| THE DALLAS FOUNDATION | Dallas | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $100.6M | 9 |
| DATCU | Corinth | — | $100.5M | 20 |
| LOWER RIO GRANDE VALLEY WORKFORCE | McAllen | J20 Employment | $100.3M | 3 |
| THE FOUNDATION | Austin | B20 Education | $100.1M | 0 |
| CATHOLIC CHARITIES OF THE ARCHDIOCESE OF | Houston | P20Z Human Services | $99.4M | 13 |
| TEXAS ASSOCIATION OF SCHOOL BOARDS INC | Austin | B030 Education | $98.8M | 16 |
| TEXANS CREDIT UNION | Richardson | — | $98.6M | 9 |
| TEXAS GUARANTEED STUDENT LOAN | Round Rock | W600 Public & Societal Benefit | $98.5M | 22 |
| COMMUNITY HOSPITAL OF BRAZOSPORT | Lake Jackson | E220 Health Care | $97.7M | 11 |
| EL CENTRO DEL BARRIO INC | San Antonio | P200 Human Services | $97.6M | 10 |
| THE METHODIST HOSPITAL FOUNDATION | Houston | E20 Health Care | $97.2M | 4 |
| Austin College | Sherman | B430 Education | $97.1M | 7 |
| Memorial Hermann Hospital Based Physician | Houston | E62 Health Care | $96.9M | 9 |
| EDUCATION SERVICE CENTER REGION XIII | Austin | B99Z Education | $96.8M | 15 |
| TRINITY BASIN PREPARATORY INC | Grand Prairie | B20 Education | $96.4M | 7 |
| WI Cook Foundation Inc | Fort Worth | E11 Health Care | $95.1M | 16 |
| Jubilee Academic Center Inc | San Antonio | B29 Education | $94.4M | 19 |
| Mother Frances Hospital - Jacksonville | Irving | E21 Health Care | $94.2M | 15 |
| TEXAS PROPERTY AND CASUALTY INSURANCE GUARANTY ASSOCIATION | Austin | — | $94.1M | 8 |
| LYNTEGAR ELECTRIC COOPERATIVE INC | Tahoka | — | $92.7M | 18 |
| TEXAS TECH FOUNDATION INC | Lubbock | B110 Education | $92.7M | 2 |
| VANGUARD ACADEMY INC | Edinburg | B112 Education | $92.2M | 5 |
| LIFEGIFT ORGAN DONATION CENTER | Houston | E61Z Health Care | $92.1M | 11 |
| Texas Medical Center Central Heating and Cooling Services Corporation | Houston | E60 Health Care | $91.7M | 11 |
| ST LUKE'S COMMUNITY DEVELOPMENT | Houston | E20 Health Care | $91.7M | 9 |
| Texas Access to Justice Foundation | Austin | — | $91.7M | 4 |
| AMPLIFY CREDIT UNION | Austin | — | $91.5M | 40 |
| SOUTHWEST TRANSPLANT ALLIANCE INC | Dallas | E65Z Health Care | $90.7M | 8 |
| WOOD COUNTY ELECTRIC COOPERATIVE | Quitman | — | $90.4M | 15 |
| Episcopal Health Foundation | Houston | E70 Health Care | $88.7M | 9 |
| Children's Physician Services of South Texas | Corpus Christi | E320 Health Care | $88.5M | 12 |
| St John's School | Houston | — | $88.2M | 11 |
| RIO GRANDE ELECTRIC COOP INC | Brackettville | — | $88.2M | 23 |
| Parker University | Dallas | B500 Education | $87.4M | 8 |
| CAREFLITE | Irving | E62 Health Care | $87M | 11 |
| CENTRAL TEXAS ELECTRIC COOPERATIVE INC | Fredericksburg | — | $86.9M | 20 |
| COMMUNITY FOUNDATION OF NORTH TEXAS (TAX | Fort Worth | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $86.3M | 5 |
| Huntsville Community Hospital Inc | Huntsville | E22 Health Care | $85.8M | 14 |
| FIRST SERVICE CREDIT UNION | Houston | — | $85.5M | 17 |
| TEXAS STATE AFFORDABLE HOUSING | Austin | L20 Housing & Shelter | $85.2M | 11 |
| BIENVIVIR SENIOR HEALTH SERVICES | El Paso | E3XZ Health Care | $84.8M | 7 |
| SCHARBAUER FOUNDATION INC | Midland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $84.6M | 4 |
| Texas Health Harris Methodist Hospital | Cleburne | E220 Health Care | $84.6M | 16 |
| GOODWILL INDUSTRIES OF SAN ANTONIO | San Antonio | — | $84.5M | 10 |
| Hardin-Simmons University | Abilene | B430 Education | $84.3M | 13 |
| TEXAS BIOMEDICAL RESEARCH INSTITUTE | San Antonio | H40 Medical Research | $83.2M | 12 |
| UTMB HEALTHCARE SYSTEMS INC | Galveston | E20 Health Care | $83M | 14 |
| Houston Zoo Inc | Houston | D115 Animal-Related | $82.5M | 9 |
| EAST TEXAS PROFESSIONAL CREDIT UNION | Longview | — | $82.5M | 11 |
| CHILDREN'S ADVOCACY CENTERS | Austin | I72 Crime & Legal-Related | $82.4M | 11 |
