| DETROIT EMPLOYMENT SOLUTIONS CORPORATION | Detroit | J20 Employment | $84.4M | 8 |
| SOCIETY OF MANUFACTURING ENGINEERS | Southfield | S410 Community Improvement & Capacity Building | $83.7M | 11 |
| TRINITY CONTINUING CARE SERVICES | Livonia | E910 Health Care | $83.6M | 13 |
| THE EDISON INSTITUTE INC | Dearborn | A540 Arts, Culture & Humanities | $81.9M | 8 |
| University Corporation for Advanced | Ann Arbor | U410 Science & Technology | $81.6M | 11 |
| ELECTRICAL WORKERS' INSURANCE FUND | Madison Heights | — | $81.5M | 10 |
| MERCY HOME HEALTH | Livonia | E92Z Health Care | $80.9M | 17 |
| MACKINAC STRAITS HEALTH SYSTEM INC | St Ignace | E21 Health Care | $80.4M | 11 |
| HILLSDALE COMMUNITY HEALTH CENTER | Hillsdale | E32Z Health Care | $80.1M | 8 |
| MEDSTAR INC | Clinton Township | E620 Health Care | $79.5M | 7 |
| Easter Seals - Michigan Inc | Auburn Hills | P82 Human Services | $79.3M | 8 |
| DETROIT EDUCATION & RESEARCH | Detroit | E80 Health Care | $77.6M | 0 |
| HILLS & DALES GENERAL HOSPITAL INC | Cass City | E220 Health Care | $76.6M | 9 |
| FINANCIAL PLUS CREDIT UNION | Flint | — | $76.2M | 9 |
| MUNSON HEALTHCARE CHARLEVOIX | Charlevoix | E220 Health Care | $75.9M | 17 |
| THE RALPH C WILSON JR FOUNDATION | Detroit | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $75.8M | 13 |
| MYMICHIGAN MEDICAL CENTER CLARE | Clare | — | $75.6M | 12 |
| GREAT LAKES FISHERY COMMISSION | Ann Arbor | D330 Animal-Related | $75.6M | 6 |
| OPERATING ENGINEERS' LOCAL 324 VACATION | Troy | — | $75.1M | 5 |
| AGEWAYS NONPROFIT SENIOR SERVICES | Southfield | P81Z Human Services | $74.9M | 7 |
| VERSITI MICHIGAN INC | Grand Rapids | E61Z Health Care | $74.8M | 19 |
| ASPIRUS IRONWOOD HOSPITAL & CLINICS INC | Ironwood | E22Z Health Care | $74.2M | 26 |
| Three Rivers Health System Inc | Three Rivers | E22 Health Care | $73.8M | 16 |
| TRI-COUNTY ELECTRIC COOPERATIVE | Portland | — | $73.4M | 17 |
| 4FRONT CREDIT UNION | Traverse City | — | $72.3M | 7 |
| MYMICHIGAN MEDICAL CENTER WEST BRANCH | West Branch | E220 Health Care | $72.3M | 13 |
| Hospice of Michigan Inc | Ann Arbor | P74 Human Services | $72.2M | 15 |
| Kellogg Company Retired EES Welfare Benefit | Battle Creek | — | $71.8M | 0 |
| FOX RUN VILLAGE INC | Novi | L22 Housing & Shelter | $71.6M | 7 |
| THE DETROIT INSTITUTE OF ARTS | Detroit | A510 Arts, Culture & Humanities | $71.2M | 12 |
| COMPREHENSIVE SENIOR CARE CORPORATION | Battle Creek | — | $70.9M | 8 |
| MOBILE MEDICAL RESPONSE INC | Saginaw | E620 Health Care | $70.9M | 9 |
| ASPIRUS KEWEENAW HOSPITAL | Laurium | E22Z Health Care | $70.9M | 26 |
| AMERICAN EAGLE LIFECARE CORPORATION | Ann Arbor | E91 Health Care | $70.2M | 10 |
| Presque Isle Electric & Gas Co-op | Onaway | — | $69.7M | 0 |
| NORTHEAST MICHIGAN COMMUNITY | Alpena | P200 Human Services | $68.4M | 4 |
| TRUE COMMUNITY CREDIT UNION | Jackson | — | $67.6M | 20 |
| Michigan Laborers Vacation Fund | Lansing | — | $67.5M | 6 |
| AREA AGENCY ON AGING OF WESTERN | Grand Rapids | P81Z Human Services | $67.3M | 4 |
| RBC MINISTRIES | Grand Rapids | X20Z Religion-Related | $67M | 13 |
| American 1 Credit Union | Jackson | — | $66.4M | 9 |
| INTERLOCHEN CENTER FOR THE ARTS | Interlochen | A25 Arts, Culture & Humanities | $66M | 9 |
| ROSS EDUCATION HOLDINGS INC | Clinton Township | — | $65.4M | 7 |
| CREDIT UNIONS CHARTERED IN THE STATE OF | Ann Arbor | — | $64.5M | 13 |
| GENESEE EDUCATION CONSULTANT | Flint | B19 Education | $62.8M | 2 |
| FEEDING AMERICA WEST MICHIGAN | Kentwood | — | $62.7M | 3 |
| Spring Arbor University | Spring Arbor | B430 Education | $62.4M | 6 |
| WILDFIRE CREDIT UNION | Saginaw | — | $62.1M | 8 |
| JEWISH FEDERATION OF DETROIT | Bloomfield Hills | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $62M | 8 |
| Michigan Electrical Employees Health Plan | Madison Heights | — | $61.8M | 4 |
