| SOUTH COVE COMMUNITY HEALTH CENTER INC | Boston | — | $62.4M | 7 |
| ELECTRICAL INDUSTRY LABOR MANAGEMENT COOPERATION TRUST | Dorchester | — | $62.3M | 3 |
| HANSJORG WYSS INSTITUTE FOR BIOLOGICALLY INSPIRED ENGINEERING AT HARVARD UNIV INC | Boston | B11 Education | $61.6M | 14 |
| QUINCY COMMUNITY ACTION PROGRAMS INC | Quincy | — | $61.4M | 6 |
| Newbridge on the charles inc | Boston | P75 Human Services | $61.4M | 21 |
| NICHOLS COLLEGE | Dudley | B420 Education | $61.1M | 9 |
| FIDUCIARY CHARITABLE FOUNDATION DBA FIDUCIARY TRUST CHARITABLE | Boston | T21Z Philanthropy, Voluntarism & Grantmaking Foundations | $61.1M | 0 |
| NATIONAL BUREAU OF ECONOMIC RESEARCH INC | Cambridge | V220 Social Science | $61M | 11 |
| UPHAMS CORNER HEALTH COMMITTEE INC | Dorchester | E31Z Health Care | $59.8M | 6 |
| SOUTHWEST BOSTON SENIOR SERVICES INC D/B/A ETHOS | Jamaica Plain | P81Z Human Services | $59.8M | 5 |
| ELDER SERVICES OF CAPE COD AND THE ISLANDS INC | South Dennis | P81Z Human Services | $59.4M | 7 |
| EDWARD M KENNEDY COMMUNITY HEALTH CENTER INC | Worcester | E320 Health Care | $59M | 10 |
| THE JEREMY AND HANNELORE GRANTHAM ENVIRONMENTAL TRUST | Boston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $58.9M | 0 |
| MASSMUTUAL FOUNDATION INC | Springfield | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $58.9M | 0 |
| HAMPSHIRE COLLEGE TRUSTEES | Amherst | B42Z Education | $58.4M | 15 |
| BERKSHIRE FACULTY SERVICES INC | Pittsfield | E31Z Health Care | $58.4M | 9 |
| CATHOLIC CHARITABLE BUREAU OF THE ARCHDIOCESE OF BOSTON INC | South Boston | — | $58.2M | 9 |
| NEW ENGLAND LIFE FLIGHT INC | Bedford | E62 Health Care | $58M | 8 |
| CODMAN SQUARE HEALTH CENTER INC | Dorchester | E320 Health Care | $57.4M | 12 |
| MARINE BIOLOGICAL LABORATORY | Woods Hole | U500 Science & Technology | $57.3M | 14 |
| BERKSHIRE COUNTY ARC INC | Pittsfield | P82Z Human Services | $56.8M | 6 |
| CAREPARTNERS OF CONNECTICUT INC | Canton | E80 Health Care | $56M | 13 |
| SHARON & CRESCENT UNITED CREDIT UNION | Sharon | — | $56M | 21 |
| CENTERBOARD INC | Lynn | — | $55.9M | 3 |
| GOVERNOR DUMMER ACADEMY THE GOVERNOR'S ACADEMY | Byfield | B250 Education | $55.8M | 7 |
| MASSACHUSETTS TEACHERS ASSOCIATION | Quincy | — | $55.4M | 12 |
| HALLMARK HEALTH MEDICAL ASSOCIATES INC | Medford | E31 Health Care | $55.1M | 15 |
| St Anne's Credit Union | Fall River | — | $55M | 18 |
| SHEET METAL WORKERS LOCAL UNION NO 17 INSURANCE FUND | Dorchester | — | $54.7M | 1 |
| NEW ENGLAND AQUARIUM CORPORATION | Boston | D500 Animal-Related | $54.6M | 17 |
| THE BERKSHIRE SCHOOL INC | Sheffield | B250 Education | $54.6M | 7 |
| COMMUNITY HEALTH CONNECTIONS INC | Fitchburg | E20 Health Care | $54.5M | 8 |
| NORTH ATLANTIC STATES REGIONAL COUNCIL OF CARPENTERS | Boston | — | $54.4M | 20 |
| NONOTUCK RESOURCE ASSOCIATES INC | Northampton | P82Z Human Services | $54.2M | 7 |
| BETH ISRAEL LAHEY HEALTH SPECIALTY CARE F/K/A NORTHEAST MEDICAL PRACTICE | Charlestown | E30Z Health Care | $53.8M | 21 |
| CONCORD ACADEMY | Concord | B250 Education | $53.7M | 10 |
| THE KEY PROGRAM INCORPORATED | Westborough | P300 Human Services | $53.7M | 15 |
| BELMONT HILL SCHOOL INC | Belmont | B250 Education | $53.5M | 8 |
| DOUGLAS A THOM CLINIC INC | Framingham | F320 Mental Health & Crisis Intervention | $52.9M | 7 |
| SELF HELP INC | Brockton | P200 Human Services | $52.8M | 7 |
| ONE8 FOUNDATION | Boston | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $52.5M | 0 |
| TUFTS MEDICINE INTEGRATED NETWORK INC | Burlington | E80 Health Care | $52.5M | 16 |
| PEOPLE INCORPORATED | Fall River | J33Z Employment | $52.4M | 7 |
| NEW ENGLAND DEACONESS ASSOCIATION | Concord | E910 Health Care | $52.4M | 12 |
| EMERSON PRACTICE ASSOCIATES INC | Concord | E220 Health Care | $52.3M | 15 |
| BOSTON BALLET INC | Boston | A630 Arts, Culture & Humanities | $52M | 8 |
| THE SISTERS OF SAINT ANN INC | Paxton | B430 Education | $51.8M | 5 |
| North Hill Needham Inc | Needham | P750 Human Services | $51M | 15 |
| TRUSTEES OF THAYER ACADEMY INC | Braintree | B250 Education | $50.9M | 6 |
| NATIONAL ORGANIZATION FOR RARE DISORDERS INC | Quincy | — | $50.7M | 9 |
