| NORTHERN CALIFORNIA GENERAL TEAMSTERS SECURITY FUND | Stockton | — | $454.4M | 0 |
| SERGEY BRIN FAMILY FOUNDATION C/O PACIFIC FOUNDATION SERVICES | San Francisco | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $453.7M | 0 |
| VALLEY MOUNTAIN REGIONAL CENTER INC | Stockton | P82Z Human Services | $453.1M | 7 |
| MEMORIAL HEALTH SERVICES | Fountain Valley | E122 Health Care | $450.3M | 28 |
| LABORERS HEALTH & WELFARE TRUST FUND FOR NORTHERN CALIFORNIA | Pleasanton | — | $445.1M | 0 |
| Xie Foundation | Sunnyvale | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $438.5M | 0 |
| SRI INTERNATIONAL | Menlo Park | U200 Science & Technology | $437.9M | 28 |
| ZOOLOGICAL SOCIETY OF SAN DIEGO | San Diego | D500 Animal-Related | $437.6M | 12 |
| FAMILY HEALTH CENTERS OF SAN DIEGO INC | San Diego | E30Z Health Care | $436.4M | 34 |
| Eastern Los Angeles Regional Center | Alhambra | P820 Human Services | $424.5M | 9 |
| SAN DIEGO COUNTY CREDIT UNION | San Diego | — | $423M | 25 |
| SAG-AFTRA HEALTH PLAN | Burbank | — | $420.1M | 11 |
| WILLIAM AND BARBARA MARTIN FOUNDATION | Los Angeles | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $418.6M | 0 |
| CITY OF HOPE | Duarte | E050 Health Care | $413.3M | 16 |
| HARBOR DEVELOPMENTAL DISABILITIES FOUNDATION | Torrance | P820 Human Services | $411.3M | 7 |
| MARTIN LUTHER KING JR-LOS ANGELES HEALTHCARE CORPORATION | Los Angeles | E22 Health Care | $409.8M | 24 |
| STAR ONE CREDIT UNION | Sunnyvale | — | $409.8M | 21 |
| The David and Lucile Packard Foundation | Los Altos | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $407.6M | 5 |
| REDLANDS COMMUNITY HOSPITAL | Redlands | E220 Health Care | $407.1M | 7 |
| CATALIGHT FOUNDATION | Walnut Creek | E50Z Health Care | $400.8M | 17 |
| LOS ANGELES COUNTY DEVELOPMENTAL SERVICES FOUNDATION | Los Angeles | P820 Human Services | $398.5M | 9 |
| LOMA LINDA UNIVERSITY | Loma Linda | B430 Education | $397.8M | 25 |
| OROVILLE HOSPITAL | Oroville | E220 Health Care | $397.7M | 14 |
| CALSTART INC | Pasadena | Z99Z Unknown | $396.8M | 9 |
| PIH Health Good Samaritan Hospital | Los Angeles | E220 Health Care | $391.2M | 13 |
| SANSUM CLINIC | Sacramento | E320 Health Care | $387.2M | 19 |
| NORTH EAST MEDICAL SERVICES | Daly City | E300 Health Care | $385.1M | 14 |
| COMMUNITY HOSPITAL OF SAN BERNARDINO | San Francisco | E220 Health Care | $382.8M | 16 |
| Front Porch Communities and Services | Glendale | L22 Housing & Shelter | $380.2M | 16 |
| TEAMSTERS BENEFIT TRUST | Fremont | — | $379.8M | 0 |
| TIDES FOUNDATION | San Francisco | T300 Philanthropy, Voluntarism & Grantmaking Foundations | $368M | 3 |
| CRYSTAL STAIRS INC | Los Angeles | A25 Arts, Culture & Humanities | $365.3M | 8 |
| RETA TRUST | Walnut Creek | — | $363.4M | 3 |
| CCPOA BENEFIT TRUST FUND | Sacramento | — | $359.4M | 6 |
| THE ERIC AND WENDY SCHMIDT FUND FOR STRATEGIC INNOVATION | Palo Alto | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $357.9M | 3 |
| HOAG CLINIC | Newport Beach | E30 Health Care | $355.3M | 11 |
| LABORERS HEALTH & WELFARE TRUST FOR SOUTHERN CALIFORNIA % ROBERT GLAZA | Covina | — | $355M | 9 |
| CLIMATEWORKS FOUNDATION | San Francisco | U12 Science & Technology | $350.6M | 15 |
| PIH Health Physicians | Whittier | E320 Health Care | $348.8M | 17 |
| UNIVERSITY HEALTHCARE ALLIANCE | Newark | — | $348.1M | 21 |
| Sonora Community Hospital dba Adventist Health Sonora | Sonora | E220 Health Care | $346.7M | 24 |
| MARSHALL MEDICAL CENTER | Placerville | E220 Health Care | $343.6M | 12 |
| Adventist Health Physicians Network | Roseville | E32Z Health Care | $343.3M | 7 |
| LOMA LINDA UNIVERSITY SHARED SERVICES INC | San Bernardino | — | $340.1M | 32 |
| CONRAD N HILTON FOUNDATION | Westlake Village | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $340M | 16 |
| PACIFIC CLINICS | Los Gatos | P300 Human Services | $339.4M | 22 |
| COMMUNITY HOSPITALS OF CENTRAL CALIFORNIA | Fresno | E210 Health Care | $332.1M | 16 |
| OPERATING ENGINEERS HEALTH AND WELFARE TRUST FUND | Alameda | — | $330.6M | 0 |
| USC ARCADIA HOSPITAL | Arcadia | E220 Health Care | $330.6M | 14 |
| POMONA COLLEGE | Claremont | B420 Education | $329.4M | 21 |
