| Scott & White Hospital-Marble Falls | Dallas | E22 Health Care | $145.4M | 22 |
| C2C INNOVATIVE SOLUTIONS INC | Austin | E19 Health Care | $143.4M | 19 |
| THE 85 FUND | Fort Worth | I01 Crime & Legal-Related | $143.1M | 6 |
| RIVERWALK EDUCATION FOUNDATION INC | San Antonio | B29 Education | $141.9M | 31 |
| Active Employees MedicalDental and Life Insurance Plan(s) for Employees of AAFES Voluntary Employees' Beneficiary Association | Dallas | — | $141.5M | 0 |
| CENTRAL TEXAS FOOD BANK INC | Austin | K31Z Food, Agriculture & Nutrition | $141.4M | 10 |
| AUSTIN TRAVIS COUNTY MHMR CENTER DBA INTEGRAL CARE | Austin | F320 Mental Health & Crisis Intervention | $141.3M | 10 |
| UNIVERSITY OF MARY HARDIN-BAYLOR | Belton | B430 Education | $138.6M | 9 |
| THE FOUNDATION | Austin | B20 Education | $138.3M | 0 |
| Great Hearts America-Texas | San Antonio | C27 Environment | $137.4M | 13 |
| THE SEALY & SMITH FOUNDATION | Galveston | E110 Health Care | $135.7M | 9 |
| Texas Health Presbyterian Hospital Allen | Allen | E220 Health Care | $135.7M | 20 |
| University of St Thomas | Houston | B430 Education | $135.7M | 15 |
| Tarrant Area Food Bank | Fort Worth | — | $135M | 10 |
| Hendrick Medical Center Brownwood | Abilene | E22 Health Care | $133.6M | 18 |
| GULF COAST REGIONAL BLOOD CENTER | Houston | E610 Health Care | $132.7M | 16 |
| Austin College | Sherman | B430 Education | $130.8M | 10 |
| SOUTHWESTERN UNIVERSITY | Georgetown | B420 Education | $129.9M | 14 |
| Qualtex Laboratories | San Antonio | E61 Health Care | $129.4M | 7 |
| METHODIST PRIMARY CARE GROUP | Houston | T110 Philanthropy, Voluntarism & Grantmaking Foundations | $129M | 21 |
| KARNES ELECTRIC COOPERATIVE INC | Karnes City | — | $128M | 14 |
| TEXAS MEDICAL CENTER | Houston | E210 Health Care | $127.7M | 17 |
| AIDS ARMS INC | Dallas | G81Z Diseases, Disorders & Medical Disciplines | $127.3M | 16 |
| ARROW CHILD & FAMILY MINISTRIES COMBINED AFFILIATE GROUP | Spring | S50 Community Improvement & Capacity Building | $126.9M | 10 |
| BANK OF AMERICA SHORT TERM DISABILITY TRUST | Dallas | Y43 Mutual & Membership Benefit | $126.8M | 0 |
| KNAPP MEDICAL CENTER | Weslaco | E220 Health Care | $126.3M | 9 |
| LUTHERAN SOCIAL SERVICES OF THE SOUTH INC | Austin | P200 Human Services | $125.5M | 17 |
| Memorial Hermann Pharmacy Services LLC | Houston | E60 Health Care | $125.2M | 4 |
| TEXANS CREDIT UNION | Richardson | — | $123.6M | 9 |
| TEXAS LIFE AND HEALTH INSURANCE GUARANTY ASSOCIATION | Austin | — | $123.5M | 2 |
| CROSSSEED TEXAS NON PROFIT | Fort Worth | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $121.9M | 0 |
| LAURIE AND REED MORIAN FOUNDATION | Houston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $121M | 1 |
| IPS Enterprises Inc | Weslaco | B19 Education | $119.7M | 11 |
| TEXAS TRUST CREDIT UNION | Arlington | — | $119.5M | 9 |
| AUSTIN COMMUNITY FOUNDATION INC | Austin | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $114.7M | 6 |
| METHODIST RETIREMENT COMMUNITIES GROUP RETURN | The Woodlands | — | $114.6M | 7 |
| BANDERA ELECTRIC COOPERATIVE INC | Bandera | — | $114.4M | 24 |
| Shannon Medical Management | San Angelo | E19 Health Care | $113.6M | 9 |
| University of Dallas | Irving | B42Z Education | $113.2M | 25 |
| Burlington Northern Santa Fe Welfare Benefit Trust | Fort Worth | — | $112M | 1 |
| UPSHUR-RURAL ELECTRIC COOPERATIVE CORPORATION | Gilmer | — | $110.6M | 18 |
| COMMUNITY HOSPITAL OF BRAZOSPORT | Lake Jackson | E220 Health Care | $110.4M | 12 |
| CHILDREN'S MEDICAL CENTER FOUNDATION | Dallas | E11 Health Care | $109.8M | 4 |
| DEEP EAST TEXAS ELECTRIC COOPERATIVE INC | San Augustine | — | $109.3M | 19 |
| BAYLOR ST LUKE'S MEDICAL GROUP | Houston | E110 Health Care | $109.2M | 13 |
| IBEW-NECA SOUTHWESTERN HEALTH & BENEFIT FUND | Dallas | — | $108.2M | 0 |
| SAN ANTONIO AREA FOUNDATION | San Antonio | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $108M | 10 |
| ST LUKE'S HOSPITAL AT THE VINTAGE | Houston | E21 Health Care | $107.6M | 7 |
| Texas Access to Justice Foundation | Austin | — | $106.2M | 4 |
| SAN BERNARD ELECTRIC COOPERATIVE INC | Bellville | — | $105.9M | 18 |
