| ST LUKE'S HEALTH NETWORK INC | Allentown | E220 Health Care | $77.3M | 18 |
| NEUMANN UNIVERSITY | Aston | B420 Education | $76.7M | 14 |
| INSIGHT PA CYBER CHARTER SCHOOL | Exton | B29 Education | $76.2M | 7 |
| MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION | Pittsburgh | E24 Health Care | $76.2M | 7 |
| CARLOW UNIVERSITY | Pittsburgh | B420 Education | $76.1M | 13 |
| Operating Engineers Local 66 Welfare Fund | Pittsburgh | — | $75.7M | 0 |
| AMERICAN COLLEGE OF PHYSICIANS INC | Philadelphia | E030 Health Care | $75.5M | 17 |
| Local 22 Phila Firefighters Health Fund | Philadelphia | — | $75.3M | 1 |
| PINNACLE HEALTH REGIONAL PHYSICIANS | Harrisburg | E220 Health Care | $74.9M | 16 |
| Episcopal Academy | Newtown Square | B200 Education | $74.8M | 7 |
| PHILADELPHIA WORKS INC | Philadelphia | J20 Employment | $74.4M | 5 |
| WESTERN PENNSYLVANIA ELECTRICAL EMPLOYEES INSURANCE TRUST FUND | Pittsburgh | — | $74.3M | 0 |
| PRESSLEY RIDGE | Pittsburgh | — | $74.2M | 9 |
| VIA AFFILIATES | Doylestown | E110 Health Care | $74.2M | 11 |
| KENDAL-CROSSLANDS COMMUNITIES | Kennett Square | P750 Human Services | $74.1M | 9 |
| The Magee Memorial Hospital for Convalescents | Philadelphia | E240 Health Care | $74M | 8 |
| MAIN LINE HEALTH HOMECARE AND HOSPICE | Radnor | P44Z Human Services | $73.9M | 10 |
| CENTRAL PENNSYLVANIA SCHOLARSHIP FUND | Tyrone | B82 Education | $73.9M | 3 |
| CARNEGIE INSTITUTE | Pittsburgh | A500 Arts, Culture & Humanities | $73.2M | 14 |
| ORLANDO REHABILITATION GROUP INC | Bala Cynwyd | E910 Health Care | $73.1M | 10 |
| JEWISH FEDERATION OF GREATER PHILADELPHIA | Philadelphia | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $73M | 12 |
| PENNSYLVANIA TRUST | Milton | — | $72.8M | 0 |
| SKILLS OF CENTRAL PENNSYLVANIA INC | State College | P82Z Human Services | $72.5M | 3 |
| LIFEPATH INC | Bethlehem | P8XZ Human Services | $72.3M | 9 |
| CATHERINE HERSHEY SCHOOLS FOR EARLY LEARNING | Hershey | B21 Education | $72.3M | 12 |
| WALNUT HOME THERAPEUTICS INC | Philadelphia | E92Z Health Care | $72.2M | 0 |
| MABEL PEW MYRIN TRUST | Philadelphia | — | $71.8M | 1 |
| URBAN AFFAIRS COALITION | Philadelphia | — | $71.1M | 9 |
| PHEAA STUDENT LOAN FOUNDATION INC | Harrisburg | W60 Public & Societal Benefit | $71M | 3 |
| ELK REGIONAL HEALTH CENTER | St Marys | E220 Health Care | $70.9M | 11 |
| ST LUKE'S HOSPITAL - EASTON CAMPUS | Allentown | E20 Health Care | $70.8M | 2 |
| THE JAMES FAMILY CHARITABLE TRUST | Jenkintown | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $70.8M | 8 |
| REGENTS OF THE MERCERSBURG COLLEGE | Mercersburg | B250 Education | $70.6M | 12 |
| AIDS CARE GROUP | Chester | G81 Diseases, Disorders & Medical Disciplines | $70.6M | 20 |
| PERFORMANCE REVIEW INSTITUTE INC | Warrendale | — | $70.3M | 9 |
| Communities of Don Guanella and Divine Providence | Philadelphia | — | $70.3M | 8 |
| NORTHWESTERN REGION EMPLOYEE BENEFIT TRUST | Erie | — | $70.1M | 0 |
| Temple Physicians Inc | Philadelphia | E99 Health Care | $70M | 19 |
| THE WRIGHT CENTER MEDICAL GROUP | Scranton | X00Z Religion-Related | $70M | 17 |
| PENNSYLVANIA LEADERSHIP CHARTER SCHOOL | West Chester | B20 Education | $70M | 6 |
| WESTMINSTER COLLEGE | New Wilmington | B420 Education | $69.8M | 9 |
| PENNSYLVANIA INTEREST ON LAWYER TRUST ACCOUNTS BOARD | Harrisburg | — | $69.5M | 4 |
| SHARING EXCESS | Philadelphia | K30 Food, Agriculture & Nutrition | $69.4M | 2 |
| OSF GENPROF LIABILITY | Pittsburgh | — | $69.4M | 1 |
| Operation Warm Inc | Glen Mills | P60 Human Services | $69.2M | 9 |
| ALLIED SERVICES FOUNDATION | Clarks Summit | E120 Health Care | $68.6M | 3 |
| WESLEY FAMILY SERVICES | Pittsburgh | P40 Human Services | $68.1M | 7 |
| DIAMOND CREDIT UNION | Pottstown | — | $68M | 8 |
| FAYETTE RESOURCES INC | Uniontown | P820 Human Services | $67.5M | 6 |
| Children's Health Care Associates of NJ PC | Philadelphia | E20 Health Care | $67.4M | 17 |
