| Azusa Pacific University | Azusa | B430 Education | $301.8M | 21 |
| OPERATING ENGINEERS HEALTH AND WELFARE FUND | Pasadena | — | $300M | 7 |
| St Helena Hospital | St Helena | E220 Health Care | $298M | 21 |
| THE TRUST FOR PUBLIC LAND | San Francisco | C500 Environment | $297.4M | 25 |
| WESTERN STATES CARPENTERS VACATION TRUST | Los Angeles | — | $296.1M | 6 |
| KERN REGIONAL CENTER | Bakersfield | P820 Human Services | $292.7M | 5 |
| SEQUOIA CLIMATE FOUNDATION | Irvine | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $289.2M | 3 |
| Los Angeles Police Relief Assoc Inc | Los Angeles | — | $289.2M | 3 |
| GOODWILL INDUSTRIES OF SOUTHERN | Los Angeles | J320 Employment | $288.1M | 10 |
| SECOND HARVEST OF SILICON VALLEY | San Jose | K310 Food, Agriculture & Nutrition | $286.2M | 7 |
| UNITED STATES ENERGY FOUNDATION | San Francisco | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $286M | 22 |
| CALIFORNIA INDEPENDENT SYSTEM | Folsom | W99 Public & Societal Benefit | $285.9M | 23 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | Duarte | H30 Medical Research | $285.3M | 21 |
| ALLIANCE COLLEGE-READY PUBLIC SCHOOLS | Pasadena | B29 Education | $283.3M | 12 |
| FAMILY HEALTHCARE NETWORK | Visalia | E39Z Health Care | $282.6M | 7 |
| GEMOLOGICAL INSTITUTE OF AMERICA INC | Carlsbad | B600 Education | $281.8M | 29 |
| Torrance Health Association | Torrance | E110 Health Care | $280.6M | 13 |
| PRIDE Industries | Roseville | P20 Human Services | $279.8M | 14 |
| LOS ANGELES REGIONAL FOOD BANK | Los Angeles | — | $273.9M | 19 |
| TEAMSTERS MISCELLANEOUS SECURITY FUND | Pasadena | — | $272.6M | 0 |
| CALIFORNIA COMMUNITY FOUNDATION | Los Angeles | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $270.7M | 12 |
| THE SAN DIEGO FOUNDATION | San Diego | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $268.7M | 8 |
| Cottage Health | Santa Barbara | X00Z Religion-Related | $265.7M | 18 |
| VALLEY STRONG CU FKA | Bakersfield | W61 Public & Societal Benefit | $265.1M | 47 |
| WESTERN UNIVERSITY OF HEALTH SCIENCES | Pomona | — | $265.1M | 17 |
| THE MILKEN INSTITUTE | Santa Monica | — | $264.7M | 8 |
| PIH Health Downey Hospital | Downey | E220 Health Care | $262.2M | 17 |
| Ukiah Adventist Hospital | Ukiah | — | $261.5M | 26 |
| EDUCATIONAL MEDIA FOUNDATION | Rocklin | A340 Arts, Culture & Humanities | $261M | 19 |
| FAR NORTHERN COORDINATING COUNCIL | Redding | P110 Human Services | $258.6M | 8 |
| PACIFIC MARITIME ASSOCIATION | San Francisco | — | $258.3M | 10 |
| Public Health Institute | Oakland | E70Z Health Care | $258.3M | 14 |
| Labor Alliance Managed Trust Fund | Pleasanton | — | $255.2M | 0 |
| SANTE HEALTH FOUNDATION | Fresno | E70 Health Care | $251.4M | 0 |
| SOUTHEASTERN REGIONAL MEDICAL CENTER INC | Duarte | E24 Health Care | $251.3M | 17 |
| PACIFIC CLINICS | Campbell | P300 Human Services | $245.4M | 19 |
| POMONA COLLEGE | Claremont | B420 Education | $243.7M | 22 |
| CALIFORNIA CREDIT UNION | Glendale | — | $243.6M | 24 |
| UNITED AGRICULTURAL BENEFIT TRUST | Irvine | — | $242.1M | 1 |
| ACCESS SERVICES | El Monte | P520 Human Services | $242.1M | 16 |
| MIDWESTERN REGIONAL MEDICAL CENTER INC | Duarte | — | $241.7M | 16 |
| UNITED HEALTH CENTERS OF THE SAN JOAQUIN | Fresno | E320 Health Care | $241.4M | 10 |
| EDUCATIONAL EMPLOYEES CREDIT UNION | Fresno | — | $239.3M | 26 |
| ARGYROS FAMILY FOUNDATION | Costa Mesa | — | $239.2M | 0 |
| CHILDREN'S HOSPITAL LOS ANGELES | Los Angeles | — | $238.8M | 24 |
| CALIFORNIA TEACHERS ASSOCIATION | Burlingame | — | $238.6M | 33 |
| Barton Healthcare System | South Lake Tahoe | E220 Health Care | $237.6M | 12 |
| TECHNOLOGY CREDIT UNION | San Jose | — | $235.3M | 31 |
| Loma Linda University Health Care | Loma Linda | E110 Health Care | $235M | 22 |
| TIDES CENTER | San Francisco | P20 Human Services | $233.7M | 9 |
