| NATIONAL SHOOTING SPORTS FOUNDATION INC | Shelton | — | $59M | 11 |
| Masonicare Health Center | Wallingford | P750 Human Services | $59M | 8 |
| SIKORSKY FINANCIAL CREDIT UNION | Stratford | — | $58.3M | 11 |
| CONTINUUM OF CARE INC | New Haven | — | $58M | 8 |
| OPTIMUS HEALTH CARE INC | Bridgeport | E30Z Health Care | $58M | 8 |
| THE COMMUNITY FOUNDATION FOR GREATER NEW | New Haven | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $55.3M | 7 |
| NATIONAL CHARITABLE ENDOWMENT INC | Darien | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $55.2M | 0 |
| Natchaug Hospital Inc | Mansfield Center | E31Z Health Care | $55.1M | 16 |
| LL Global Inc | Windsor | S41 Community Improvement & Capacity Building | $55M | 18 |
| COHEN VETERANS NETWORK INC | Stamford | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $54.7M | 2 |
| GOODWILL OF WESTERN AND | Bridgeport | J32Z Employment | $53.9M | 7 |
| ACHIEVEMENT FIRST RHODE ISLAND INC | New Haven | B29 Education | $53.4M | 5 |
| Vassar Health Connecticut Inc | Sharon | E20 Health Care | $53.1M | 15 |
| GREENWICH ACADEMY INC | Greenwich | B200 Education | $51.2M | 11 |
| THE VILLAGE FOR FAMILIES AND CHILDREN | Hartford | P400 Human Services | $51M | 9 |
| COMMUNITY RESIDENCES INC | Newington | P700 Human Services | $50.9M | 5 |
| NEW ENGLAND HEALTH CARE EMPLOYEES | Hartford | — | $50.1M | 6 |
| SOUTHWEST COMMUNITY HEALTH CENTER INC | Bridgeport | — | $50M | 14 |
| CHURCH HOMES INC CONGREGATIONAL | Hartford | P750 Human Services | $48.7M | 9 |
| FAIR HAVEN COMMUNITY HEALTH CLINIC INC | New Haven | E32Z Health Care | $48.3M | 11 |
| INTERCOMMUNITY INC | East Hartford | F32Z Mental Health & Crisis Intervention | $47.5M | 10 |
| COMMUNITY RENEWAL TEAM INC | Hartford | P200 Human Services | $47.2M | 5 |
| GREENS FARMS ACADEMY INC | Greens Farms | B200 Education | $46.4M | 13 |
| SCUS HEAD START PROGRAMS INC | Fairfield | B21 Education | $45.9M | 9 |
| THE CONNECTION INC | Middletown | F22Z Mental Health & Crisis Intervention | $45.1M | 11 |
| EDADVANCE | Litchfield | — | $44.5M | 11 |
| CARDINAL BAY INC | Shelton | L22 Housing & Shelter | $44.2M | 4 |
| CHURCH HOME OF HARTFORD INC | Bloomfield | P750 Human Services | $44M | 8 |
| CONNEX CREDIT UNION | North Haven | — | $43.6M | 19 |
| GOODWILL INDUSTRIES OF SOUTHERN | North Haven | — | $43.4M | 5 |
| CONNECTICUT BAR FOUNDATION | Hartford | I800 Crime & Legal-Related | $43.3M | 2 |
| MISS PORTER'S SCHOOL INC | Farmington | B250 Education | $43.2M | 8 |
| AMERICAN SCHOOL AT HARTFORD FOR THE | West Hartford | B280 Education | $42.9M | 7 |
| ALBERTUS MAGNUS COLLEGE | New Haven | B420 Education | $42.7M | 8 |
| AVON OLD FARMS SCHOOL INC | Avon | B250 Education | $42.4M | 7 |
| HOPKINS SCHOOL INCORPORATED | New Haven | B250 Education | $42.1M | 7 |
| COMMUNITY SOLUTIONS INC | Windsor | F20 Mental Health & Crisis Intervention | $42.1M | 7 |
| NEW OPPORTUNITIES INC | Waterbury | — | $42M | 5 |
| KING SCHOOL INC | Stamford | B200 Education | $42M | 7 |
| ACHIEVEMENT FIRST INC | New Haven | B29 Education | $41.9M | 8 |
| CONNECTICUT INSTITUTE FOR COMMUNITIES | Danbury | S30 Community Improvement & Capacity Building | $41.9M | 9 |
| APT Foundation Inc | New Haven | F200 Mental Health & Crisis Intervention | $41.9M | 7 |
| Rushford Center Inc | Meriden | F22Z Mental Health & Crisis Intervention | $41.4M | 15 |
| PLANNED PARENTHOOD OF | New Haven | E42 Health Care | $41M | 13 |
| TRUSTEES OF WESTMINSTER SCHOOL INC | Simsbury | B250 Education | $41M | 8 |
| GREATER HARTFORD COMMUNITY | Hartford | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $40.7M | 7 |
| THAMES VALLEY COUNCIL FOR COMMUNITY | Jewett City | S80Z Community Improvement & Capacity Building | $40.5M | 5 |
| BHcare Inc | North Haven | E192 Health Care | $40.3M | 9 |
| MHS PRIMARY CARE INC | Middletown | E32 Health Care | $40.2M | 8 |
| LOCAL 191 HEALTH SERVICE AND | Bridgeport | — | $40.1M | 3 |
