| CRANBROOK EDUCATIONAL COMMUNITY | Bloomfield Hills | B200 Education | $87.1M | 13 |
| CREDIT UNIONS CHARTERED IN THE STATE OF MICHIGAN FRANKENMUTH CREDIT UNION | Frankenmuth | — | $86.4M | 8 |
| Michigan Laborers Health Care Fund | Lansing | — | $86.4M | 5 |
| SPARROW EATON HOSPITAL | Charlotte | E220 Health Care | $86.4M | 17 |
| MERCY HOME HEALTH | Livonia | E92Z Health Care | $85.3M | 16 |
| CHERRY STREET SERVICES INC | Grand Rapids | E320 Health Care | $85.1M | 7 |
| DETROIT EMPLOYMENT SOLUTIONS CORPORATION | Detroit | J20 Employment | $84.4M | 8 |
| MUNSON HEALTHCARE CHARLEVOIX HOSPITAL | Charlevoix | E220 Health Care | $84M | 16 |
| SOCIETY OF MANUFACTURING ENGINEERS | Southfield | S410 Community Improvement & Capacity Building | $83.7M | 11 |
| Northwood University | Midland | B430 Education | $83.3M | 12 |
| THE EDISON INSTITUTE INC | Dearborn | A540 Arts, Culture & Humanities | $81.9M | 8 |
| University Corporation for Advanced Internet Development | Ann Arbor | U410 Science & Technology | $81.6M | 11 |
| ELECTRICAL WORKERS' INSURANCE FUND | Madison Heights | — | $81.5M | 10 |
| Hospice of Michigan Inc | Ann Arbor | P74 Human Services | $81.3M | 18 |
| MACKINAC STRAITS HEALTH SYSTEM INC | St Ignace | E21 Health Care | $80.4M | 11 |
| William Davidson Foundation | Birmingham | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $80.4M | 2 |
| DETROIT EDUCATION & RESEARCH | Detroit | E80 Health Care | $79.5M | 0 |
| MEDSTAR INC | Clinton Township | E620 Health Care | $79.5M | 7 |
| Easter Seals - Michigan Inc | Auburn Hills | P82 Human Services | $79.3M | 8 |
| SPARROW CLINTON HOSPITAL | St Johns | E22 Health Care | $79.3M | 20 |
| ASPIRUS IRONWOOD HOSPITAL & CLINICS INC | Ironwood | E22Z Health Care | $78.3M | 23 |
| FOX RUN VILLAGE INC | Novi | L22 Housing & Shelter | $76.4M | 9 |
| 4FRONT CREDIT UNION | Traverse City | — | $76.3M | 10 |
| FOOD BANK OF EASTERN MICHIGAN | Flint | K310 Food, Agriculture & Nutrition | $76M | 2 |
| THE RALPH C WILSON JR FOUNDATION | Detroit | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $75.8M | 13 |
| GREAT LAKES FISHERY COMMISSION | Ann Arbor | D330 Animal-Related | $75.6M | 6 |
| OPERATING ENGINEERS' LOCAL 324 VACATION AND HOLIDAY FUND OF MICHIGAN | Troy | — | $75.1M | 5 |
| AGEWAYS NONPROFIT SENIOR SERVICES | Southfield | P81Z Human Services | $74.9M | 7 |
| VERSITI MICHIGAN INC | Grand Rapids | E61Z Health Care | $74.8M | 19 |
| SPARROW IONIA HOSPITAL | Ionia | E21 Health Care | $74.5M | 16 |
| MYMICHIGAN MEDICAL CENTER WEST BRANCH | West Branch | E220 Health Care | $74.4M | 11 |
| ASPIRUS KEWEENAW HOSPITAL | Laurium | E22Z Health Care | $74.2M | 23 |
| Three Rivers Health System Inc | Three Rivers | E22 Health Care | $73.8M | 16 |
| TRI-COUNTY ELECTRIC COOPERATIVE | Portland | — | $73.4M | 17 |
| Kellogg Company Retired EES Welfare Benefit Trust For CBE | Battle Creek | — | $71.8M | 0 |
| COMPREHENSIVE SENIOR CARE CORPORATION | Battle Creek | — | $70.9M | 8 |
| MOBILE MEDICAL RESPONSE INC | Saginaw | E620 Health Care | $70.9M | 9 |
| AMERICAN EAGLE LIFECARE CORPORATION | Ann Arbor | E91 Health Care | $70.2M | 10 |
| Presque Isle Electric & Gas Co-op | Onaway | — | $69.7M | 18 |
| SCHEURER HOSPITAL | Pigeon | E22Z Health Care | $68.7M | 19 |
| NORTHEAST MICHIGAN COMMUNITY SERVICE AGENCY INC | Alpena | P200 Human Services | $68.4M | 4 |
| IHM SENIOR LIVING COMMUNITY INC | Monroe | — | $68.2M | 3 |
| TRUE COMMUNITY CREDIT UNION | Jackson | — | $67.6M | 20 |
| Michigan Laborers Vacation Fund | Lansing | — | $67.5M | 6 |
| AREA AGENCY ON AGING OF WESTERN MICHIGAN INC | Grand Rapids | P81Z Human Services | $67.3M | 4 |
| RBC MINISTRIES | Grand Rapids | X20Z Religion-Related | $67M | 13 |
| American 1 Credit Union | Jackson | — | $66.4M | 9 |
| CHERRYLAND ELECTRIC COOPERATIVE INC | Grawn | — | $66.3M | 15 |
| JOHN E FETZER INSTITUTE INC | Kalamazoo | X99 Religion-Related | $66.1M | 8 |
| INTERLOCHEN CENTER FOR THE ARTS | Interlochen | A25 Arts, Culture & Humanities | $66M | 9 |
