| ORLANDO REHABILITATION GROUP INC | Bala Cynwyd | E910 Health Care | $73.1M | 10 |
| JEWISH FEDERATION OF GREATER | Philadelphia | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $73M | 12 |
| MILLCREEK COMMUNITY HOSPITAL | Erie | E220 Health Care | $72.8M | 13 |
| ST LUKE'S HEALTH NETWORK INC | Allentown | E220 Health Care | $72.6M | 17 |
| LIFEPATH INC | Bethlehem | P8XZ Human Services | $72.3M | 9 |
| CATHERINE HERSHEY SCHOOLS FOR EARLY LEARNING | Hershey | B21 Education | $72.3M | 12 |
| LYCOMING COLLEGE | Williamsport | B420 Education | $72.2M | 13 |
| Enbridge Employee Services Inc Welfare | Pittsburgh | — | $72.1M | 1 |
| NORTHWESTERN REGION EMPLOYEE | Erie | — | $71.9M | 0 |
| MAGEE REHABILITATION HOSPITAL | Philadelphia | E240 Health Care | $71.6M | 8 |
| Local 22 Phila Firefighters Health Fund | Philadelphia | — | $71.3M | 1 |
| PRESSLEY RIDGE | Pittsburgh | — | $71.3M | 9 |
| VIA AFFILIATES | Doylestown | E110 Health Care | $71.2M | 10 |
| JEVS HUMAN SERVICES | Philadelphia | — | $71.2M | 16 |
| MERAKEY USA | Lafayette Hill | E21 Health Care | $70.9M | 13 |
| INSPIRITEC INC | Philadelphia | B99 Education | $70.7M | 8 |
| REGENTS OF THE MERCERSBURG COLLEGE | Mercersburg | B250 Education | $70.6M | 12 |
| SENIOR HEALTH PROPERTIES-SOUTH INC | Bala Cynwyd | P80Z Human Services | $70.6M | 11 |
| AIDS CARE GROUP | Chester | G81 Diseases, Disorders & Medical Disciplines | $70.6M | 20 |
| Hemophilia Center of Western PA | Pittsburgh | E30 Health Care | $70.4M | 7 |
| CENTRAL PENNSYLVANIA SCHOLARSHIP FUND | Tyrone | B82 Education | $69.6M | 3 |
| OSF GENPROF LIABILITY | Pittsburgh | — | $69.4M | 1 |
| PENN STATE HEALTH LANCASTER MEDICAL | Hershey | E22 Health Care | $69.3M | 17 |
| Operation Warm Inc | Glen Mills | P60 Human Services | $69.2M | 9 |
| PENNSYLVANIA INTEREST ON LAWYER | Harrisburg | — | $68.2M | 2 |
| DIAMOND CREDIT UNION | Pottstown | — | $68M | 8 |
| Children's Health Care Associates of NJ PC | Philadelphia | E20 Health Care | $67.4M | 17 |
| COLLEGIUM CHARTER SCHOOL | Exton | B20 Education | $67.4M | 5 |
| PHILADELPHIA WORKS INC | Philadelphia | J20 Employment | $67.3M | 6 |
| CHH Community Health | Philadelphia | E22 Health Care | $67.2M | 0 |
| KIDSPEACE NATIONAL CENTERS FOR | Schnecksville | F330 Mental Health & Crisis Intervention | $66.5M | 9 |
| UNITED CHURCH OF CHRIST HOMES INC | Camp Hill | P750 Human Services | $66.5M | 9 |
| TRINITY HEALTH MID-ATLANTIC MEDICAL | Langhorne | E030 Health Care | $66.5M | 14 |
| TURNING POINTS FOR CHILDREN | Philadelphia | P400 Human Services | $66M | 6 |
| MENNO-HAVEN INC | Chambersburg | P750 Human Services | $65.9M | 10 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL | Collegeville | Y43 Mutual & Membership Benefit | $65.3M | 3 |
| THE WRIGHT CENTER MEDICAL GROUP | Scranton | X00Z Religion-Related | $64.8M | 13 |
| WAYNESBURG UNIVERSITY | Waynesburg | B420 Education | $64.8M | 10 |
| Communities of Don Guanella and Divine Providence | Philadelphia | — | $64.6M | 9 |
| CHESTNUT HILL COLLEGE | Philadelphia | B430 Education | $64.2M | 8 |
| HILLMAN FAMILY FOUNDATIONS | Pittsburgh | — | $64M | 6 |
| COMMISSION ON ECONOMIC OPPORTUNITY | Wilkesbarre | L80Z Housing & Shelter | $63.9M | 3 |
| GWYNEDD MERCY UNIVERSITY | Gwynedd Valley | B420 Education | $63.9M | 11 |
| PHILADELPHIA FEDERATION OF TEACHERS | Philadelphia | — | $63.8M | 1 |
| Temple Physicians Inc | Philadelphia | E99 Health Care | $63.6M | 19 |
| PENNSYLVANIA LEADERSHIP | West Chester | B20 Education | $63.4M | 7 |
| BELCO COMMUNITY CREDIT UNION | Harrisburg | — | $63.2M | 11 |
| WESLEY FAMILY SERVICES | Pittsburgh | P40 Human Services | $63.1M | 7 |
| ABH Pennsylvania Childrens Services Inc | Villanova | F33 Mental Health & Crisis Intervention | $63.1M | 13 |
| SPIRITRUST LUTHERAN | York | P750 Human Services | $63M | 7 |
