — | $525.4M | 0 |
| MARINA KELLEN FRENCH FOUNDATION INC | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $514.1M | 0 |
| THE BROOKLYN HOSPITAL CENTER | Brooklyn | E220 Health Care | $506.1M | 19 |
| THE MICHAEL J FOX FOUNDATION FOR PARKINSON'S RESEARCH | New York | H48 Medical Research | $505.3M | 11 |
| THE ROCKEFELLER UNIVERSITY | New York | B430 Education | $501M | 20 |
| Our Lady of Lourdes Memorial Hospital Inc | Binghamton | E22 Health Care | $488.9M | 14 |
| MVHS INC | Utica | E22 Health Care | $485.8M | 11 |
| UNITED JEWISH APPEAL-FEDERATION OF JEWISH PHILANTHROPIES OF NEW YORK INC | New York | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $484.3M | 14 |
| Mercy Hospital of Buffalo | Buffalo | E220 Health Care | $480.2M | 21 |
| SAMARITAN HOSPITAL | Troy | E220 Health Care | $474.2M | 16 |
| NOVO FOUNDATION | Hurley | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $473.6M | 4 |
| Sisters of Charity Hospital | Buffalo | E220 Health Care | $470.9M | 24 |
| FUND FOR POLICY REFORM INC | New York | W05 Public & Societal Benefit | $470.1M | 9 |
| CHAMPLAIN VALLEY PHYSICIANS HOSPITAL MEDICAL CENTER | Plattsburgh | E220 Health Care | $469.8M | 16 |
| UNITED STATES TENNIS ASSOCIATION INCORPORATED | Purchase | — | $468.6M | 26 |
| LONG ISLAND UNIVERSITY | Brookville | — | $466.5M | 19 |
| UNITED ISRAEL APPEAL INC | New York | Q710 International, Foreign Affairs & National Security | $464.8M | 2 |
| RICHMOND MEDICAL CENTER | Staten Island | E20 Health Care | $461.1M | 19 |
| ARNOT OGDEN MEDICAL CENTER | Elmira | E220 Health Care | $457.1M | 12 |
| Success Academy Charter Schools - NYC | New York | B29 Education | $452.6M | 5 |
| THE AMERICAN SOCIETY FOR THE PREVENTION OF CRUELTY TO ANIMALS | New York | D200 Animal-Related | $446.1M | 14 |
| PHELPS MEMORIAL HOSPITAL ASSOCIATION C/O NORTHWELL HEALTH INC | Westbury | E220 Health Care | $445M | 19 |
| ELLIS HOSPITAL D/B/A ELLIS MEDICINE | Schenectady | E220 Health Care | $444.3M | 10 |
| EPISCOPAL HEALTH SERVICES INC | Garden City | E210 Health Care | $441.2M | 15 |
| John T Mather Memorial Hospital C/O NORTHWELL HEALTH INC | Westbury | E220 Health Care | $436.7M | 20 |
| OPEN SOCIETY INSTITUTE | New York | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $436.3M | 12 |
| UNITED FEDERATION OF TEACHERS WELFARE FUND | New York | — | $435.8M | 11 |
| FLUSHING HOSPITAL MEDICAL CENTER | Flushing | E220 Health Care | $426.2M | 8 |
| CAYUGA MEDICAL CENTER AT ITHACA | Ithaca | E220 Health Care | $426.2M | 21 |
| North Shore-LIJ Anesthesiology PC | Westbury | E60 Health Care | $424.3M | 13 |
| HUDSON VALLEY CREDIT UNION | Poughkeepsie | W61 Public & Societal Benefit | $424.1M | 15 |
| STONY BROOK FOUNDATION INC | Stony Brook | B112 Education | $421M | 9 |
| NYC DISTRICT COUNCIL OF CARPENTERS WELFARE FUND | New York | — | $416.1M | 7 |
| THE LEGAL AID SOCIETY | New York | I800 Crime & Legal-Related | $415.8M | 13 |
| The American Jewish Joint Distribution Committee Inc | New York | Q330 International, Foreign Affairs & National Security | $412.9M | 16 |
| IATSE NATIONAL HEALTH AND WELFARE FUND | New York | — | $412.6M | 6 |
| Albert Einstein College of Medicine | Bronx | B50 Education | $411.4M | 12 |
| COLGATE UNIVERSITY | Hamilton | B42Z Education | $407.3M | 18 |
| WYCKOFF HEIGHTS MEDICAL CENTER | Brooklyn | E21 Health Care | $406.3M | 13 |
| HAMASPIK CHOICE INC | Spring Valley | E92 Health Care | $406.2M | 16 |
| PRATT INSTITUTE | Brooklyn | B430 Education | $398.1M | 14 |
| THE NEW YORK PUBLIC LIBRARY ASTOR LENOX AND TILDEN FOUNDATIONS | New York | B700 Education | $397.1M | 25 |
| INSTITUTE OF INTERNATIONAL EDUCATION INC | New York | Q220 International, Foreign Affairs & National Security | $395.5M | 11 |
| YESHIVA UNIVERSITY | New York | B430 Education | $394.2M | 15 |
| Montefiore Health System Inc | Tarrytown | E19 Health Care | $393.4M | 9 |
| PLANNED PARENTHOOD FEDERATION OF AMERICA INC | New York | E420 Health Care | $392.3M | 13 |
