| THE JAMES FAMILY CHARITABLE TRUST | Jenkintown | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $86.7M | 8 |
| PASSAVANT MEMORIAL HOMES | Pittsburgh | P700 Human Services | $86.1M | 4 |
| PHILHAVEN | York | F310 Mental Health & Crisis Intervention | $85.7M | 16 |
| WALNUT HOME THERAPEUTICS INC | Philadelphia | E92Z Health Care | $85.5M | 0 |
| GREATER PITTSBURGH COMMUNITY FOOD BANK | Duquesne | K310 Food, Agriculture & Nutrition | $85.4M | 10 |
| RICHARD J CARON FOUNDATION | Wernersville | F200 Mental Health & Crisis Intervention | $85.4M | 14 |
| PG&E Postretirement Medical Plan Trust Non- | Pittsburgh | — | $84.5M | 1 |
| PHILADELPHIA ORCHESTRA ASSOCIATION | Philadelphia | A690 Arts, Culture & Humanities | $84.4M | 10 |
| LYCOMING CLINTON JOINDER BOARD | Williamsport | P82Z Human Services | $84.4M | 2 |
| CARLOW UNIVERSITY | Pittsburgh | B420 Education | $84.3M | 10 |
| DEFENDER ASSOCIATION OF PHILADELPHIA | Philadelphia | I800 Crime & Legal-Related | $83.9M | 9 |
| PENNSYLVANIA STATE EDUCATION ASSOCIATION | Harrisburg | — | $83.9M | 59 |
| TRINITY HEALTH OF THE MID-ATLANTIC | Newtown Square | E210 Health Care | $83.6M | 12 |
| ADAMS ELECTRIC COOPERATIVE INC | Gettysburg | — | $83.5M | 17 |
| THE UNION LEAGUE OF PHILADELPHIA | Philadelphia | — | $83.4M | 13 |
| PMHCC INC | Philadelphia | F300 Mental Health & Crisis Intervention | $83.1M | 8 |
| MOUNTAIN VIEW CANCER ASSOCIATES INC | Pittsburgh | E20 Health Care | $82.6M | 0 |
| GOODWILL OF SOUTHWESTERN PENNSYLVANIA | Pittsburgh | J320 Employment | $82.3M | 9 |
| PITTSBURGH CARE PARTNERSHIP INC | Pittsburgh | E91 Health Care | $82.1M | 7 |
| GOOD SHEPHERD REHABILITATION NETWORK | Allentown | E120 Health Care | $81.1M | 11 |
| INSIGHT PA CYBER CHARTER SCHOOL | Exton | B29 Education | $81M | 5 |
| J E BARBEY 8 FBO TENACRE FDN | Pittsburgh | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $81M | 3 |
| THE PITTSBURGH FOUNDATION | Pittsburgh | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $80.3M | 10 |
| Pennsylvania Mountains Healthcare | DuBois | Y43 Mutual & Membership Benefit | $80.2M | 0 |
| GEISINGER-BLOOMSBURG HOSPITAL | Danville | E20 Health Care | $79.9M | 14 |
| FREEDOM CREDIT UNION | Warminster | — | $79.7M | 16 |
| SPECIAL PEOPLE IN NORTHEAST INC | Philadelphia | P82Z Human Services | $79.5M | 19 |
| INTEALTH | Philadelphia | B900 Education | $79.1M | 13 |
| WILLIAM PENN CHARTER SCHOOL INC | Philadelphia | B200 Education | $78.4M | 10 |
| MASTERY SCHOOLS OF CAMDEN INC | Philadelphia | B28 Education | $78.2M | 5 |
| DOLLAR ENERGY FUND INC | Pittsburgh | L820 Housing & Shelter | $78.1M | 7 |
| THE REINVESTMENT FUND INC | Philadelphia | S200 Community Improvement & Capacity Building | $78M | 14 |
| ALLIED HEALTH CARE SERVICES | Clarks Summit | P73Z Human Services | $77.7M | 8 |
| EMERGENCY CARE RESEARCH INSTITUTE | Plymouth Meeting | E64E Health Care | $77.6M | 13 |
| NEUMANN UNIVERSITY | Aston | B420 Education | $76.7M | 14 |
| MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION | Pittsburgh | E24 Health Care | $76.2M | 7 |
| MAIN LINE HEALTH HOMECARE AND HOSPICE | Newtown Square | P44Z Human Services | $76.1M | 20 |
| GSL HOSPITAL | Allentown | E20 Health Care | $76.1M | 1 |
| American College of Physicians Inc | Philadelphia | E030 Health Care | $75.9M | 18 |
| Operating Engineers Local 66 Welfare Fund | Pittsburgh | — | $75.7M | 0 |
| Philabundance | Philadelphia | K31Z Food, Agriculture & Nutrition | $75.6M | 7 |
| ACTS RETIREMENT SERVICES INC GRP EXEMP | Fort Washington | — | $75.4M | 33 |
| Episcopal Academy | Newtown Square | B200 Education | $74.8M | 7 |
| ST JOSEPH MEDICAL GROUP | Hershey | E32 Health Care | $74.6M | 10 |
| Pinnacle Health Regional Physicians | Harrisburg | E220 Health Care | $74.5M | 15 |
| KENDAL-CROSSLANDS COMMUNITIES | Kennett Square | P750 Human Services | $74.1M | 9 |
| URBAN AFFAIRS COALITION | Philadelphia | — | $74M | 9 |
| PROJECT HOME | Philadelphia | P850 Human Services | $73.8M | 9 |
| HARRISBURG UNIVERSITY OF | Harrisburg | B43 Education | $73.4M | 8 |
| CARNEGIE INSTITUTE | Pittsburgh | A500 Arts, Culture & Humanities | $73.2M | 14 |
