| NAZARETH UNIVERSITY | Rochester | B420 Education | $138.4M | 18 |
| SARAH LAWRENCE COLLEGE | Bronxville | B420 Education | $138.4M | 12 |
| WELLLIFE NETWORK INC | New Hyde Park | P820 Human Services | $137M | 7 |
| CARE DESIGN NY LLC | Albany | E86 Health Care | $136.5M | 14 |
| WESTERN NEW YORK MEDICAL PRACTICE PC | Rochester | E300 Health Care | $136.3M | 6 |
| HUDSON EAST RIVER SYSTEMS LLC | New York | E12 Health Care | $136.1M | 5 |
| Horace Mann School | Bronx | B200 Education | $134.4M | 12 |
| CENTER FOR EMPLOYMENT OPPORTUNITIES INC | New York | J20 Employment | $134M | 8 |
| ONEIDA HEALTH SYSTEMS | Oneida | E220 Health Care | $132.9M | 14 |
| LVMH MOET HENNESSY LOUIS VUITTON INC | New York | — | $132.2M | 0 |
| ST JOSEPH'S UNIVERSITY NEW YORK | Brooklyn | B420 Education | $132M | 20 |
| DIVISION 1181 ATU - NEW YORK WELFARE | Valley Stream | — | $131.2M | 6 |
| NY44 HEALTH BENEFITS PLAN TRUST | West Seneca | Y44 Mutual & Membership Benefit | $130.6M | 0 |
| ST MARYS HOSPITAL FOR CHILDREN INC | Bayside | E240 Health Care | $130.5M | 13 |
| UNIVERSITY OF MOUNT SAINT VINCENT | Riverdale | B420 Education | $130.3M | 8 |
| MONDELEZ GLOBAL LLC GROUP | New York | Y43 Mutual & Membership Benefit | $130.3M | 1 |
| CALVARY HOSPITAL INC | Bronx | E240 Health Care | $129.8M | 14 |
| INTERNATIONAL AIDS VACCINE | New York | Q300 International, Foreign Affairs & National Security | $129.7M | 11 |
| PAINTING INDUSTRY INSURANCE FUND | New York | — | $129.6M | 12 |
| BROOKLYN NAVY YARD DEVELOPMENT CORP | Brooklyn | S200 Community Improvement & Capacity Building | $129.6M | 18 |
| BRAVERHOOD LTD | Brooklyn | B990 Education | $129.5M | 9 |
| ETHICAL CULTURE FIELDSTON SCHOOL | New York | B200 Education | $129.3M | 25 |
| NIAGARA FALLS MEMORIAL MEDICAL CENTER | Niagara Falls | E220 Health Care | $128.4M | 13 |
| LOCAL 282 WELFARE TRUST FUND | Lake Success | — | $128.3M | 6 |
| SUE & EDGAR WACHENHEIM FOUNDATION | Purchase | — | $127.2M | 0 |
| STEPHEN A SCHWARZMAN FOUNDATION | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $127.1M | 2 |
| INDEPENDENT SUPPORT SERVICES INC | Monticello | F30 Mental Health & Crisis Intervention | $127M | 4 |
| NEW YORK EYE & EAR INFIRMARY | New York | E240 Health Care | $126.8M | 17 |
| ELIZABETH SETON PEDIATRIC CENTER | Yonkers | — | $125.9M | 8 |
| Service Employees International Union Local | New York | — | $125.6M | 116 |
| PROFESSIONAL FOOTBALL PLAYERS' INSTRUST | New York | — | $124.9M | 0 |
| WMC-New York Inc | Valhalla | E20 Health Care | $124.6M | 10 |
| The New York Community Hospital of Brooklyn Inc | Brooklyn | E220 Health Care | $124.4M | 16 |
| The Wallace Foundation | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $124.1M | 7 |
| GOOD SHEPHERD SERVICES | New York | P20 Human Services | $123.8M | 7 |
| SVCMC INC | New York | E31 Health Care | $123.7M | 8 |
| NEWARK-WAYNE COMMUNITY HOSPITAL | Newark | E220 Health Care | $123.1M | 13 |
| CENTER FOR INTERNET SECURITY INC | East Greenbush | W50 Public & Societal Benefit | $123M | 17 |
| HELP USA INC AND AFFILIATES | New York | L410 Housing & Shelter | $122.6M | 17 |
| NATHAN LITTAUER HOSPITAL ASSOCIATION | Gloversville | E220 Health Care | $122.5M | 8 |
| THE EPOCH TIMES ASSOCIATION INC | New York | A23 Arts, Culture & Humanities | $122.1M | 2 |
| RENSSELAER COLUMBIA GREENE GROUP | Castleton On Hudson | — | $122M | 0 |
| CATHOLIC HEALTH SYSTEM OF LONG ISLAND | Rockville Centre | — | $121.5M | 8 |
| REGIONAL FOOD BANK | Latham | K31Z Food, Agriculture & Nutrition | $121.1M | 8 |
| Heartshare Human Services of New York | Brooklyn | P200 Human Services | $120.9M | 11 |
| CATHOLIC CHARITIES NEIGHBORHOOD | Brooklyn | P200 Human Services | $120.7M | 13 |
| 199 PHILANTHROPIC FUND | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $120.3M | 0 |
| Putnam Hospital Center | Carmel | E220 Health Care | $119.2M | 14 |
| EHS INC | Buffalo | G81Z Diseases, Disorders & Medical Disciplines | $118.8M | 10 |
| ALFRED P SLOAN FOUNDATION | New York | B82 Education | $118.4M | 15 |
