| VERSITI INDIANA INC | Indianapolis | E610 Health Care | $87M | 18 |
| TIPMONT RURAL ELECTRIC MEMBERSHIP | Linden | — | $86.4M | 15 |
| HEALTHNET INC | Indianapolis | E20 Health Care | $85.5M | 16 |
| FRANCISCAN ACO INC | Indianapolis | E02 Health Care | $84.9M | 1 |
| DEKALB MEMORIAL HOSPITAL INC | Auburn | E220 Health Care | $82.8M | 20 |
| HEALTHLINC INC | Valparaiso | — | $82.4M | 8 |
| EVERENCE ASSOCIATION INC | Goshen | — | $81.8M | 10 |
| TURNING POINT USA INC | Indianapolis | Z99 Unknown | $81.7M | 9 |
| Damar Services Inc | Indianapolis | P820 Human Services | $81.1M | 9 |
| JACKSON COUNTY RURAL ELECTRIC MEMBERSHIP | Brownstown | Y22 Mutual & Membership Benefit | $80.5M | 16 |
| Hanover College | Hanover | B420 Education | $78.9M | 8 |
| HUNTINGTON MEMORIAL HOSPITAL INC | Huntington | E220 Health Care | $78.4M | 23 |
| UNIVERSITY MEDICAL DIAGNOSTIC ASSOCIATES | Indianapolis | E32Z Health Care | $77.5M | 14 |
| UNITED WAY OF CENTRAL INDIANA INC | Indianapolis | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $77.1M | 8 |
| INDIANA TEAMSTERS HEALTH BENEFITS PLAN | Indianapolis | — | $77.1M | 0 |
| WESTERN INDIANA ENERGY REMC | Vincennes | — | $77M | 14 |
| APPLIED RESEARCH INSTITUTE INC | Bloomington | S30 Community Improvement & Capacity Building | $76.9M | 10 |
| BOONE REMC | Lebanon In | — | $76.5M | 18 |
| Wabash College | Crawfordsville | B420 Education | $76.3M | 8 |
| ANDERSON UNIVERSITY INC | Anderson | B420 Education | $75.6M | 7 |
| COMMUNITY HOSPITAL OF NOBLE COUNTY INC | Kendallville | E20 Health Care | $75.6M | 22 |
| INDIANA UNIVERSITY CREDIT UNION | Bloomington | — | $74.8M | 17 |
| LITTLE COMPANY OF MARY HOSPITAL | Jasper | E220 Health Care | $74.6M | 0 |
| STRADA COLLABORATIVE INC | Indianapolis | — | $74.4M | 17 |
| BHI SENIOR LIVING INC | Indianapolis | P75 Human Services | $74.2M | 9 |
| James Whitcomb Riley Memorial Association | Indianapolis | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $73.8M | 8 |
| Johnson County Rural Electric Membership Corporation | Franklin | — | $73.4M | 15 |
| Earlham College | Richmond | B420 Education | $73.2M | 16 |
| UNIVERSITY OF SAINT FRANCIS OF FORT WAYNE INDIANA INC | Fort Wayne | B420 Education | $72M | 13 |
| CLARK COUNTY REMC | Sellersburg | — | $71.6M | 16 |
| UNIVERSITY PEDIATRIC ASSOCIATES INC | Indianapolis | G110 Diseases, Disorders & Medical Disciplines | $71M | 0 |
| PROJECT LEAD THE WAY INC | Indianapolis | B90 Education | $69.7M | 11 |
| HARRISON COUNTY RURAL ELECTRIC | Corydon | — | $69.6M | 15 |
| United Methodist Memorial Home | Warren | P750 Human Services | $69.5M | 8 |
| UNION ASSOCIATED PHYSICIANS CLINIC LLC | Terre Haute | — | $69.1M | 13 |
| PARKVIEW WABASH HOSPITAL INC | Wabash | E20 Health Care | $68.7M | 20 |
| Grace Schools | Winona Lake | B58Z Education | $68.6M | 7 |
| HERITAGE GROUP EMPLOYEE BENEFIT TRUST | Indianapolis | — | $68.2M | 0 |
| Central Indiana Community Foundation Inc | Indianapolis | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $67.8M | 8 |
| SHEET METAL WORKERS LOCAL UNION NO 20 | Indianapolis | J40Z Employment | $67.4M | 9 |
| INDIANA UNIVERSITY | Indianapolis | E300 Health Care | $66.9M | 1 |
| CROSSROADS YMCA INC | Crown Point | P27Z Human Services | $66.9M | 6 |
| Young Men's Christian Association of Greater Indianapolis | Indianapolis | P270 Human Services | $66.2M | 8 |
| UNITED BROTHERHOOD OF CARPENTERS & JOINE | Greenwood | — | $65.9M | 15 |
| ESKENAZI MEDICAL GROUP INC | Indianapolis | E32Z Health Care | $64.9M | 13 |
| SAINT JOSEPH REGIONAL MEDICAL | Plymouth | E220 Health Care | $64.3M | 14 |
| NORTHSHORE HEALTH CENTERS INC | Portage | E30Z Health Care | $64.1M | 9 |
| MANCHESTER UNIVERSITY INC | North Manchester | B420 Education | $63.4M | 14 |
| The American Legion | Indianapolis | — | $62.6M | 14 |
| BEACON CREDIT UNION | Wabash | W61 Public & Societal Benefit | $62.3M | 14 |
