| UPHAMS CORNER HEALTH COMMITTEE INC | Dorchester | E31Z Health Care | $59.8M | 6 |
| SOUTHWEST BOSTON SENIOR SERVICES INC | Jamaica Plain | P81Z Human Services | $59.8M | 5 |
| ELDER SERVICES OF CAPE COD AND THE | South Dennis | P81Z Human Services | $59.4M | 7 |
| THE JEREMY AND HANNELORE GRANTHAM | Boston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $58.9M | 0 |
| BERKSHIRE FACULTY SERVICES INC | Pittsfield | E31Z Health Care | $58.4M | 9 |
| NEW ENGLAND LIFE FLIGHT INC | Bedford | E62 Health Care | $58M | 8 |
| CODMAN SQUARE HEALTH CENTER INC | Dorchester | E320 Health Care | $57.4M | 12 |
| WAYSIDE YOUTH AND FAMILY SUPPORT | Framingham | P400 Human Services | $56.9M | 10 |
| BERKSHIRE COUNTY ARC INC | Pittsfield | P82Z Human Services | $56.8M | 6 |
| GREATER LYNN SENIOR SERVICES INC | Lynn | — | $56.2M | 9 |
| CAREPARTNERS OF CONNECTICUT INC | Canton | E80 Health Care | $56M | 13 |
| HALLMARK HEALTH MEDICAL ASSOCIATES INC | Medford | E31 Health Care | $55.1M | 15 |
| St Anne's Credit Union | Fall River | — | $55M | 18 |
| SHEET METAL WORKERS LOCAL UNION | Dorchester | — | $54.7M | 1 |
| GROTON SCHOOL | Groton | B250 Education | $54.7M | 7 |
| THE BERKSHIRE SCHOOL INC | Sheffield | B250 Education | $54.6M | 7 |
| ROAD TO RESPONSIBILITY INC | Marshfield | P82Z Human Services | $54.6M | 8 |
| EDWARD M KENNEDY COMMUNITY HEALTH | Worcester | E320 Health Care | $54.5M | 10 |
| COMMUNITY HEALTH CONNECTIONS INC | Fitchburg | E20 Health Care | $54.5M | 8 |
| NORTH ATLANTIC STATES REGIONAL COUNCIL | Boston | — | $54.4M | 20 |
| GOVERNOR DUMMER ACADEMY | Byfield | B250 Education | $54.3M | 7 |
| NONOTUCK RESOURCE ASSOCIATES INC | Northampton | P82Z Human Services | $54.2M | 7 |
| BETH ISRAEL LAHEY HEALTH SPECIALTY CARE | Charlestown | E30Z Health Care | $53.8M | 21 |
| CONCORD ACADEMY | Concord | B250 Education | $53.7M | 10 |
| THE KEY PROGRAM INCORPORATED | Westborough | P300 Human Services | $53.7M | 15 |
| MARINE BIOLOGICAL LABORATORY | Woods Hole | U500 Science & Technology | $53.6M | 15 |
| BELMONT HILL SCHOOL INC | Belmont | B250 Education | $53.5M | 8 |
| TABOR ACADEMY | Marion | B250 Education | $52.8M | 7 |
| SELF HELP INC | Brockton | P200 Human Services | $52.8M | 7 |
| ONE8 FOUNDATION | Boston | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $52.5M | 0 |
| TUFTS MEDICINE INTEGRATED NETWORK INC | Burlington | E80 Health Care | $52.5M | 16 |
| FIDUCIARY CHARITABLE FOUNDATION | Boston | T21Z Philanthropy, Voluntarism & Grantmaking Foundations | $52.4M | 0 |
| PEOPLE INCORPORATED | Fall River | J33Z Employment | $52.4M | 7 |
| NEW ENGLAND DEACONESS ASSOCIATION | Concord | E910 Health Care | $52.4M | 12 |
| EMERSON PRACTICE ASSOCIATES INC | Concord | E220 Health Care | $52.3M | 15 |
| THE SISTERS OF SAINT ANN INC | Paxton | B430 Education | $51.8M | 5 |
| Worcester City Campus Corporation | Shrewsbury | B19 Education | $51.7M | 6 |
| North Hill Needham Inc | Needham | P750 Human Services | $51M | 15 |
| VNA CARE NETWORK INC | Worcester | E21 Health Care | $50.8M | 10 |
| NATIONAL ORGANIZATION FOR RARE | Quincy | — | $50.7M | 9 |
| Children's Hospital Radiology | Boston | E112 Health Care | $50.5M | 14 |
| MASSACHUSETTS TEACHERS ASSOCIATION | Quincy | — | $50.5M | 10 |
| CH Neurology Foundation Inc | Boston | — | $50.4M | 22 |
| CARDINAL BROOK TRUST | Boston | — | $50.4M | 0 |
| VENTURE COMMUNITY SERVICES INC | Sturbridge | P820 Human Services | $50.1M | 9 |
| WORK INCORPORATED | Dorchester | J30Z Employment | $49.7M | 8 |
| LAHEY CLINIC FOUNDATION INC | Charlestown | E110 Health Care | $49.5M | 23 |
| CHMC Surgical Foundation Inc | Boston | E122 Health Care | $49.5M | 13 |
| CHAMPIONS OF LOVE FOUNDATION INC | Boston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $49.1M | 0 |
| BRISTOL AGING & WELLNESS INC | Fall River | P81Z Human Services | $49M | 8 |
